Bo Torben Porse

Bo Torben Porse

Professor, Clinical Professor

Member of:

  • Internal Medicine: Haematology

ORCID: 0000-0001-6043-0844

Publication year:
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1 - 50 out of 125Page size: 50
  1. 1995
  2. Published

    Mapping important nucleotides in the peptidyl transferase centre of 23 S rRNA using a random mutagenesis approach.

    Porse, Bo Torben & Garrett, R. A., 1995, In: Journal of Molecular Biology. 249, 1, p. 1-10 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 1996
  4. Published

    A sparsomycin-resistant mutant of Halobacterium salinarium lacks a modification at nucleotide U2603 in the peptidyl transferase centre of 23 S rRNA

    Lázaro, E., Rodriguez-Fonseca, C., Porse, Bo Torben, Ureña, D., Garrett, Roger Antony & Ballesta, J. P. G., 16 Aug 1996, In: Journal of Molecular Biology. 261, 2, p. 231-238 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Antibiotic inhibition of the movement of tRNA substrates through a peptidyl transferase cavity.

    Porse, Bo Torben, Rodriguez-Fonseca, C., Leviev, I. & Garrett, R. A., 1996, In: Biochemistry and Cell Biology. 73, 11-12, p. 877-85 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The donor substrate site within the peptidyl transferase loop of 23 S rRNA and its putative interactions with the CCA-end of N-blocked aminoacyl-tRNA(Phe).

    Porse, Bo Torben, Thi-Ngoc, H. P. & Garrett, R. A., 1996, In: Journal of Molecular Biology. 264, 3, p. 472-83 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 1997
  8. Published

    Movement of the 3'-end of tRNA through the peptidyl transferase centre and its inhibition by antibiotics

    Kirillov, S., Porse, Bo Torben, Vester, B., Woolley, P. & Garrett, Roger Antony, 1997, In: FEBS Letters. 406, 3, p. 223-233 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 1998
  10. Published

    The antibiotic thiostrepton inhibits a functional transition within protein L11 at the ribosomal GTPase centre

    Porse, Bo Torben, Leviev, I., Mankin, A. S. & Garrett, R. A., 1998, In: Journal of Molecular Biology. 276, 2, p. 391-404 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Assembly of proteins and 5S rRNA to transcripts of the major structural domains of 23S rRNA

    Østergaard, P., Phan, H., Johansen, L. B., Egebjerg, J., Østergaard, L., Porse, Bo Torben & Garrett, Roger Antony, 1 Nov 1998, In: Journal of Molecular Biology. 284, 2, p. 227-240 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 1999
  13. Published

    Peptidyl transferase antibiotics perturb the relative positioning of the 3'-terminal adenosine of P/P'-site-bound tRNA and 23S rRNA in the ribosome

    Kirillov, S. V., Porse, Bo Torben & Garrett, R. A., 1999, In: RNA: A publication of the RNA Society. 5, 8, p. 1003-13 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes.

    Porse, Bo Torben, Kirillov, S. V., Awayez, M. J., Ottenheijm, H. C. & Garrett, R. A., 1999, In: Proceedings of the National Academy of Science of the United States of America. 96, 16, p. 9003-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Ribosomal mechanics, antibiotics, and GTP hydrolysis.

    Porse, Bo Torben & Garrett, R. A., 1999, In: Cell. 97, 4, p. 423-6 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms.

    Porse, Bo Torben & Garrett, R. A., 1999, In: Journal of Molecular Biology. 286, 2, p. 375-87 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The antibiotic micrococcin acts on protein L11 at the ribosomal GTPase centre.

    Porse, Bo Torben, Cundliffe, E. & Garrett, Roger Antony, 1999, In: Journal of Molecular Biology. 287, 1, p. 33-45 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    UV-induced modifications in the peptidyl transferase loop of 23S rRNA dependent on binding of the streptogramin B antibiotic, pristinamycin IA.

    Porse, Bo Torben, Kirillov, S. V., Awayez, M. J. & Garrett, R. A., 1999, In: RNA: A publication of the RNA Society. 5, 4, p. 585-95 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their binding mechanisms

    Porse, Bo Torben & Garrett, Roger Antony, 1999, In: Journal of Molecular Biology. 286, p. 375-387

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. 2000
  21. Published

    Puromycin-rRNA interaction sites at the peptidyl transferase center

    Rodriguez-Fonseca, C., Phan, H., Long, K. S., Porse, Bo Torben, Kirilov, S. V., Amils, R. & Garrett, Roger Antony, 2000, In: RNA: A publication of the RNA Society. 6, 5, p. 744-754 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 2001
  23. Published

    E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.

    Porse, Bo Torben, Pedersen TA, Xu, X., Lindberg, B., Wewer, Ulla M., Friis-Hansen, L. & Nerlov, C., 2001, In: Cell. 107, 2, p. 247-58 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2003
  25. Published

    A conserved chloramphenicol binding site at the entrance to the ribosomal peptide exit tunnel.

    Long, K. S. & Porse, Bo Torben, 2003, In: Nucleic Acids Research. 31, 24, p. 7208-15 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Transgene mus som sygdomsmodeller.

    Schuster, Mikkel Bruhn & Porse, Bo Torben, 2003, In: Ugeskrift for læger. 165, 8, p. 793-6 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. 2004
  28. Published

    A novel partial modification at C2501 in Escherichia coli 23S ribosomal RNA

    Andersen, T., Porse, Bo Torben & Kirpekar, F., 1 Jun 2004, In: RNA. 10, 6, p. 907-913 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. 2005
  30. Published

    Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.

    Porse, Bo Torben, Bryder, D., Theilgaard-Mønch, Kim, Hasemann, M. S., Anderson, K., Damgaard, I., Jacobsen, S. E. W. & Nerlov, C., 2005, In: Journal of Experimental Medicine. 202, 1, p. 85-96 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils.

    Theilgaard-Mønch, Kim, Jacobsen, L. C., Rasmussen, T., Niemann, C. U., Udby, L., Borup, R., Gharib, M., Arkwright, P. D., Gombart, A. F., Calafat, J., Porse, Bo Torben & Borregaard, N., 2005, In: Journal of Leukocyte Biology. 78, 2, p. 462-70 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Systems biology of neutrophil differentiation and immune response.

    Theilgaard-Mønch, Kim, Porse, Bo Torben & Borregaard, N., 2005, In: Current Opinion in Immunology. 18, 1, p. 54-60 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Messenger RNA surveillance: neutralizing natural nonsense.

    Weischenfeldt, Joachim Lütken, Lykke-Andersen, J. & Porse, Bo Torben, 2005, In: Current Biology. 15, 14, p. R559-62

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. 2006
  35. Published

    Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

    Kirstetter, P., Anderson, K., Porse, Bo Torben, Jacobsen, S. E. W. & Nerlov, C., 2006, In: Nature Immunology. 7, 10, p. 1048-56 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo.

    Porse, Bo Torben, Pedersen, T. A., Hasemann, M. S., Schuster, Mikkel Bruhn, Kirstetter, P., Luedde, T., Damgaard, I., Kurz, E., Schjerling, C. K. & Nerlov, C., 2006, In: Molecular and Cellular Biology. 26, 3, p. 1028-37 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    C/EBPalpha: a tumour suppressor in multiple tissues?

    Schuster, Mikkel Bruhn & Porse, Bo Torben, 2006, In: BBA General Subjects. 1766, 1, p. 88-103 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation.

    Theilgaard-Mønch, Kim, Jacobsen, L. C., Nielsen, M. J., Rasmussen, T., Udby, L., Gharib, M., Arkwright, P. D., Gombart, A. F., Calafat, J., Moestrup, S. K., Porse, Bo Torben & Borregaard, N., 2006, In: Blood. 108, 1, p. 353-61 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. 2007
  40. Published

    The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.

    Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mønch, Kim, Minucci, S., Porse, Bo Torben, Marine, J., Hansen, K. H. & Helin, K., 2007, In: Genes & Development. 21, 5, p. 525-30 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.

    Pedersen, T. A., Bereshchenko, O., Garcia-Silva, S., Ermakova, O., Kurz, E., Mandrup, S., Porse, Bo Torben & Nerlov, C., 2007, In: EMBO Journal. 26, 4, p. 1081-93 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. 2008
  43. Published

    Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice

    Christoffersen, C., Jauhiainen, M., Moser, M., Porse, Bo Torben, Ehnholm, C., Boesl, M., Dahlback, B. & Nielsen, L. B., 2008, In: Journal of Biological Chemistry. 283, 4, p. 1839-1847 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice

    Christoffersen, Christina, Jauhiainen, M., Moser, M., Porse, Bo Torben, Ehnholm, C., Boesl, M., Dahlbäck, B. & Nielsen, L. B., 25 Jan 2008, In: The Journal of Biological Chemistry. 283, 4, p. 1839-47 9 p.

    Research output: Contribution to journal › Journal article › Research

  45. Published

    Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.

    Hasemann, M. S., Damgaard, I., Schuster, Mikkel Bruhn, Theilgaard-Mønch, Kim, Sørensen, A. B., Mrsic, A., Krugers, T., Ylstra, B., Pedersen, F. S., Nerlov, C. & Porse, Bo Torben, 2008, In: Blood. 111, 8, p. 4309-21 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

    Kirstetter, P., Schuster, Mikkel Bruhn, Bereshchenko, O., Moore, S., Dvinge, H., Kurz, E., Theilgaard-Mønch, Kim, Månsson, R., Pedersen, T. A., Pabst, T., Schrock, E., Porse, Bo Torben, Jacobsen, S. E. W., Bertone, P., Tenen, D. G. & Nerlov, C., 2008, In: Cancer Cell. 13, 4, p. 299-310 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Bone Marrow-derived Macrophages (BMMs): Isolation and applications.

    Weischenfeldt, Joachim Lütken & Porse, Bo Torben, 2008, In: Cold Spring Harbor Protocols.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.

    Weischenfeldt, Joachim Lütken, Damgaard, I., Bryder, D., Theilgaard-Mønch, Kim, Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C. & Porse, Bo Torben, 2008, In: Genes & Development. 22, 10, p. 1381-96 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. 2009
  50. Published

    Leukemia - methods and protocols

    Porse, Bo Torben, 2009, In: European Journal of Haematology. 84, 1, p. 94

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    C/EBPalpha in leukemogenesis: Identity and origin of the leukemia-initiating cell

    Schuster, Mikkel Bruhn & Porse, Bo Torben, 2009, In: BioFactors. 35, 3, p. 227-31 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. 2010
  53. Published

    A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia

    Marstrand, T. T., Borup, R., Willer, A., Borregaard, N., Sandelin, Albin Gustav, Porse, Bo Torben & Theilgaard-Mønch, Kim, Jul 2010, In: Leukemia. 24, 7, p. 1265-75 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

    Pasini, D., Malatesta, M., Jung, H. R., Valfridsson, J. O. A., Willer, A., Olsson, L., Skotte, J., Wutz, A., Porse, Bo Torben, Jensen, O. N. & Helin, K., Aug 2010, In: Nucleic Acids Research. 38, 15, p. 4958-69 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Basal stamcellebiologi og cancer

    Porse, Bo Torben, Petersen, Ole William & Helin, K., 20 Sep 2010, In: Ugeskrift for læger. 172, 38, p. 2600-3 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    UPF2 is a critical regulator of liver development, function and regeneration

    Thoren, L. A., Nørgaard, G. A., Weischenfeldt, Joachim Lütken, Waage, J., Jakobsen, J. S., Damgaard, I., Bergström, F. C., Blom, A. M., Borup, R., Bisgaard, Hanne Cathrine & Porse, Bo Torben, 2010, In: PLoS ONE. 5, 7, p. e11650

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Lipocalin 2 is protective against E. coli pneumonia

    Wu, H., Santoni-Rugiu, E., Ralfkiaer, E., Porse, Bo Torben, Moser, Claus Ernst, Høiby, Niels, Borregaard, N. & Cowland, J. B., 2010, In: Respiratory research. 11, p. 96

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Lipocalin 2 is protective against E. coli pneumonia

    Wu, H., Santoni Rugiu, Eric, Ralfkiaer, E., Porse, Bo Torben, Moser, C., Høiby, Niels, Borregaard, N., Cowland, J. B., Wu, H., Santoni Rugiu, Eric, Ralfkiær, E., Porse, B. T., Moser, C. E., Høiby, N., Borregaard, N. & Cowland, J., 15 Jun 2010, In: Respiratory research (Online). 11, 96, 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. 2011
  60. Published

    Immunophenotypical characterization of human neutrophil differentiation

    Jensen, H. M., Jendholm, J., Fossum, A., Porse, Bo Torben, Borregaad, N. & Theilgaard-Mønch, Kim, 7 Jun 2011, In: Journal of Leukocyte Biology. p. 629-634 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Technical advance: immunophenotypical characterization of human neutrophil differentiation

    Mora-Jensen, H. I., Jendholm, J., Fossum, A., Porse, Bo Torben, Borregaard, N. & Theilgaard-Mönch, K., 2011, In: Journal of Leukocyte Biology. 90, 3, p. 629-34 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Gene expression profiling in MDS and AML: potential and future avenues

    Theilgaard-Mönch, K., Boultwood, J., Ferrari, S., Giannopoulos, K., Hernandez-Rivas, J. M., Kohlmann, A., Morgan, M., Porse, B., Tagliafico, E., Zwaan, C. M., Wainscoat, J., Van den Heuvel-Eibrink, M. M., Mills, K., Bullinger, L., Theilgaard-Mönch, K., Boultwood, J., Ferrari, S., Giannopoulos, K., Hernandez-Rivas, J. M., Kohlmann, A. & 8 others, Morgan, M., Porse, Bo Torben, Tagliafico, E., Zwaan, C. M., Wainscoat, J., Van den Heuvel-Eibrink, M. M., Mills, K. & Bullinger, L., 2011, In: Leukemia. 25, 6, p. 909-20 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. 2012
  64. Published

    BLUEPRINT to decode the epigenetic signature written in blood

    Adams, D., Altucci, L., Antonarakis, S. E., Ballesteros, J., Beck, S., Bird, A., Bock, C., Boehm, B., Campo, E., Caricasole, A., Dahl, F., Dermitzakis, E. T., Enver, T., Esteller, M., Estivill, X., Ferguson-Smith, A., Fitzgibbon, J., Flicek, P., Giehl, C., Graf, T. & 37 others, Grosveld, F., Guigo, R., Gut, I., Helin, K., Jarvius, J., Küppers, R., Lehrach, H., Lengauer, T., Lernmark, Å., Leslie, D., Loeffler, M., Macintyre, E., Mai, A., Martens, J. H. A., Minucci, S., Ouwehand, W. H., Pelicci, P. G., Pendeville, H., Porse, Bo Torben, Rakyan, V., Reik, W., Schrappe, M., Schübeler, D., Seifert, M., Siebert, R., Simmons, D., Soranzo, N., Spicuglia, S., Stratton, M., Stunnenberg, H. G., Tanay, A., Torrents, D., Valencia, A., Vellenga, E., Vingron, M., Walter, J. & Willcocks, S., 2012, In: Nature Biotechnology. 30, 3, p. 224-6 3 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  65. Published

    HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis

    Bagger, F. O., Rapin, N. P. J., Theilgaard-Mønch, Kim, Kaczkowski, B., Jendholm, L. J., Winther, O. & Porse, Bo Torben, 2012, In: Blood. 119, 26, p. 6394-6395 2 p.

    Research output: Contribution to journal › Comment/debate › Research

  66. Published

    Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency

    Hasemann, M. S., Schuster, Mikkel Bruhn, Frank, Anne-Katrine, Theilgaard-Mønch, Kim, Pedersen, T. Å., Nerlov, C. & Porse, Bo Torben, 2012, In: P L o S One. 7, 6, p. e38841

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML

    Treppendahl, M. B., Qiu, X., Søgaard, A., Yang, X., Nandrup-Bus, C., Hother, C., Andersen, M. K., Kjeldsen, L., Möllgård, L., Möllgaard, L., Hellström-Lindberg, E., Jendholm, L. J., Porse, Bo Torben, Jones, P. A., Liang, G. & Grønbæk, Kirsten, 5 Jan 2012, In: Blood. 119, 1, p. 206-16 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 4985646