Flemming Pociot

Flemming Pociot

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


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  1. Published

    PDE12 in type 1 diabetes

    Tekin, H., Josefsen, K., Krogvold, L., Dahl-Jørgensen, K., Gerling, I., Pociot, Flemming & Buschard, K., 2022, In: Scientific Reports. 12, 18149.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Pannexin-2-deficiency sensitizes pancreatic beta-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo

    Berchtold, L. A., Miani, M., Diep, T. A., Madsen, A. N., Cigliola, V., Colli, M., Miskovic Krivokapic, Jelena, Pociot, Flemming, Eizirik, D. L., Meda, P., Holst, Birgitte, Billestrup, Nils & Storling, J., 2017, In: Molecular and Cellular Endocrinology. 448, p. 108-121 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins

    Kyvsgaard, J. N., Ellervik, Christina, Lindkvist, E. B., Pipper, C. B., Pociot, Flemming, Svensson, Jannet & Thorsen, S. U., 2019, In: Nutrients. 11, 11 p., 1980.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period

    Frørup, C., Mirza, A. H., Yarani, R., Nielsen, L. B., Mathiesen, Elisabeth, Damm, Peter, Svare, J., Engelbrekt, C., Størling, Joachim, Johannesen, Jesper, Mortensen, H. B., Pociot, Flemming & Kaur, S., 2021, In: Frontiers in Immunology. 12, 744509.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Plasma lipid species at type 1 diabetes onset predict residual beta-cell function after 6 months

    Overgaard, A. J., Weir, J. M., Jayawardana, K., Mortensen, H. B., Pociot, Flemming & Meikle, P. J., 2018, In: Metabolomics. 14, 12, 9 p., 158.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy

    Overgaard, A. J., Hansen, H. G., Lajer, M., Pedersen, L., Tarnow, L., Rossing, Peter, McGuire, J. N. & Pociot, Flemming, 2010, In: Proteome Science. 8, p. 4 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Polymorphisms in the CTSH gene may influence the progression of diabetic retinopathy: a candidate-gene study in the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)

    Thorsen, S. U., Sandahl, K., Nielsen, L. B., Broe, R., Rasmussen, M. L., Peto, T., Grauslund, J., Andersen, M. L. M., Mortensen, H. B., Pociot, Flemming, Olsen, B. S. & Brorsson, C., Nov 2015, In: Graefe's Archive for Clinical and Experimental Ophthalmology. 253, 11, p. 1959-65 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Potential beneficial effects of a gluten-free diet in newly diagnosed children with type 1 diabetes: a pilot study

    Svensson, Jannet, Sildorf, S. M., Pipper, C. B., Kyvsgaard, J. N., Bøjstrup, J., Pociot, Flemming, Mortensen, H. B. & Buschard, K., 7 Jul 2016, In: SpringerPlus. 5, 8 p., 994.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Precision diagnostic approach to predict 5-year risk for microvascular complications in type 1 diabetes

    Al-Sari, N., Kutuzova, Svetlana, Suvitaival, T., Henriksen, P., Pociot, Flemming, Rossing, Peter, McCloskey, D. & Legido-Quigley, C., 2022, In: EBioMedicine. 80, 104032.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells

    Kaur, S., Frørup, C., Mirza, A. H., Fløyel, T., Yarani, R., Colli, M. L., Johannesen, Jesper, Størling, Joachim, Eizirik, D. L. & Pociot, Flemming, 2022, In: Non-coding RNA. 8, 5, 19 p., 69.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Reference serum percentile values of adiponectin, leptin, and adiponectin/leptin ratio in healthy Danish children and adolescents

    Hamann, T. V., Mørk, F. C. B., Jensen, Andreas Kryger, Jørgensen, Niklas Rye, Heidemann, M. S., Schou, A. J., Mølgaard, Christian, Pociot, Flemming, Wedderkopp, N. & Johannesen, Jesper, 2022, In: Scandinavian Journal of Clinical and Laboratory Investigation. 82, 4, p. 267-276 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes

    Nielsen, L. B., Vaziri-Sani, F., Pörksen, S., Andersen, Marie Louise Charlotte M, Svensson, J., Bergholdt, R., Pociot, Flemming, Hougaard, P., de Beaufort, C., Castaño, L., Mortensen, H. B., Lernmark, A., Hansen, L. & Hvidoere Study Group On Childhood Diabetes, H. S. G. O. C. D., Dec 2011, In: Autoimmunity Highlights. 44, 8, p. 616-23 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex

    Viken, M. K., Blomhoff, A., Olsson, M., Akselsen, H. E., Pociot, Flemming, Nerup, J., Kockum, I., Cambon-Thomsen, A., Thorsby, E., Undlien, D. E. & Lie, B. A., 2009, In: Genes and Immunity. 10, 4, p. 323-333 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Residual β-cell function and the insulin-like growth factor system in Danish children and adolescents with type 1 diabetes

    Sorensen, J. S., Birkebaek, N. H., Bjerre, M., Pociot, Flemming, Kristensen, K., Hoejberg, A. S., Frystyk, J. & Danish Society for Diabetes in Childhood and Adolescence, D. S. F. D. I. C. A. A., Mar 2015, In: The Journal of Clinical Endocrinology & Metabolism. 100, 3, p. 1053-61 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Results of the MHC fine mapping workshop

    Rich, S. S., Akolkar, B., Concannon, P., Erlich, H., Hilner, J., Julier, C., Morahan, G., Nerup, J., Nierras, C., Pociot, Flemming & Todd, J. A., 2009, In: Diabetes, Obesity and Metabolism. 11, SUPPL. 1, p. 108-109 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Selenium supplementation for patients with Graves’ hyperthyroidism (the GRASS trial): study protocol for a randomized controlled trial

    Watt, Torquil, Cramon, P., Bjorner, J. B., Bonnema, S. J., Feldt-Rasmussen, Ulla, Gluud, C., Gram, J., Hansen, J. L., Hegedüs, L., Knudsen, Nils Jakob, Bach-Mortensen, P., Nolsöe, R., Nygaard, Birte, Pociot, Flemming, Skoog, M., Winkel, P. & Rasmussen, A. K., 2013, In: Trials. 14, April , p. 1-10 10 p., 119.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes

    Brorsson, C. A., Pociot, Flemming & Type 1 Diabetes Genetics Consortium, T. 1. D. G. C., Oct 2015, In: Diabetes Care. 38, Suppl 2, p. S8-S13

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Spatially conserved regulatory elements identified within human and mouse Cd247 gene using high-throughput sequencing data from the ENCODE project.

    Pundhir, Sachin, Hannibal, T. D., Bang-Berthelsen, C. H., Wegener, A. K., Pociot, Flemming, Holmberg, D. I. & Gorodkin, Jan, 2 May 2014, In: Gene. 545, 1, p. 80-87 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

    Karlsen, A. E., Heding, P. E., Frobøse, H., Rønn, S. G., Kruhøffer, M., Orntoft, T. F., Darville, M., Eizirik, D. L., Pociot, Flemming, Nerup, J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 1 Nov 2004, In: Diabetologia. 47, 11, p. 1998-2011 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Survey of 800+ data sets from human tissue and body fluid reveals xenomiRs are likely artifacts

    Kang, W., Bang-Berthelsen, C. H., Holm, A., Houben, A. J. S., Müller, A. H., Thymann, Thomas, Pociot, Flemming, Estivill, X. & Friedländer, M. R., 2017, In: RNA. 23, 4, p. 433-445 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    Systematic evaluation of genes and genetic variants associated with type 1 diabetes susceptibility

    Ram, R., Mehta, M., Nguyen, T. Q., Larma, I., Boehm, B. O., Pociot, Flemming, Concannon, P. & Morahan, G., 2016, In: Journal of Immunology. 196, 7, p. 3043-3053 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Systemic TNF alpha correlates with residual beta-cell function in children and adolescents newly diagnosed with type 1 diabetes

    Overgaard, A. J., Madsen, J. O. B., Pociot, Flemming, Johannesen, Jesper & Størling, Joachim, 2020, In: BMC Pediatrics. 20, 1, 6 p., 446.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Systemic levels of CCL2, CCL3, CCL4 and CXCL8 differ according to age, time period and season among children newly diagnosed with type 1 diabetes and their healthy siblings

    Thorsen, S. U., Eising, S., Mortensen, H. B., Skogstrand, K., Pociot, Flemming, Johannesen, Jesper, Svensson, Jannet & Danish Childhood Diabetes Registry, D. C. D. R., Dec 2014, In: Scandinavian Journal of Immunology. 80, 6, p. 452-461 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The Role of an iNOS Polymorphism at the Post-Diagnosis Diabetes Development in Children with Type 1 Diabetes

    Johannesen, J., Eriksen, V., Andersen, M. L. M., Nielsen, L. B., Svensson, Jannet, Bergholdt, R., Pociot, Flemming & Mortensen, H. B., 2017, In: Journal of Endocrinology and Diabetes Research . 2, 2, 5 p., 100114.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    The Faroese, a genetic isolate with a strong founder effect, allows the identification of Type 1 diabetes susceptibility regions

    Nolsoe, R., Roin, J., Deckert, M., Bergholdt, R., Kelly, J., Brorsson, C., Harley, J., Olsen, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2008, In: Clinical Immunology. 127, Suppl. S, p. S105-S105

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The Rac2 GTPase contributes to cathepsin H-mediated protection against cytokine-induced apoptosis in insulin-secreting cells

    Floyel, T., Mirza, A. H., Kaur, S., Frorup, C., Yarani, R., Størling, Joachim & Pociot, Flemming, 2020, In: Molecular and Cellular Endocrinology. 518, 11 p., 110993.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The effect of saffron supplementation on glycemic parameters: An overview of systematic reviews

    Sadigi, B., Yarani, R., Mirghafourvand, M., Travica, N., Yousefi, Z., Shakouri, S. K., Ostadrahimi, A., Mobasseri, M., Pociot, Flemming, Sanaie, S. & Araj-Khodaei, M., 2022, In: Phytotherapy Research. 36, 9, p. 3444-3458 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    The emerging role of lncrnas in inflammatory bowel disease

    Yarani, R., Mirza, A. H., Kaur, S. & Pociot, Flemming, 2018, In: Experimental and Molecular Medicine. 50, p. 1-14 161.

    Research output: Contribution to journal › Review › Research › peer-review

  29. Published

    The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus

    Kaur, S., Mirza, A. H., Brorsson, C. A., Fløyel, T., Størling, Joachim, Mortensen, H. B., Pociot, Flemming & Hvidoere International Study Group, H. I. S. G., 5 Jan 2016, In: Molecular and Cellular Endocrinology. 419, p. 83-91 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    The identification and functional annotation of RNA structures conserved in vertebrates

    Seemann, Ernst Stefan, Mirza, A. H., Hansen, C., Bang-Berthelsen, C. H., Garde, C., Christensen-Dalsgaard, M., Torarinsson, E., Yao, Z., Workman, C. T., Pociot, Flemming, Nielsen, Henrik, Tommerup, Niels, Ruzzo, W. L. & Gorodkin, Jan, 2017, In: Genome Research. 27, p. 1371-1383 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    The metabolic syndrome is frequent in children and adolescents with type 1 diabetes compared to healthy controls

    Mork, F. B., Madsen, J. O. B., Pilgaard, Kasper Ascanius, Jensen, Andreas Kryger, Klakk, H., Tarp, J., Bugge, A., Heidemann, M., van Hall, Gerrit, Pociot, Flemming, Wedderkopp, N. & Johannesen, Jesper, 2022, In: Pediatric Diabetes. 23, 7, p. 1064-1072 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC

    Engholm-Keller, K., Birck, P., Størling, Joachim, Pociot, Flemming, Mandrup-Poulsen, Thomas & Larsen, M. R., 22 Oct 2012, In: International Journal of Proteomics. 75, 18, p. 5749-61 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets

    Bergholdt, R., Karlsen, A. E., Hagedorn, P. H., Aalund, M., Nielsen, Jens Høiriis, Kruhoffer, M., Orntoft, T., Wang, H., Wollheim, C. B., Nerup, J. & Pociot, Flemming, 2007, In: Genes and Immunity. 8, 3, p. 232-238 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Transcriptome landscape of protein-coding genes and long noncoding RNAs in the colon and blood of DSS-induced mouse model of Acute ulcerative colitis

    Yarani, R., Palasca, Oana, Doncheva, Nadezhda Tsankova, Anthon, Christian, Pilecki, B., Litman, Thomas, Holmskov, U., Jensen, Lars Juhl, Gorodkin, Jan & Pociot, Flemming, 2019, In: Journal of Crohn's and Colitis. 13, p. S129-S130

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  35. Published

    Transcriptomic landscape of lncRNAs in inflammatory bowel disease

    Mirza, A. H., Bang-Berthelsen, C. H., Seemann, Ernst Stefan, Pan, X., Frederiksen, K. S., Vilien, M., Gorodkin, Jan & Pociot, Flemming, 2015, In: Genome Medicine. 7, 22 p., 39.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Tu1766 – Dysregulated Lncrnas in Inflammatory Bowel Disease Demonstrate Immune System Related Association Through Guilt-By Association Analysis

    Yarani, R., Mirza, A. H., Kaur, S. & Pociot, Flemming, 1 May 2019, In: Gastroenterology. 156, 6, p. S-1116 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis

    Størling, J. & Pociot, Flemming, 16 Feb 2017, In: Genes. 8, 2, 12 p., 72.

    Research output: Contribution to journal › Review › Research › peer-review

  38. Published

    Type 1 database mellitus: an inflammatory disease of the islet.

    Bergholdt, R., Heding, P., Nielsen, K., Nolsøe, R., Sparre, T., Størling, J., Nerup, J., Pociot, Flemming & Mandrup-Poulsen, Thomas, 2004, In: Advances in Experimental Medicine and Biology. 552, p. 129-53 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Type 1 diabetes genome-wide association studies: Not to be lost in translation

    Pociot, Flemming, Dec 2017, In: Clinical and Translational Immunology. 6, 12, 7 p., e162.

    Research output: Contribution to journal › Review › Research › peer-review

  40. Published

    Unaffected bone mineral density in Danish children and adolescents with type 1 diabetes

    Madsen, J. O. B., Herskin, C. W., Zerahn, B., Jensen, Andreas Kryger, Jørgensen, Niklas Rye, Olsen, B. S., Pociot, Flemming & Johannesen, Jesper, 2020, In: Journal of Bone and Mineral Metabolism. p. 328–337 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Variation within the PPARG gene is associated with residual beta-cell function and glycemic control in children and adolescents during the first year of clinical type 1 diabetes

    Porksen, S., Nielsen, L. B., Mortensen, H. B., Danne, T., Kocova, M., Castano, L., Pociot, Flemming, Hougaard, P., Ekstrom, C. T., Gammeltoft, S., Knip, M. & Hansen, L., 2008, In: Pediatric Diabetes Online. 9, 4, p. 297-302 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Zinc transporter gene expression is regulated by pro-inflammatory cytokines: A potential role for zinc transporters in beta-cell apoptosis?

    Egefjord, L., Jensen, J. L., Bang-Berthelsen, C. H., Petersen, A. B., Smidt, K., Schmitz, O., Karlsen, A. E., Pociot, Flemming, Chimienti, F., Rungby, J. & Magnusson, N. E., 2009, In: BMC Endocrine Disorders. 9

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells

    Yasmeen, S., Kaur, S., Mirza, A. H., Larsen, Birger Brodin, Pociot, Flemming & Kruuse, Christina Rostrup, Aug 2019, In: Molecular Neurobiology. 56, 8, p. 5304–5314

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    miRNAs regulate development and function of regulatory T-cells in recent onset islet autoimmunity in pre-Type 1 diabetes

    Kaur, S. & Pociot, Flemming, 2018, In: Non-Coding RNA Investigation. 2, 5 p., 16.

    Research output: Contribution to journal › Editorial › Research

  45. Published

    Ætiologi og patogenese, Type 1

    Bergholdt, R., Larsen, C. M., Pociot, Flemming, Mandrup-Poulsen, Thomas, Hilsted, J. C., Christensen, J. S. & Borch-Johnsen, K., 2007, Diabetes. 1 ed. København: Handelshøjskolens Forlag, Vol. 6. p. -

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  46. Published

    β Cell and Autophagy: What Do We Know?

    Mohammadi-Motlagh, H. R., Sadeghalvad, M., Yavari, Niloofar, Primavera, R., Soltani, S., Chetty, S., Ganguly, A., Regmi, S., Fløyel, T., Kaur, S., Mirza, A. H., Thakor, A. S., Pociot, Flemming & Yarani, R., 2023, In: Biomolecules. 13, 4, 649.

    Research output: Contribution to journal › Review › Research › peer-review

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