Michael J. Davies
Professor
Inflammation, Metabolism and Oxidation
Blegdamsvej 3
2200 København N.
- Published
Structural and functional changes in RNAse A originating from tyrosine and histidine cross-linking and oxidation induced by singlet oxygen and peroxyl radicals
Leinisch, F., Mariotti, M., Hägglund, Per Mårten & Davies, Michael J., Oct 2018, In: Free Radical Biology and Medicine. 126, p. 73-86Research output: Contribution to journal › Journal article › Research › peer-review
The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages
Lane, A. E., Tan, J. T. M., Hawkins, Clare Louise, Heather, A. K. & Davies, Michael J., 15 Aug 2010, In: Biochemical Journal. 430, 1, p. 161-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links
Lund, Marianne N., Luxford, C., Skibsted, Leif Horsfelt & Davies, Michael J., 2008, In: Biochemical Journal. 410, 3, p. 565-574Research output: Contribution to journal › Journal article › Research › peer-review
Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals
Lam, M. A., Pattison, D. I., Bottle, S. E., Keddie, D. J. & Davies, Michael J., Nov 2008, In: Chemical Research in Toxicology. 21, 11, p. 2111-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Key role of cysteine residues and sulfenic acids in thermal- and H2O2-mediated modification of β-lactoglobulin
Krämer, A. C., Thulstrup, Peter Waaben, Lund, Marianne N. & Davies, Michael J., 2016, In: Free Radical Biology & Medicine. 97, 8, p. 544–555 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Key role of cysteine residues in thermal- and H2O2-mediated modification of beta-lactoglobulin
Krämer, A. C., Thulstrup, Peter Waaben, Lund, Marianne N. & Davies, Michael J., 2016, In: Free Radical Biology & Medicine. 96, Suppl. 1, p. S16 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Effect of Methylglyoxal-Induced Glycation on the Composition and Structure of β-Lactoglobulin and α-Lactalbumin
Krämer, A. C. & Davies, Michael J., 2019, In: Journal of Agricultural and Food Chemistry. 67, 2, p. 699-710 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Oxidation and Protein Unfolding on Cross-Linking of β-Lactoglobulin and α-Lactalbumin
Krämer, A. C., Torreggiani, A. & Davies, Michael J., 2017, In: Journal of Agricultural and Food Chemistry. 65, 47, p. 10258-10269 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1
Kovacevic, Z., Sahni, S., Lok, K. H., Davies, Michael J., Wink, D. A. & Richardson, D. R., May 2017, In: B B A - Reviews on Cancer. 1861, 5 Pt A, p. 995-999 5 p.Research output: Contribution to journal › Review › Research › peer-review
Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations
Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., Scott, K. F., Ziegler, J. B., Pattison, D. I., Fu, S., Hawkins, Clare Louise, Rees, M. D. & Davies, Michael J., 15 Apr 2010, In: Biochemical Pharmacology. 79, 8, p. 1156-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative time-courses of copper-ion-mediated protein and lipid oxidation in low-density lipoprotein
Knott, H. M., Baoutina, A., Davies, Michael J. & Dean, R. T., 15 Apr 2002, In: Archives of Biochemistry and Biophysics. 400, 2, p. 223-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes. Formation of modified and oxidized particles
Knott, H. M., Brown, B. E., Davies, Michael J. & Dean, R. T., Sep 2003, In: European Journal of Biochemistry. 270, 17, p. 3572-82 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice
Kim, C. H. J., Mitchell, J. B., Bursill, C. A., Sowers, A. L., Thetford, A., Cook, J. A., van Reyk, D. M. & Davies, Michael J., May 2015, In: Atherosclerosis. 240, 1, p. 234-241 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: Three year follow-up of a cluster randomised controlled trial in primary care
Khunti, K., Gray, L. J., Skinner, Timothy, Carey, M. E., Realf, K., Dallosso, H., Fisher, H., Campbell, M., Heller, S. & Davies, Michael J., 9 Jun 2012, In: BMJ (Online). 344, 7860, e2333.Research output: Contribution to journal › Journal article › Research › peer-review
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Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study
Khunti, K., Taub, N., Tringham, J., Jarvis, J., Farooqi, A., Skinner, Timothy & Davies, Michael J., 1 Apr 2010, In: Primary Care Diabetes. 4, 1, p. 25-32 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biomedical, lifestyle and psychosocial characteristics of people newly diagnosed with type 2 diabetes: Baseline data from the DESMOND randomized controlled trial
Khunti, K., Skinner, Timothy, Heller, S., Carey, M. E., Dallosso, H. M. & Davies, Michael J., 1 Dec 2008, In: Diabetic Medicine. 25, 12, p. 1454-1461 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Special issue for the International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems (EPR-2017)
Khramtsov, V. V. & Davies, Michael J., 2018, In: Free Radical Research. 52, 3, p. 305-306Research output: Contribution to journal › Editorial › Research
Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid
Kennett, E. C. & Davies, Michael J., 1 Sep 2008, In: Free Radical Biology & Medicine. 45, 5, p. 716-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mechanisms and consequences of oxidative damage to extracellular matrix
Kennett, E. C., Chuang, Christine, Degendorfer, G., Whitelock, J. M. & Davies, Michael J., Oct 2011, In: Biochemical Society Transactions. 39, 5, p. 1279-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Degradation of matrix glycosaminoglycans by peroxynitrite/peroxynitrous acid: evidence for a hydroxyl-radical-like mechanism
Kennett, E. C. & Davies, Michael J., 15 Apr 2007, In: Free Radical Biology & Medicine. 42, 8, p. 1278-89 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Glycosaminoglycans are fragmented by hydroxyl, carbonate, and nitrogen dioxide radicals in a site-selective manner: implications for peroxynitrite-mediated damage at sites of inflammation
Kennett, E. C. & Davies, Michael J., 15 Aug 2009, In: Free Radical Biology & Medicine. 47, 4, p. 389-400 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains
Kennett, E. C., Rees, M. D., Malle, E., Hammer, A., Whitelock, J. M. & Davies, Michael J., 15 Jul 2010, In: Free Radical Biology & Medicine. 49, 2, p. 282-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic view of iodide in oxidative stress: [Meeting Abstract]
Kciuk, M. I., Davies, Michael J. & Marciniak, B., 2018, In: Free Radical Biology and Medicine. 120, S1, p. S122-S122 P-254.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Computational design of effective, bioinspired HOCl antioxidants: the role of intramolecular Cl+ and H+ shifts
Karton, A., O'Reilly, R. J., Pattison, D. I., Davies, Michael J. & Radom, L., 21 Nov 2012, In: Journal of the American Chemical Society. 134, 46, p. 19240-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of disulfide (cystine) oxidation by HOCl in a model peptide: Evidence for oxygen addition, disulfide bond cleavage and adduct formation with thiols
Karimi, M., Crossett, B., Cordwell, S. J., Pattison, David & Davies, Michael J., 2020, In: Free Radical Biology and Medicine. 154, p. 62-74 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability
Karimi, M., Ignasiak, M. T., Chan, B., Croft, A. K., Radom, L., Schiesser, C. H., Pattison, D. I. & Davies, Michael J., 12 Dec 2016, In: Scientific Reports. 6, 12 p., 38572.Research output: Contribution to journal › Journal article › Research › peer-review
Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides
Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K., Fu, S., Bottle, S. E., Hawkins, Clare Louise & Davies, Michael J., May 2014, In: Free Radical Biology & Medicine. 70, p. 96-105 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine
Kadiiska, M. B., Basu, S., Brot, N., Cooper, C., Saari Csallany, A., Davies, Michael J., George, M. M., Murray, D. M., Jackson Roberts, L., Shigenaga, M. K., Sohal, R. S., Stocker, R., Van Thiel, D. H., Wiswedel, I., Hatch, G. E. & Mason, R. P., Aug 2013, In: Free Radical Biology & Medicine. 61, p. 408-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peroxynitrous acid-modified extracellular matrix alters gene and protein expression in human coronary artery smooth muscle cells and induces a pro-inflammatory phenotype
Jørgensen, Sara Marthedal, Lorentzen, Lasse Gøbel, Chuang, Christine & Davies, Michael J., 2022, In: Free Radical Biology and Medicine. 186, p. 43-52Research output: Contribution to journal › Journal article › Research › peer-review
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The inflammatory oxidant peroxynitrous acid modulates the structure and function of the recombinant human V3 isoform of the extracellular matrix proteoglycan versican
Jørgensen, Sara Marthedal, Lorentzen, Lasse Gøbel, Hammer, A., Hoefler, G., Malle, E., Chuang, Christine & Davies, Michael J., 2023, In: Redox Biology. 64, 19 p., 102794.Research output: Contribution to journal › Journal article › Research › peer-review
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FIBROSIS IS NOT JUST FIBROSIS - TGF-B AND PDGF INDUCE DIFFERENT EXTRACELLULAR MATRIX PROFILE: A MODEL OF DERMAL FIBROBLASTS WHICH MIMICS SYSTEMIC SCLEROSIS POTENTIAL FOR EVALUATION OF ANTI-FIBROTIC COMPOUNDS WITH TRANSLATIONAL BIOMARKERS [Meeting Abstract}
Juhl, P., Bomdesen, S., Bay-Jensen, A., Karsdal, M., Davies, Michael J. & Siebuhr, A. S., 2019, In: Annals of the Rheumatic Diseases. 78, S2, p. 448-449 THU0335.Research output: Contribution to journal › Conference abstract in journal › Research
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Dermal fibroblasts have different extracellular matrix profiles induced by TGF-beta, PDGF and IL-6 in a model for skin fibrosis
Juhl, P., Bondesen, S., Hawkins, Clare Louise, Karsdal, M. A., Bay-Jensen, A., Davies, Michael J. & Siebuhr, A. S., 2020, In: Scientific Reports. 10, 1, 10 p., 17300.Research output: Contribution to journal › Journal article › Research › peer-review
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Phenotypic changes to vascular smooth muscle cells induced by oxidant-modified extracellular matrix
Jørgensen, Sara Marthedal, Chuang, Christine & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 165, 1 p., NC38.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Phenotypic changes to vascular smooth muscle cells induced by extracellular matrix modification
Jørgensen, Sara Marthedal, Chuang, Christine & Davies, Michael J., 2021, In: Free Radical Biology & Medicine. 165, Suppl. 1, p. 36-37 NC38.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Competitive kinetics as a tool to determine rate constants for reduction of ferrylmyoglobin by food components
Jongberg, S., Lund, Marianne N., Pattison, David, Skibsted, Leif Horsfelt & Davies, Michael J., 2016, In: Food Chemistry. 199, p. 36-41 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Competitive reduction of perferrylmyoglobin radicals by protein thiols and plant phenols
Jongberg, S., Lund, Marianne N., Skibsted, Leif Horsfelt & Davies, Michael J., 2014, In: Journal of Agricultural and Food Chemistry. 62, 46, p. 11279-11288 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated levels of iodide promote peroxidase-mediated protein iodination and inhibit protein chlorination
Jokumsen, Kathrine Væver, Huhle, V. H., Hägglund, Per Mårten, Davies, Michael J. & Gamon, Luke Francis, 2024, In: Free Radical Biology and Medicine. 220, p. 207-221 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxidant-mediated modification and cross-linking of beta-2-microglobulin
Jiang, S., Fuentes Lemus, Eduardo & Davies, Michael J., 2022, In: Free Radical Biology and Medicine. 187, p. 59-71Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crosslinking of human plasma C-reactive protein to human serum albumin via disulfide bond oxidation
Jiang, S., Hägglund, Per Mårten, Carroll, L., Rasmussen, L. M. & Davies, Michael J., 2021, In: Redox Biology. 41, 17 p., 101925.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation of protein cross-links by singlet oxygen-mediated disulfide oxidation
Jiang, S., Carroll, L., Mariotti, M., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Redox Biology. 41, 16 p., 101874.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxidation of protein disulfide bonds by singlet oxygen gives rise to glutathionylated proteins
Jiang, S., Carroll, L., Rasmussen, L. M. & Davies, Michael J., 2021, In: Redox Biology. 38, 16 p., 101822.Research output: Contribution to journal › Journal article › Research › peer-review
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Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?
Ismael, F. O., Barrett, T. J., Sheipouri, D., Brown, B. E., Davies, Michael J. & Hawkins, Clare Louise, 2016, In: P L o S One. 11, 12, 16 p., e0168844.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparative reactivity of the myeloperoxidase-derived oxidants HOCl and HOSCN with low-density lipoprotein (LDL): implications for foam cell formation in atherosclerosis
Ismael, F. O., Proudfoot, J. M., Brown, B. E., van Reyk, D. M., Croft, K. D., Davies, Michael J. & Hawkins, C. L., May 2015, In: Archives of Biochemistry and Biophysics. 573, p. 40-51 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Myoglobin-induced oxidative damage: evidence for radical transfer from oxidized myoglobin to other proteins and antioxidants
Irwin, J. A., Ostdal, H. & Davies, Michael J., 1 Feb 1999, In: Archives of Biochemistry and Biophysics. 362, 1, p. 94-104 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function
Indo, H. P., Hawkins, Clare Louise, Nakanishi, I., Matsumoto, K., Matsui, H., Suenaga, S., Davies, Michael J., St Clair, D. K., Ozawa, T. & Majima, H. J., 2017, Pharmacology of Mitochondria. Springer, Vol. 240. p. 439-456 18 p. (Handbook of Experimental Pharmacology, Vol. 240).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion
Indo, H. P., Matsui, H., Chen, J., Zhu, H., Hawkins, Clare Louise, Davies, Michael J., Yarana, C., Clair, D. K. S. & Majima, H. J., 1 Jul 2015, In: Journal of Clinical Biochemistry and Nutrition. 57, 1, p. 13-20 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space
Indo, H. P., Majima, H. J., Terada, M., Suenaga, S., Tomita, K., Yamada, S., Higashibata, A., Ishioka, N., Kanekura, T., Nonaka, I., Hawkins, Clare Louise, Davies, Michael J., Clair, D. K. S. & Mukai, C., 16 Dec 2016, In: Scientific Reports. 6, 10 p., 39015.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Iodide anions show protective and damaging effects in oxidation of amino acids, peptides and proteins: [Meeting Abstract]
Ignasiak-Kciuk, M., Shashikadze, B., Frackowiak, K., Gamon, Luke Francis, Davies, Michael J. & Marciniak, B., 2019, In: Free Radical Biology and Medicine. 139, S1, p. S30-S30 89.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Unexpected light emission from tyrosyl radicals as a probe for tyrosine oxidation
Ignasiak, M., Frackowiak, K., Pedzinski, T., Davies, Michael J. & Marciniak, B., 2020, In: Free Radical Biology and Medicine. 153, p. 12-16 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypoxia of human endothelial artery wall cells affects arterial extracellular matrix remodelling and contributes to atherosclerosis development
Huang, S., Chuang, Christine & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 563 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
ID: 38036205
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Protein oxidation and peroxidation
Research output: Contribution to journal › Review › Research › peer-review
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Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes
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Cardiac spheroids as promising in vitro models to study the human heart microenvironment
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