Brice Emanuelli

Brice Emanuelli

Associate Professor


  1. 2000
  2. SOCS-3 is an insulin-induced negative regulator of insulin signaling

    Emanuelli, Brice, Peraldi, P., Filloux, C., Sawka-Verhelle, D., Hilton, D. & Van Obberghen, E., 26 May 2000, In: Journal of Biological Chemistry. 275, 21, p. 15985-15991 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2001
  4. Insulin Induces Suppressor of Cytokine Signaling-3 Tyrosine Phosphorylation through Janus-activated Kinase

    Peraldi, P., Filloux, C., Emanuelli, Brice, Hilton, D. J. & Van Obberghen, E., 6 Jul 2001, In: Journal of Biological Chemistry. 276, 27, p. 24614-24620 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Surfing the insulin signaling web

    Van Obberghen, E., Baron, V., Delahaye, L., Emanuelli, Brice, Filippa, N., Giorgetti-Peraldi, S., Lebrun, P., Mothe-Satney, I., Peraldi, P., Rocchi, S., Sawka-Verhelle, D., Tartare-Deckert, S. & Giudicelli, J., 1 Dec 2001, In: European Journal of Clinical Investigation. 31, 11, p. 966-977 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  6. SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice

    Emanuelli, Brice, Peraldi, P., Filloux, C., Chavey, C., Freidinger, K., Hilton, D. J., Hotamisligil, G. S. & Van Obberghen, E., 21 Dec 2001, In: Journal of Biological Chemistry. 276, 51, p. 47944-47949 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2004
  8. Published

    The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells

    Emanuelli, Brice, Glondu, M., Filloux, C., Peraldi, P. & Van Obberghen, E., Dec 2004, In: Diabetes. 53 Suppl 3, p. S97-S103

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2006
  10. Published

    Critical nodes in signalling pathways: insights into insulin action

    Taniguchi, C. M., Emanuelli, Brice & Kahn, C. R., Feb 2006, In: Nature Reviews. Molecular Cell Biology. 7, 2, p. 85-96 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2008
  12. Published

    Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance

    Emanuelli, Brice, Eberlé, D., Suzuki, R. & Kahn, C. R., 4 Mar 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3545-50 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    SOCS-1 deficiency does not prevent diet-induced insulin resistance

    Emanuelli, Brice, Macotela, Y., Boucher, J. & Ronald Kahn, C., 12 Dec 2008, In: Biochemical and Biophysical Research Communications. 377, 2, p. 447-52 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2010
  15. Published

    Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis

    Zhang, H., Schulz, T. J., Espinoza, D. O., Huang, T. L., Emanuelli, Brice, Kristiansen, Karsten & Tseng, Y., 1 Sep 2010, In: Molecular and Cellular Biology. 30, 17, p. 4224-33 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2011
  17. Published

    Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism

    Macotela, Y., Emanuelli, Brice, Bång, A. M., Espinoza, D. O., Boucher, J., Beebe, K., Gall, W. & Kahn, C. R., 2011, In: PLOS ONE. 6, 6, p. e21187

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

    Bezy, O., Tran, T. T., Pihlajamäki, J., Suzuki, R., Emanuelli, Brice, Winnay, J., Mori, M. A., Haas, J., Biddinger, S. B., Leitges, M., Goldfine, A. B., Patti, M. E., King, G. L. & Kahn, C. R., Jun 2011, In: The Journal of Clinical Investigation. 121, 6, p. 2504-17 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

    Jing, E., Emanuelli, Brice, Hirschey, M. D., Boucher, J., Lee, K. Y., Lombard, D., Verdin, E. M. & Kahn, C. R., 30 Aug 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. 14608-13 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Insulin resistance in the metabolic syndrome

    Biddinger, S. B. & Emanuelli, Brice, 1 Dec 2011, Metabolic Basis of Obesity. Springer New York LLC, p. 175-198 24 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  21. 2012
  22. Published

    Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5)

    Palsgaard, J., Emanuelli, Brice, Winnay, J. N., Sumara, G., Karsenty, G. & Kahn, C. R., 6 Apr 2012, In: The Journal of Biological Chemistry. 287, 15, p. 12016-26 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Intrinsic differences in adipocyte precursor cells from different white fat depots

    Macotela, Y., Emanuelli, Brice, Mori, M. A., Gesta, S., Schulz, T. J., Tseng, Y. & Kahn, C. R., Jul 2012, In: Diabetes. 61, 7, p. 1691-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

    Vernochet, C., Mourier, A., Bezy, O., Macotela, Y., Boucher, J., Rardin, M. J., An, D., Lee, K. Y., Ilkayeva, O. R., Zingaretti, C. M., Emanuelli, Brice, Smyth, G., Cinti, S., Newgard, C. B., Gibson, B. W., Larsson, N. & Kahn, C. R., 5 Dec 2012, In: Cell Metabolism. 16, 6, p. 765-76 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2014
  26. Published

    Interplay between FGF21 and insulin action in the liver regulates metabolism

    Emanuelli, Brice, Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, Mani, Michael, M. D., Adams, A. C., Kharitonenkov, A. & Kahn, C. R., 3 Feb 2014, In: The Journal of Clinical Investigation. 124, 2, p. 515-27 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2015
  28. Published

    Interplay between FGF21 and insulin action in the liver regulates metabolism

    Emanuelli, Brice, Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, Mani, Michael, M. D., Adams, A. C., Kharitonenkov, A. & Kahn, C. R., Jan 2015, In: The Journal of Clinical Investigation. 125, 1, p. 458

    Research output: Contribution to journalComment/debateResearchpeer-review

  29. 2016
  30. Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5)

    Palsgaard, J., Emanuelli, Brice, Winnay, J. N., Sumara, G., Karsenty, G. & Kahn, C. R., 5 Aug 2016, In: The Journal of Biological Chemistry. 291, 32, p. 16878

    Research output: Contribution to journalComment/debateResearchpeer-review

  31. 2017
  32. Published

    Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

    Lundh, M., Plucinska, Kaja, Isidor, Marie Sophie, Petersen, P. S. S. & Emanuelli, Brice, Oct 2017, In: Molecular Metabolism. 6, 10, p. 1313-1320 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2018
  34. Published

    Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

    Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S. & 24 others, Wang, J., Stohlmann, K., Brandslund, I., Christensen, C., Jørgensen, M. E., Linneberg, Allan René, Pedersen, Oluf Borbye, Kiebish, M. A., Qvortrup, Klaus, Han, X., Pedersen, Bente Klarlund, Jastroch, M., Mandrup, S., Kjær, Andreas, Gygi, S. P., Hansen, Torben, Gillum, M. P., Grarup, Niels, Emanuelli, Brice, Nielsen, S., Schéele, Camilla Charlotte Nielsen, Tseng, Y., Færgeman, N. J. & Gerhart-Hines, Zach, 2018, In: Cell Metabolism. 28, 1, p. 159-174.e11

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action

    Rabiee, A., Krüger, M., Ardenkjær-Larsen, J., Ronald Kahn, C. & Emanuelli, Brice, 2018, In: Cellular Signalling. 47, p. 1-15

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. 2019
  37. Published

    Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue

    Lundh, M., Petersen, P. S., Isidor, Marie Sophie, Kazoka-Sørensen, D. N., Plucinska, Kaja, Shamsi, F., Ørskov, Cathrine, Tozzi, M., Brown, E. L., Andersen, E., Ma, Tao, Müller, U. A., Barrès, Romain, Kristiansen, V. B., Gerhart-Hines, Zach, Tseng, Y. & Emanuelli, Brice, 2019, In: EMBO Reports. 20, 8, e48216.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Identification of two microRNA nodes as potential cooperative modulators of liver metabolism

    Hochreuter, Mette Yde, Altıntaş, Ali, Garde, C., Emanuelli, Brice, Kahn, C. R., Zierath, Juleen R, Vienberg, S. & Barrès, Romain, 2019, In: Hepatology Research. 49, 12, p. 1451-1465

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The brominated flame retardant PBDE 99 promotes adipogenesis via regulating mitotic clonal expansion and PPARγ expression

    Wen, Q., Xie, X., Zhao, C., Ren, Q., Zhang, X., Wei, D., Emanuelli, Brice & Du, Y., 2019, In: The Science of the Total Environment. 670, p. 67-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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