Cord Herbert Brakebusch

Cord Herbert Brakebusch

ORCID: 0000-0002-9342-1634

Publication year:
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51 - 100 out of 203Page size: 50
  1. 2017
  2. Published

    A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis

    Dütting, S., Gaits-Iacovoni, F., Stegner, D., Popp, M., Antkowiak, A., Van Eeuwijk, J. M. M., Nurden, P., Stritt, S., Heib, T., Aurbach, K., Angay, O., Cherpokova, D., Heinz, N., Baig, A. A., Gorelashvili, M. G., Gerner, F., Heinze, K. G., Ware, J., Krohne, G., Ruggeri, Z. M. & 6 others, Nurden, A. T., Schulze, H., Modlich, U., Pleines, I., Brakebusch, Cord Herbert & Nieswandt, B., 15 Jun 2017, In: Nature Communications. 8, 13 p., 15838.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    FMNL formins boost lamellipodial force generation

    Kage, F., Winterhoff, M., Dimchev, V., Mueller, J., Thalheim, T., Freise, A., Brühmann, S., Kollasser, J., Block, J., Dimchev, G. A., Geyer, M., Schnittler, H., Brakebusch, Cord Herbert, Stradal, T. E. B., Carlier, M., Sixt, M., Käs, J., Faix, J. & Rottner, K., 22 Mar 2017, In: Nature Communications. 8, 16 p., 14832.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin

    Woodham, E. F., Paul, N. R., Tyrrell, B., Spence, H. J., Swaminathan, K., Scribner, M. R., Giampazolias, E., Hedley, A., Clark, W., Kage, F., Marston, D. J., Hahn, K. M., Tait, S. W. G., Larue, L., Brakebusch, Cord Herbert, Insall, R. H. & Machesky, L. M., 6 Mar 2017, In: Current biology : CB. 27, 5, p. 624-637 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

    Wahlestedt, M., Erlandsson, E., Kristiansen, T., Lu, R., Brakebusch, Cord Herbert, Weissman, I. L., Yuan, J., Martin Gonzalez, Javier & Bryder, D., 22 Feb 2017, In: Nature Communications. 8, 8 p., 14533.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Cytoskeletal stability in the auditory organ in vivo: RhoA is dispensable for wound healing but essential for hair cell development

    Anttonen, T., Belevich, I., Laos, M., Herranen, A., Jokitalo, E., Brakebusch, Cord Herbert & Pirvola, U., 2017, In: eNeuro. 4, 5, 17 p., e0149-17.2017.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2016
  8. Published

    Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency

    Martin Gonzalez, Javier, Morgani, S. M., Bone, Robert Alexander, Bonderup, K., Abelechian, Sahar, Brakebusch, Cord Herbert & Brickman, Joshua Mark, 9 Aug 2016, In: Stem Cell Reports. 7, 2, p. 177-91 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Changes in dermal matrix in the absence of Rac1 in keratinocytes

    Stanley, A., Pedersen, E. D. K., Brakebusch, Cord Herbert & Quondamatteo, F., May 2016, In: Journal of Anatomy. 228, 5, p. 826-37 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice

    Choudhari, R., Minero, V. G., Menotti, M., Pulito, R., Brakebusch, Cord Herbert, Compagno, M., Voena, C., Ambrogio, C. & Chiarle, R., 10 Mar 2016, In: Blood. 127, 10, p. 1297-306 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation

    López-Posadas, R., Becker, C., Günther, C., Tenzer, S., Amann, K., Billmeier, U., Atreya, R., Fiorino, G., Vetrano, S., Danese, S., Ekici, A. B., Wirtz, S., Thonn, V., Watson, A. J. M., Brakebusch, Cord Herbert, Bergö, M., Neurath, M. F. & Atreya, I., Feb 2016, In: The Journal of Clinical Investigation. 126, 2, p. 611-26 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2015
  13. Published

    Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development

    Elias, B. C., Das, A., Parekh, D. V., Mernaugh, G., Adams, R., Yang, Z., Brakebusch, Cord Herbert, Pozzi, A., Marciano, D. K., Carroll, T. J. & Zent, R., 1 Dec 2015, In: Journal of Cell Science. 128, 23, p. 4293-305 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells

    Schulz, A. M., Stutte, S., Hogl, S., Luckashenak, N., Dudziak, D., Leroy, C., Forné, I., Imhof, A., Müller, S. A., Brakebusch, Cord Herbert, Lichtenthaler, S. F. & Brocker, T., 9 Nov 2015, In: Journal of Cell Biology. 211, 3, p. 553-67 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA

    Li, S., Dislich, B., Brakebusch, Cord Herbert, Lichtenthaler, S. F. & Brocker, T., 1 Nov 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 9, p. 4244-56 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion

    Liu, L., Li, J., Zhang, L., Zhang, F., Zhang, R., Chen, X., Brakebusch, Cord Herbert, Wang, Z. & Liu, X., 27 Oct 2015, In: BioFactors (Oxford, England). 41, 5, p. 352-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets

    Dütting, S., Heidenreich, J., Cherpokova, D., Amin, E., Zhang, S., Ahmadian, M. R., Brakebusch, Cord Herbert & Nieswandt, B., May 2015, In: Journal of Thrombosis and Haemostasis. 13, 5, p. 827-38 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair

    Xia, J., Swiercz, J. M., Bañón-Rodríguez, I., Matković, I., Federico, G., Sun, T., Franz, T., Brakebusch, Cord Herbert, Kumanogoh, A., Friedel, R. H., Martín-Belmonte, F., Gröne, H., Offermanns, S. & Worzfeld, T., May 2015, In: Developmental Cell. 33, 3, p. 299-313 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

    Meehan, T. F., Chen, C. K., Koscielny, G., Relac, M., Wilkinson, P., Flicek, P., Parkinson, H., Bottomley, J., Ramirez-Solis, R., Smedley, D., Castro, A., Fessele, S., Steinkamp, R., Hagn, M., Raess, M., De Angelis, M. H., Ball, S., Blake, A., Fray, M., Kenyon, J. & 23 others, Mallon, A. M., Brown, S., Massimi, M., Matteoni, R., Tocchini-Valentini, G., Herault, Y., Kollias, G., Ulfhake, B., Demengeot, J., Fremond, C., Bosch, F., Montoliu, L., Soininen, R., Schughart, K., Brakebusch, Cord Herbert, Sedlacek, R., Rülicke, T., McKerlie, C., Malissen, B., Iraqi, F., Jonkers, J., Russig, H. & Huylebroeck, D., 28 Jan 2015, In: Nucleic Acids Research. 43, D1, p. D1171-D1175

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity

    Burbage, M., Keppler, S. J., Gasparrini, F., Martínez-Martín, N., Gaya, M., Feest, C., Domart, M., Brakebusch, Cord Herbert, Collinson, L., Bruckbauer, A. & Batista, F. D., 2015, In: The Journal of Experimental Medicine. 212, 1, p. 53-72

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. 2014
  22. Published

    Mouse macrophages completely lacking Rho (RhoA, RhoB and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and increased motility

    Koenigs, V., Jennings, R., Vogl, T., Horsthemke, M., Bachg, A. C., Xu, Y., Grobe, K., Brakebusch, Cord Herbert, Schwab, A., Baehler, M., Knaus, U. G. & Hanley, P. J., 31 Oct 2014, In: The Journal of Biological Chemistry. 289, 44, p. 30772-30784 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    How to Bury the Dead: Elimination of Apoptotic Hair Cells from the Hearing Organ of the Mouse

    Anttonen, T., Belevich, I., Kirjavainen, A., Laos, M., Brakebusch, Cord Herbert, Jokitalo, E. & Pirvola, U., 30 Jul 2014, In: J A R O. 15, 6, p. 975-992 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Rac1-dependent recruitment of PAK2 to G 2 phase centrosomes and their roles in the regulation of mitotic entry

    May, M., Schelle, I., Brakebusch, Cord Herbert, Rottner, K. & Genth, H., 19 May 2014, In: Cell Cycle. 13, 14, p. 2211-21 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    NADPH oxidase complex-derived reactive oxygen species, the actin cytoskeleton, and rho GTPases in cell migration

    Stanley, A., Thompson, K., Hynes, A., Brakebusch, Cord Herbert & Quondamatteo, F., 1 May 2014, In: Antioxidants & Redox Signaling. 20, 13, p. 2026-42 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness

    Jennings, R. T., Strengert, M., Hayes, P., El-Benna, J., Brakebusch, Cord Herbert, Kubica, M. & Knaus, U. G., 29 Apr 2014, In: Blood. 123, 23, p. 3635-45 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The small GTPase Rac1 is required for smooth muscle contraction

    Rahman, A., Davis, B., Lövdahl, C., Hanumaiah, V. T., Feil, R., Brakebusch, Cord Herbert & Arner, A., 1 Mar 2014, In: The Journal of Physiology. 592, 5, p. 915-26 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Rho GTPases and cancer

    Li, H., Peyrollier, K., Kilic, G. & Brakebusch, Cord Herbert, Mar 2014, In: BioFactors (Oxford, England). 40, 2, p. 226-35 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  29. 2013
  30. Published

    Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes

    Wang, Z., Jiang, Z., Zhang, Q., Hu, M., Huang, L., Ou, X., Guo, L., Ouyang, Y., Hou, Y., Brakebusch, Cord Herbert, Schatten, H. & Sun, Q., Dec 2013, In: Molecular Biology of the Cell. 24, 24, p. 3832-41 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

    Pleines, I., Dütting, S., Cherpokova, D., Eckly, A., Meyer, I., Morowski, M., Krohne, G., Schulze, H., Gachet, C., Debili, N., Brakebusch, Cord Herbert & Nieswandt, B., 31 Oct 2013, In: Blood. 122, 18, p. 3178-87 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

    Steffen, A., Ladwein, M., Dimchev, G. A., Hein, A., Schwenkmezger, L., Arens, S., Ladwein, K. I., Margit Holleboom, J., Schur, F., Victor Small, J., Schwarz, J., Gerhard, R., Faix, J., Stradal, T. E. B., Brakebusch, Cord Herbert & Rottner, K., 15 Oct 2013, In: Journal of Cell Science. 126, Pt 20, p. 4572-88 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1

    Huelsenbeck, S. C., Roggenkamp, D., May, M., Huelsenbeck, J., Brakebusch, Cord Herbert, Rottner, K., Ladwein, M., Just, I., Fritz, G., Schmidt, G. & Genth, H., Aug 2013, In: International Journal of Biochemistry & Cell Biology. 45, 8, p. 1767-75 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Neuronal Rac1 is required for learning-evoked neurogenesis

    Haditsch, U., Anderson, M. P., Freewoman, J., Cord, B., Babu, H., Brakebusch, Cord Herbert & Palmer, T. D., 24 Jul 2013, In: Journal of Neuroscience. 33, 30, p. 12229-41 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Cdc42 promotes host defenses against fatal infection

    Lee, K., Boyd, K. L., Parekh, D. V., Kehl-Fie, T. E., Baldwin, H. S., Brakebusch, Cord Herbert, Skaar, E. P., Boothby, M. & Zent, R., 20 May 2013, In: Infection and Immunity. 81, 8, p. 2714-2723 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury

    Blattner, S. M., Hodgin, J. B., Nishio, M., Wylie, S. A., Saha, J., Soofi, A. A., Vining, C., Randolph, A., Herbach, N., Wanke, R., Atkins, K. B., Gyung Kang, H., Henger, A., Brakebusch, Cord Herbert, Holzman, L. B. & Kretzler, M., 15 May 2013, In: Kidney International.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    p21-activated Kinase1(PAK1) can promote ERK activation in a kinase independent manner

    Wang, Z., Fu, M., Wang, L., Liu, J., Li, Y., Brakebusch, Cord Herbert & Mei, Q., 7 May 2013, In: Journal of Biological Chemistry.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis

    Vadodaria, K. C., Brakebusch, Cord Herbert, Suter, U. & Jessberger, S., 16 Jan 2013, In: Journal of Neuroscience. 33, 3, p. 1179-89 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo

    Luckashenak, N., Wähe, A., Breit, K., Brakebusch, Cord Herbert & Brocker, T., 1 Jan 2013, In: Journal of Immunology. 190, 1, p. 27-35 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. 2012
  41. Published

    RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1

    Pedersen, E. D. K., Wang, Z., Stanley, A., Peyrollier, K., Rösner, L. M., Werfel, T., Quondamatteo, F. & Brakebusch, Cord Herbert, 15 Nov 2012, In: Journal of Cell Science. 125, Pt 22, p. 5379-90 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Rho GTPases and Nox dependent ROS production in skin. Is there a connection?

    Stanley, A., Hynes, A., Brakebusch, Cord Herbert & Quondamatteo, F., Nov 2012, In: Histology and Histopathology. 27, 11, p. 1395-406 12 p.

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Opposing roles for RhoH GTPase during T-cell migration and activation

    Baker, C. M., Comrie, W. A., Hyun, Y., Chung, H., Fedorchuk, C. A., Lim, K., Brakebusch, Cord Herbert, McGrath, J. L., Waugh, R. E., Meier-Schellersheim, M. & Kim, M., 26 Jun 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. 10474-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    FMNL2 drives actin-based protrusion and migration downstream of Cdc42

    Block, J., Breitsprecher, D., Kühn, S., Winterhoff, M., Kage, F., Geffers, R., Duwe, P., Rohn, J. L., Baum, B., Brakebusch, Cord Herbert, Geyer, M., Stradal, T. E. B., Faix, J. & Rottner, K., 5 Jun 2012, In: Current Biology. 22, 11, p. 1005-12 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Rho GTPase function in development: How in vivo models change our view

    Pedersen, E. & Brakebusch, Cord Herbert, 29 May 2012, In: Experimental Cell Research. 318, 14, p. 1779-87 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Podocyte-specific loss of cdc42 leads to congenital nephropathy

    Scott, R. P., Hawley, S. P., Ruston, J., Du, J., Brakebusch, Cord Herbert, Jones, N. & Pawson, T., 19 Apr 2012, In: Journal of the American Society of Nephrology. 23, 7, p. 1149-54 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    A radial glia-specific role of RhoA in double cortex formation

    Cappello, S., Böhringer, C. R. J., Bergami, M., Conzelmann, K., Ghanem, A., Tomassy, G. S., Arlotta, P., Mainardi, M., Allegra, M., Caleo, M., van Hengel, J., Brakebusch, Cord Herbert & Götz, M., 8 Mar 2012, In: Neuron. 73, 5, p. 911-24 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

    Sakamori, R., Das, S., Yu, S., Feng, S., Stypulkowski, E., Guan, Y., Douard, V., Tang, W., Ferraris, R. P., Harada, A., Brakebusch, Cord Herbert, Guo, W. & Gao, N., 1 Mar 2012, In: Journal of Clinical Investigation. 122, 3, p. 1052-65 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    A function for Rac1 in the terminal differentiation and pigmentation of hair

    Behrendt, K., Klatte, J., Pofahl, R., Bloch, W., Smyth, N., Tscharntke, M., Krieg, T., Paus, R., Niessen, C., Niemann, C., Brakebusch, Cord Herbert & Haase, I., 24 Jan 2012, In: Journal of Cell Science. 125, Pt 4, p. 896-905 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood

    Anttonen, T., Kirjavainen, A., Belevich, I., Laos, M., Richardson, W. D., Jokitalo, E., Brakebusch, Cord Herbert & Pirvola, U., 2012, In: Scientific Reports. 2, p. 978

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues

    Wagner, S. A., Beli, P., Weinert, B. T., Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Brakebusch, Cord Herbert & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. 2011
  53. Published

    Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

    Pleines, I., Hagedorn, I., Gupta, S., May, F., Chakarova, L., van Hengel, J., Offermanns, S., Krohne, G., Kleinschnitz, C., Brakebusch, Cord Herbert & Nieswandt, B., 1 Nov 2011, In: Blood. 119, 4, p. 1054-63 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo

    Robel, S., Bardehle, S., Lepier, A., Brakebusch, Cord Herbert & Götz, M., 31 Aug 2011, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 31, 35, p. 12471-82 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Cdc42 Controls Vascular Network Assembly Through Protein Kinase C{iota} During Embryonic Vasculogenesis

    Qi, Y., Liu, J., Wu, X., Brakebusch, Cord Herbert, Leitges, M., Han, Y., Corbett, S. A., Lowry, S. F., Graham, A. M. & Li, S., 1 Aug 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 8, p. 1861-70 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool

    Herzog, D., Loetscher, P., van Hengel, J., Knüsel, S., Brakebusch, Cord Herbert, Taylor, V., Suter, U. & Relvas, J. B., 30 Mar 2011, In: Journal of Neuroscience. 31, 13, p. 5120-30 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes

    Jackson, B., Peyrollier, K., Pedersen, E., Basse, A., Karlsson, R., Wang, Z., Lefever, T., Ochsenbein, A. M., Schmidt, G., Aktories, K., Stanley, A., Quondamatteo, F., Ladwein, M., Rottner, K., van Hengel, J. & Brakebusch, Cord Herbert, 1 Mar 2011, In: Molecular Biology of the Cell. 22, 5, p. 593-605 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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