Mani Arumugam
Dr. Manimozhiyan Arumugam leads the Microbiome Systems Biology research group, investigating how health and diseases are influenced by our gut microbiome; how the gut microbiome interacts with the host and environmental factors; and how we can therapeutically modulate the gut microbiome to improve health. His research is interdisciplinary, combining metagenomics (a technique to study gut microbiome) and other host-microbial multi-omics readouts to study host-microbial cross-talk. He is the principal investigator in several externally funded studies investigating the role of gut microbiome in multiple sclerosis (Lundbeck Foundation), obesity (Novo Nordisk Foundation), liver diseases (EU Horizon 2020), ageing (Danish Independent Research Council) and producing antimicrobial peptides (Danish Independent Research Council).
Dr. Arumugam received his PhD in computational biology from the European Molecular Biology Laboratory (Heidelberg) in 2010.
Masters Thesis Opportunities in Bioinformatics
Highly motivated Masters students are invited to perform their thesis or project work in our group. We prefer students with experience in programming and/or high performance computing. Background in biology is not necessary! Please check out this flyer!
We are always looking for excellent researchers to join our group
1. | Postdoctoral fellows in bioinformatics or microbiome research: | |
Postdoctoral opportunities are available for outstanding candidates with experience and background in bioinformatics and human gut microbiome. If you like our research and are interested in joining our group, please send me an email. | ||
2. | PhD fellows in bioinformatics or microbiome research: | |
We are always looking for highly motivated PhD students to join us. If you like our research and are interested in joining our group, please send me an email. International students can also apply to the Copenhagen Bioscience PhD Program where I am a participating supervisor. |
Primary fields of research
Human Microbiome, Systems Biology, Bioinformatics, Metagenomics
Current research
Lifestyle changes and lack of physical activity are important factors involved in metabolic disorders. However, emerging evidence suggests that our gut microbiome and their interactions with us play an important role in our health and well-being. An imbalance in the gut microbiome may signify an unhealthy state of the host and contribute to obesity and diabetes pathogenesis.
The Arumugam Group aims to study the interactions between the host and the gut microbiome in order to understand the molecular mechanisms underlying metabolic disorders. The Group takes interdisciplinary approaches combining multi-omics microbiome data to study host-microbial cross-talk. The Group also investigates therapeutic approaches to modulate the gut microbiome towards improving human health.
Fields of interest
Systems Biology, Human Diseases, Genomics, Machine Learning
Selected publications
- Published
Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India
Alvarez Silva, Maria Camila, Kashani, A., Hansen, T. H., Pinna, N. K., Anjana, R. M., Dutta, A., Saxena, S., Støy, J., Kampmann, U., Nielsen, T., Jørgensen, T., Gnanaprakash, V., Gnanavadivel, R., Sukumaran, A., Rani, C. S. S., Færch, K., Radha, V., Balasubramanyam, M., Nair, G. B., Das, B., drb459, drb459, Hansen, Torben, Mande, S. S., Mohan, V., Arumugam, Mani & Pedersen, Oluf Borbye, 2021, In: Genome Medicine. 13, 37.Research output: Contribution to journal › Journal article › peer-review
- Published
Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure
Trebicka, J., Bork, P., Krag, A. & Arumugam, Mani, 2021, In: Nature Reviews Gastroenterology & Hepatology. 18, p. 167-180 14 p.Research output: Contribution to journal › Review › peer-review
- Published
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
Wirbel, J., Pyl, P. T., Kartal, E., Zych, K., Kashani, A., Milanese, A., Fleck, J. S., Voigt, A. Y., Palleja, A., Ponnudurai, R., Sunagawa, S., Coelho, L. P., Schrotz-King, P., Vogtmann, E., Habermann, N., Niméus, E., Thomas, A. M., Manghi, P., Gandini, S., Serrano, D., Mizutani, S., Shiroma, H., Shiba, S., Shibata, T., Yachida, S., Yamada, T., Waldron, L., Naccarati, A., Segata, N., Sinha, R., Ulrich, C. M., Brenner, H., Arumugam, Mani, Bork, P. & Zeller, G., 2019, In: Nature Medicine. 25, 4, p. 679-689 11 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Circulating microbiome in blood of different circulatory compartments
Schierwagen, R., Alvarez Silva, Maria Camila, Madsen, M. S. A., Kolbe, C. C., Meyer, C., Thomas, D., Uschner, F. E., Magdaleno, F., Jansen, C., Pohlmann, A., Praktiknjo, M., Hischebeth, G. T., Molitor, E., Latz, E., Lelouvier, B., Trebicka, J. & Arumugam, Mani, 2019, In: Gut. 68, 3, p. 578-580Research output: Contribution to journal › Letter › peer-review
- Published
Recovery of gut microbiota of healthy adults following antibiotic exposure
Palleja, A., Mikkelsen, K. H., Forslund, S. K., Kashani, A., Allin, K. H., Nielsen, T., Hansen, T. H., Liang, S., Feng, Q., Zhang, C., Pyl, P. T., Coelho, L. P., Yang, H., Wang, J., Typas, A., Nielsen, M. F., Nielsen, H. B., Bork, P., Wang, J., Vilsbøll, Tina, Hansen, Torben, Knop, Filip Krag, Arumugam, Mani & Pedersen, Oluf Borbye, Nov 2018, In: Nature Microbiology. 3, 11, p. 1255-1265 11 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
Yu, J., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, Jan, Li, Y., Wang, X., Xu, X., Chen, N., Wu, W. K. K., Al-Aama, J., Nielsen, H. J., Kiilerich, P., Jensen, Benjamin Anderschou Holbech, Yau, T. O., Lan, Z., Jia, H., Li, J., Xiao, L., Lam, T. Y. T., Ng, S. C., Cheng, A. S., Wong, V. W., Chan, F. K. L., Xu, X., Yang, H., Madsen, L., Datz, C., Tilg, H., Wang, J., Brünner, N., Kristiansen, Karsten, Arumugam, Mani, Sung, J. J. & Wang, J., 2017, In: Gut. 66, p. 70-78 9 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota
Palleja, A., Kashani, A., Allin, K. H., Nielsen, T., Zhang, C., Li, Y., Brach, Thorsten, Liang, S., Feng, Q., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Burgdorf, Kristoffer Sølvsten, Holst, Jens Juul, Madsbad, Sten, Wang, J., Pedersen, Oluf Borbye, Hansen, Torben & Arumugam, Mani, 2016, In: Genome Medicine. 8, 13 p., 67.Research output: Contribution to journal › Journal article › peer-review
- Published
A catalog of the mouse gut metagenome
Xiao, L., Feng, Q., Liang, S., Sonne, Si Brask, Xia, Z., Qiu, X., Li, X., Long, H., Zhang, J., Zhang, D., Liu, C., Fang, Z., Chou, J., Glanville, J., Hao, Q., Kotowska, D. E., S.Colding-Christensen, Camilla, Licht, T. R., Wu, D., Yu, J., Sung, J. J. Y., Liang, Q., Li, J., Jia, H., Lan, Z., Tremaroli, V., Dworzynski, P., Nielsen, H. B., Bäckhed, G. F., Dore, J., Le Chatelier, E., Ehrlich, S. D., Lin, J. C., Arumugam, Mani, Wang, J., Madsen, L. & Kristiansen, Karsten, 2015, In: Nature Biotechnology. 33, 10, p. 1103-1108 6 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Genomic variation landscape of the human gut microbiome
Schloissnig, S., Arumugam, Mani, Sunagawa, S., Mitreva, M., Tap, J., Zhu, A., Waller, A., Mende, D. R., Kultima, J. R., Martin, J., Kota, K., Sunyaev, S. R., Weinstock, G. M. & Bork, P., 2013, In: Nature. 493, 7430, p. 45-50 6 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum
Arumugam, Mani, Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., Batto, J., dos Santos, M. B. Q., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, Torben, Hattori, M., Hayashi, T., Kleerebezem, M., Kurokawa, K., Leclerc, M., Levenez, F., Manichanh, C., Nielsen, H. B., Nielsen, T., Pons, N., Poulain, J., Qin, J., Sicheritz-Ponten, T., Tims, S., Torrents, D., Ugarte, E., Zoetendal, E. G., Wang, J., Guarner, F., Pedersen, Oluf Borbye, de Vos, W. M., Brunak, Søren, Doré, J., Antolín, M., Artiguenave, F., Blottiere, H. M., Almeida, M., Brechot, C., Cara, C., Chervaux, C., Cultrone, A., Delorme, C., Denariaz, G., Kristiansen, Karsten & MetaHIT Consortium, M. C., 2011, In: Nature. 473, 7346, p. 174-180 7 p.Research output: Contribution to journal › Journal article › peer-review
- Published
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, M. C., 2010, In: Nature. 464, 7285, p. 59-65 6 p.Research output: Contribution to journal › Journal article › peer-review
Selected activities
Pharmabiotics Conference 2018
Arumugam, Mani (Invited speaker)
15 Mar 2018Activity: Participating in an event - types › Organisation of and participation in conference
Gut Microbiota for Health World Summit 2018
Arumugam, Mani (Invited speaker)
10 Mar 2018Activity: Participating in an event - types › Organisation of and participation in conference
25th United European Gastroenterology Week
Arumugam, Mani (Invited speaker)
30 Oct 2017Activity: Participating in an event - types › Organisation of and participation in conference
25th United European Gastroenterology Week
Arumugam, Mani (Organizer)
30 Oct 2017Activity: Participating in an event - types › Organisation of and participation in conference
53rd Congress of the European Societies of Toxicology
Arumugam, Mani (Invited speaker)
11 Sep 2017Activity: Participating in an event - types › Organisation of and participation in conference
12th Copenhagen Bioscience Conference
Arumugam, Mani (Organizer)
1 Oct 2017 → 5 Oct 2017Activity: Participating in an event - types › Organisation of and participation in conference
European Microbiome Congress
Arumugam, Mani (Invited speaker)
1 Dec 2016Activity: Participating in an event - types › Participation in workshop, seminar, course
Wenner-Gren Foundation Symposium
Arumugam, Mani (Invited speaker)
16 Jun 2016Activity: Participating in an event - types › Participation in workshop, seminar, course
EMBL Conference: The Human Microbiome
Arumugam, Mani (Organizer)
10 Jun 2015 → 12 Jun 2015Activity: Participating in an event - types › Organisation of and participation in conference
Seminar: Human Microbiome
Arumugam, Mani (Lecturer)
14 Aug 2014 → 19 Aug 2014Activity: Talk or presentation types › Lecture and oral contribution
ID: 41056735
Most downloads
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1187
downloads
A human gut microbial gene catalogue established by metagenomic sequencing
Research output: Contribution to journal › Journal article › peer-review
Published -
587
downloads
Circulating microbiome in blood of different circulatory compartments
Research output: Contribution to journal › Letter › peer-review
Published -
415
downloads
An Improved Method for High Quality Metagenomics DNA Extraction from Human and Environmental Samples
Research output: Contribution to journal › Journal article › peer-review
Published