Mani Arumugam

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Dr. Manimozhiyan Arumugam leads the Microbiome Systems Biology research group, investigating how health and diseases are influenced by our gut microbiome; how the gut microbiome interacts with the host and environmental factors; and how we can therapeutically modulate the gut microbiome to improve health. His research is interdisciplinary, combining metagenomics (a technique to study gut microbiome) and other host-microbial multi-omics readouts to study host-microbial cross-talk. He is the principal investigator in several externally funded studies investigating the role of gut microbiome in multiple sclerosis (Lundbeck Foundation), obesity (Novo Nordisk Foundation), liver diseases (EU Horizon 2020), ageing (Danish Independent Research Council) and producing antimicrobial peptides (Danish Independent Research Council).

Dr. Arumugam received his PhD in computational biology from the European Molecular Biology Laboratory (Heidelberg) in 2010.

Masters Thesis Opportunities in Bioinformatics

Highly motivated Masters students are invited to perform their thesis or project work in our group. We prefer students with experience in programming and/or high performance computing. Background in biology is not necessary! Please check out this flyer!

We are always looking for excellent researchers to join our group

Primary fields of research

Human Microbiome, Systems Biology, Bioinformatics, Metagenomics, Machine Learning, Artificial Intelligence

Current research

Lifestyle changes and lack of physical activity are important factors involved in metabolic disorders. However, emerging evidence suggests that our gut microbiome and their interactions with us play an important role in our health and well-being. An imbalance in the gut microbiome may signify an unhealthy state of the host and contribute to obesity and diabetes pathogenesis.

The Arumugam Group aims to study the interactions between the host and the gut microbiome in order to understand the molecular mechanisms underlying metabolic disorders. The Group takes interdisciplinary approaches combining multi-omics microbiome data to study host-microbial cross-talk. The Group also investigates therapeutic approaches to modulate the gut microbiome towards improving human health.

Fields of interest

Systems Biology, Human Diseases, Genomics, Machine Learning

Selected publications

1. Published

   Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India

   Alvarez-Silva, C., Kashani, A., Hansen, T. H., Pinna, N. K., Anjana, R. M., Dutta, A., Saxena, S., Støy, J., Kampmann, U., Nielsen, T., Jørgensen, T., Gnanaprakash, V., Gnanavadivel, R., Sukumaran, A., Rani, C. S. S., Færch, K., Radha, V., Balasubramanyam, M., Nair, G. B., Das, B. & 6 others, drb459, drb459, Hansen, Torben, Mande, S. S., Mohan, V., Arumugam, Mani & Pedersen, Oluf Borbye, 2021, In: Genome Medicine. 13, 37.

   Research output: Contribution to journal › Journal article › Research › peer-review

2. Published

   Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure

   Trebicka, J., Bork, P., Krag, A. & Arumugam, Mani, 2021, In: Nature Reviews Gastroenterology & Hepatology. 18, p. 167-180 14 p.

   Research output: Contribution to journal › Review › Research › peer-review

3. Published

   Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

   Wirbel, J., Pyl, P. T., Kartal, E., Zych, K., Kashani, A., Milanese, A., Fleck, J. S., Voigt, A. Y., Palleja, A., Ponnudurai, R., Sunagawa, S., Coelho, L. P., Schrotz-King, P., Vogtmann, E., Habermann, N., Niméus, E., Thomas, A. M., Manghi, P., Gandini, S., Serrano, D. & 15 others, Mizutani, S., Shiroma, H., Shiba, S., Shibata, T., Yachida, S., Yamada, T., Waldron, L., Naccarati, A., Segata, N., Sinha, R., Ulrich, C. M., Brenner, H., Arumugam, Mani, Bork, P. & Zeller, G., 2019, In: Nature Medicine. 25, 4, p. 679-689 11 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

4. Published

   Circulating microbiome in blood of different circulatory compartments

   Schierwagen, R., Alvarez Silva, Maria Camila, Madsen, M. S. A., Kolbe, C. C., Meyer, C., Thomas, D., Uschner, F. E., Magdaleno, F., Jansen, C., Pohlmann, A., Praktiknjo, M., Hischebeth, G. T., Molitor, E., Latz, E., Lelouvier, B., Trebicka, J. & Arumugam, Mani, 2019, In: Gut. 68, 3, p. 578-580

   Research output: Contribution to journal › Letter › Research › peer-review

5. Published

   Recovery of gut microbiota of healthy adults following antibiotic exposure

   Palleja, A., Mikkelsen, K. H., Forslund, S. K., Kashani, A., Allin, K. H., Nielsen, T., Hansen, T. H., Liang, S., Feng, Q., Zhang, C., Pyl, P. T., Coelho, L. P., Yang, H., Wang, J., Typas, A., Nielsen, M. F., Nielsen, H. B., Bork, P., Wang, J., Vilsbøll, T. & 4 others, Hansen, Torben, Knop, Filip Krag, Arumugam, Mani & Pedersen, Oluf Borbye, Nov 2018, In: Nature Microbiology. 3, 11, p. 1255-1265 11 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   Genomic variation landscape of the human gut microbiome

   Schloissnig, S., Arumugam, Mani, Sunagawa, S., Mitreva, M., Tap, J., Zhu, A., Waller, A., Mende, D. R., Kultima, J. R., Martin, J., Kota, K., Sunyaev, S. R., Weinstock, G. M. & Bork, P., 2013, In: Nature. 493, 7430, p. 45-50 6 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

7. Published

   Enterotypes of the human gut microbiome: [Plus]Corrigendum [Plus]Addendum

   Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., Batto, J-M., dos Santos, M. B. Q., Borruel, N., Casellas, F., Fernandez, L., Gautier, L., Hansen, T., Hattori, M., Hayashi, T., Kleerebezem, M., Kurokawa, K. & 31 others, Leclerc, M., Levenez, F., Manichanh, C., Nielsen, H. B., Nielsen, T., Pons, N., Poulain, J., Qin, J., Sicheritz-Ponten, T., Tims, S., Torrents, D., Ugarte, E., Zoetendal, E. G., Wang, J., Guarner, F., Pedersen, Oluf Borbye, de Vos, W. M., Brunak, Søren, Doré, J., Antolín, M., Artiguenave, F., Blottiere, H. M., Almeida, M., Brechot, C., Cara, C., Chervaux, C., Cultrone, A., Delorme, C., Denariaz, G., Kristiansen, Karsten & MetaHIT Consortium, M. C., 2011, In: Nature. 473, 7346, p. 174-180 7 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

8. Published

   A human gut microbial gene catalogue established by metagenomic sequencing

   MetaHIT Consortium, M. C., 2010, In: Nature. 464, 7285, p. 59-65 6 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

Selected activities

1. EMBO|EMBL Symposium: The Human Microbiome

   Arumugam, Mani (Organizer)

   20 Sep 2023 → 23 Sep 2023

   Activity: Participating in an event - types › Organisation of and participation in conference

2. EMBO|EMBL Symposium: The Human Microbiome

   Arumugam, Mani (Organizer)

   16 Sep 2018 → 19 Sep 2018

   Activity: Participating in an event - types › Organisation of and participation in conference

3. Pharmabiotics Conference 2018

   Arumugam, Mani (Invited speaker)

   15 Mar 2018

   Activity: Participating in an event - types › Organisation of and participation in conference

4. Gut Microbiota for Health World Summit 2018

   Arumugam, Mani (Invited speaker)

   10 Mar 2018

   Activity: Participating in an event - types › Organisation of and participation in conference

5. 25th United European Gastroenterology Week

   Arumugam, Mani (Invited speaker)

   30 Oct 2017

   Activity: Participating in an event - types › Organisation of and participation in conference

6. EMBL Conference: The Human Microbiome

   Arumugam, Mani (Organizer)

   10 Jun 2015 → 12 Jun 2015

   Activity: Participating in an event - types › Organisation of and participation in conference

7. Seminar: Human Microbiome

   Arumugam, Mani (Lecturer)

   14 Aug 2014 → 19 Aug 2014

   Activity: Talk or presentation types › Lecture and oral contribution