Messenger RNA surveillance: neutralizing natural nonsense.
Research output: Contribution to journal › Journal article › Research › peer-review
Messenger RNA transcripts that contain premature stop codons are degraded by a process termed nonsense-mediated mRNA decay (NMD). Although previously thought of as a pathway that rids the cell of non-functional mRNAs arising from mutations and processing errors, new research suggests a more general and evolutionarily important role for NMD in the control of gene expression.
Original language | English |
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Journal | Current Biology |
Volume | 15 |
Issue number | 14 |
Pages (from-to) | R559-62 |
ISSN | 0960-9822 |
DOIs | |
Publication status | Published - 2005 |
Bibliographical note
Keywords: Animals; Caenorhabditis elegans; Codon, Nonsense; Gene Expression Regulation; Mice; Models, Biological; Pseudogenes; RNA Helicases; RNA Stability; RNA, Small Nucleolar
ID: 5142139