Birgitte Holst

Birgitte Holst

Guest Researcher


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  1. Published

    Ligand binding and micro-switches in 7TM receptor structures

    Nygaard, R., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Schwartz, Thue W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway

    Ratner, C., He, Z., Grunddal, Kaare Villum, Skov, Louise Julie, Hartmann, Bolette, Zhang, F., Feuchtinger, A., Bjerregaard, Anette, Christoffersen, Christina, Tschöp, M. H., Finan, B., DiMarchi, R. D., Leinninger, G. M., Williams, K. W., Clemmensen, Christoffer & Holst, Birgitte, 2019, In: Diabetes. 68, 6, p. 1329-1340

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation

    Bellmann-Sickert, K., Elling, C. E., Madsen, A. N., Little, P. B., Lundgren, K., Gerlach, L., Bergmann, R., Holst, Birgitte, Schwartz, Thue W. & Beck-Sickinger, A. G., 2011, In: Journal of Medicinal Chemistry. 54, 8, p. 2658-67 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans

    Andersson, E. A., Holst, Birgitte, Sparsø, T., Grarup, Niels, Banasik, Karina, Holmkvist, J., Jørgensen, T., Borch-Johnsen, K., Egerod, Kristoffer Lihme, Lauritzen, T., Sørensen, Thorkild I.A., Bonnefond, A., Meyre, D., Froguel, P., Schwartz, Thue W., Pedersen, Oluf Borbye & Hansen, Torben, 2010, In: Diabetes. 59, 6, p. 1539-48 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Melanocortin 4 receptor mutations in obese Czech children: Studies of prevalence, phenotype development, weight reduction response, and functional analysis

    Hainerova, I., Larsen, L. H., Holst, Birgitte, Finkova, M., Hainer, V., Lebl, J., Hansen, T. & Pedersen, O., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 9, p. 3689-3696 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Metabolic insights from a GHSR-A203E mutant mouse model

    Pedersen, Lola Julie Torz, Osborne-Lawrence, S., Rodriguez, J., He, Z., Paula Cornejo, M., Roman Mustafa, E., Jin, C., Petersen, N., Hedegaard, M. A., Nybo, Maja Lind, Martinez Damonte, V., Metzger, N. P., Mani, B. K., Williams, K. W., Raingo, J., Perello, M., Holst, Birgitte & Zigman, J. M., 2020, In: Molecular Metabolism. 39, 16 p., 101004.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation

    Elling, C. E., Frimurer, T. M., Gerlach, L., Jorgensen, R., Holst, Birgitte & Schwartz, Thue W., 2006, In: Journal of Biological Chemistry. 281, 25, p. 17337-46 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

    Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Biological Chemistry. 277, 49, p. 47662-70 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.

    Frimurer, Thomas Michael, Mende, F., Graae, A., Engelstoft, M. S., Egerod, Kristoffer Lihme, Nygaard, R., Gerlach, L., Hansen, J. B., Schwartz, Thue W. & Holst, Birgitte, 2017, In: Journal of Medicinal Chemistry. 60, 3, p. 886-898 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Modifying the conserved C-terminal tyrosine of the peptide hormone PYY3-36 to improve Y2 receptor selectivity

    Pedersen, S. L., Holst, Birgitte, Vrang, N. & Jensen, Knud Jørgen, 2009, In: Journal of Peptide Science. 15, 11, p. 753-759 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

    Mokrosinski, J., Frimurer, Thomas Michael, Sivertsen, B., Schwartz, Thue W. & Holst, Birgitte, Sep 2012, In: Journal of Biological Chemistry. 287, p. 33488-33502 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Modulation of the constitutive activity of the ghrelin receptor by use of pharmacological tools and mutagenesis

    Mokrosinski, J. & Holst, Birgitte, Jan 2010, In: Methods in Enzymology. 484, p. 53-73 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII

    Gbahou, F., Holst, Birgitte & Schwartz, Thue W., 2010, In: Journal of Pharmacology and Experimental Therapeutics. 333, 1, p. 51-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Molecular mechanism of 7TM receptor activation--a global toggle switch model

    Schwartz, Thue W., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39

    Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: FEBS Letters. 582, 17, p. 2583-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe

    Holst, Birgitte & Schwartz, Thue W., 2003, In: Annals of the New York Academy of Sciences. 994, p. 1-11 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Molecular structure and function of 7TM/G-protein coupled receptors

    Schwartz, Thue W. & Holst, Birgitte, 2002, Textbook of receptor Pharmacology. p. 65-84

    Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

  18. Published

    NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype

    Martini, L., Hastrup, H., Holst, Birgitte, Fraile-Ramos, A., Marsh, M. & Schwartz, Thue W., 2002, In: Molecular Pharmacology. 62, 1, p. 30-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

    Rosenkilde, Mette, Lucibello, M., Holst, Birgitte & Schwartz, Thue W., 1998, In: FEBS Letters. 439, 1-2, p. 35-40 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Neprilysin activity is increased in metabolic dysfunction-associated steatotic liver disease and normalizes after bariatric surgery or GLP-1 therapy

    Kjeldsen, S. A. S., Gluud, L. L., Werge, M. P., Pedersen, J. S., Bendtsen, F., Alexiadou, K., Tan, T., Torekov, S. S., Iepsen, E. W., Jensen, N. J., Richter, M. M., Goetze, J. P., Rungby, J., Hartmann, B., Holst, J. J., Holst, B., Holt, J., Gustafsson, F., Madsbad, S., Svane, M. S. & 2 others, Bojsen-Møller, K. N. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: iScience. 26, 11, 13 p., 108190.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Neuromedin U inhibits food intake partly by inhibiting gastric emptying

    Dalbøge, L. S., Pedersen, S. L., Secher, T., Holst, Birgitte, Vrang, N. & Jelsing, J., Jul 2015, In: Peptides. 69, p. 56-65 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism

    Grunddal, Kaare Villum, Ratner, C. F., Svendsen, B., Sommer, F., Engelstoft, M. S., Madsen, A. N., Pedersen, Jens, Nøhr, M. K., Egerod, Kristoffer Lihme, Nawrocki, A. R., Kowalski, T., Howard, A. D., Poulsen, Steen Seier, Offermanns, S., Bäckhed, G. F., Holst, Jens Juul, Holst, Birgitte & Schwartz, Thue W., Jan 2016, In: Endocrinology. 157, 1, p. 176-94 19 p., en20151600.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    New potential agents for cryopreservation of hematopoietic and adipose stromal cells

    Svalgaard, J., Haastrup, E., Brink, A., Clausen, C., Holst, Birgitte, Theilgaard-Mønch, Kim, Reckzeh, K. & Fischer-Nielsen, A., Apr 2014, In: Cytotherapy. 16, Supplement 4, p. S58

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  24. Published

    Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

    Holst, Birgitte, Brandt, E., Bach, Anders, Heding, A. & Schwartz, Thue W., 2005, In: Molecular Endocrinology. 19, 9, p. 2400-11 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor

    Holst, Birgitte, Frimurer, T. M., Mokrosinski, J., Halkjaer, T., Cullberg, K. B., Underwood, C. R. & Schwartz, Thue W., 2008, In: Molecular Pharmacology. 75, 1, p. 44-59 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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