Filip Krag Knop
Clinical Professor
Department of Clinical Medicine
Borgmester Ib Juuls Vej 1, 2730 Herlev
Member of:
Internal Medicine: Endocrinology
- 2003
- Published
No hypoglycemia after subcutaneous administration of glucagon-like peptide-1 in lean type 2 diabetic patients and in patients with diabetes secondary to chronic pancreatitis.
Knop, Filip Krag, Vilsbøll, Tina, Larsen, S., Madsbad, Sten, Holst, J. J. & Krarup, T., 2003, In: Diabetes Care. 26, 9, p. 2581-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small-bowel hemangiosarcoma and capsule endoscopy
Knop, Filip Krag, Hansen, M. B. & Meisner, S., 1 Jul 2003, In: Endoscopy. 35, 7, p. 637Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype
Vilsbøll, Tina, Knop, Filip Krag, Krarup, T., Johansen, A., Madsbad, Sten, Larsen, S., Hansen, T., Pedersen, O., Holst, J. M. & Johansen, A., 1 Oct 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 10, p. 4897-903 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Self-expanding metal stents for colonic obstruction: experiences from 104 procedures in a single center
Meisner, S., Hensler, M., Knop, Filip Krag, West, F. & Wille-Jørgensen, P., 1 Apr 2004, In: Diseases of the Colon and Rectum. 47, 4, p. 444-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delayed ischemic cecal perforation despite optimal decompression after placement of a self-expanding metal stent: report of a case
Knop, Filip Krag, Pilsgaard, B., Meisner, S. & Wille-Jørgensen, P., 1 Nov 2004, In: Diseases of the Colon and Rectum. 47, 11, p. 1970-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
Schisler, J. C., Jensen, P. B., Harper, D. A. T., Becker, T., Knop, Filip Krag, Takekawa, S., German, M., Weir, G. C., Lu, D., Mirmira, R. G. & Newgard, C. B., 17 May 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 20, p. 7297-302 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Vaerdien af billeddiagnostiske undersøgelser ordineret i almen praksis
Knop, Filip Krag & Stauning, J. A., 20 Feb 2006, In: Ugeskrift for Laeger. 168, 8, p. 794-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
Knop, Filip Krag, Vilsbøll, T., Madsbad, Sten, Holst, Jens Juul & Krarup, T., Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
Knop, F. K., Vilsbøll, Tina, Madsbad, Sten, Holst, Jens Juul, Krarup, T., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Holst, J. M. & Krarup, T., 1 Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Betydningen af inkretinhormonerne glucose-dependent insulinotropic peptide og glucagon-like peptide-1 for patogenesen ved type 2-diabetes mellitus
Vilsbøll, Tina & Knop, Filip Krag, 28 May 2007, In: Ugeskrift for Laeger. 169, 22, p. 2101-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide 1-baseret behandling af type 2-diabetes mellitus
Knop, Filip Krag & Vilsbøll, Tina, 28 May 2007, In: Ugeskrift for Laeger. 169, 22, p. 2095-9 5 p.Research output: Contribution to journal › Review › Research › peer-review
- 2008
- Published
Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
Højberg, P. V., Vilsbøll, Tina, Rabøl, R., Knop, Filip Krag, Bache, M., Krarup, T., Holst, Jens Juul & Madsbad, Sten, 2008, In: Diabetologia. 52, 2, p. 199-207 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
Aaboe, K., Knop, Filip Krag, Vilsboll, T., Vølund, A., Simonsen, U., Deacon, Carolyn F., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2008, In: Journal of Clinical Endocrinology and Metabolism. 94, 2, p. 603-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Positioning Glucagon-like-peptide-1-based Treatment within an Optimal Manegement Regimen for Type 2 Diabetes
Hansen, K. B., Vilsboll, T. & Knop, Filip Krag, 2008, In: European Journal of Endocrinology. Supplement. 4, p. 44-47 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-acting GLP-1 analogs for the treatment of type 2 diabetes mellitus
Vilsbøll, Tina & Knop, Filip Krag, 1 Jan 2008, In: BioDrugs. 22, 4, p. 251-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes
Højberg, P. V., Zander, M., Vilsbøll, T., Knop, Filip Krag, Krarup, T., Vølund, A., Holst, Jens Juul & Madsbad, Sten, 1 Apr 2008, In: Diabetologia. 51, 4, p. 632-640 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility
Knop, Filip Krag, Holst, Jens Juul & Vilsbøll, T., Jul 2008, In: I Drugs: the Investigational Drugs Journal. 11, 7, p. 497-501 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes
Højberg, P. V., Vilsbøll, T., Zander, M., Knop, Filip Krag, Krarup, T., Vølund, A., Holst, Jens Juul & Madsbad, Sten, Nov 2008, In: Diabetic Medicine Online. 25, 11, p. 1268-75 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes
Højberg, P. V., Vilsbøll, Tina, Zander, P. M., Knop, Filip Krag, Krarup, T., Vølund, A., Holst, J. M. & Madsbad, Sten, 1 Nov 2008, In: Diabetic Medicine. 25, 11, p. 1268-75 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Glucagon-like peptide-1 and diabetes treatment
Vilsbøll, Tina, Hare, K., Bagger, J. O. & Knop, Filip Krag, 2009, In: International Diabetes Monitor. 21, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incretin hormones and diabetes mellitus
Vilsbøll, Tina, Knop, Filip Krag, Deacon, Carolyn F. & Holst, Jens Juul, 2009, Therapeutic Strategies in Diabetes. Stehouwer, C. D. A. & Schaper, N. (eds.). Oxford: Clinical Publishing, p. 99-114Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Incretin-based therapy of type 2 diabetes mellitus
Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2009, In: Current Protein and Peptide Science. 10, 1, p. 46-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide (GIP) in patients with type 2 diabetes
Aaboe, K., Knop, Filip Krag, Vilsbøll, Tina, Vølund, A., Simonsen, U., Deacon, Carolyn F., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 2, p. 603-608Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus
Christensen, M., Knop, Filip Krag, Holst, Jens Juul & Vilsboll, T., 2009, In: IDrugs. The Investigational Drugs Journal. 12, 8, p. 503-13 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus
Hare, K. J., Knop, Filip Krag, Asmar, M., Madsbad, Sten, Deacon, Carolyn F., Holst, Jens Juul & Vilsbøll, Tina, 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 12, p. 4679-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resolution of type 2 diabetes following gastric bypass surgery: involvement of gut-derived glucagon and glucagonotropic signalling?
Knop, Filip Krag, 2009, In: Diabetologia. 52, 11, p. 2270-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The spectrum of antidiabetic actions of GLP-1 in patients with diabetes
Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2009, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 23, 4, p. 453-62 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists
Hansen, K. B., Knop, Filip Krag, Holst, Jens Juul & Vilsbøll, Tina, 2009, In: International Journal of Clinical Practice. 63, 8, p. 1154-60 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Increased Postprandial Response of Glucagon-Like Peptide-2 in Patients with Chronic Pancreatitis and Pancreatic Exocrine Insufficiency
Hornum, Mads, Pedersen, J. F., Larsen, S., Olsen, O., Holst, Jens Juul & Knop, Filip Krag, 2010, In: Pancreatology. 10, 2-3, p. 201-207 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose- and non-glucose-induced insulin secretion in patients with type 2 diabetes mellitus
Aaboe, K., Knop, Filip Krag, Vilsbøll, Tina, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2010, In: Diabetes, Obesity and Metabolism. 12, 4, p. 323-333 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incretin mimetics: a novel therapeutic option for patients with type 2 diabetes - a review
Hansen, K. B., Vilsbøll, Tina & Knop, Filip Krag, 1 Jan 2010, In: Diabetes, Metabolic Syndrome and Obesity. 3, p. 155-63 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Incretin-based therapy and type 2 diabetes
Hare, K. J. & Knop, Filip Krag, 1 Jan 2010, In: Vitamins and Hormones. 84, p. 389-413 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes
Hare, K. J., Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 1 Apr 2010, In: American Journal of Physiology: Endocrinology and Metabolism. 298, 4, p. E832-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Once-weekly GLP-1 agonists: How do they differ from exenatide and liraglutide?
Christensen, M. & Knop, Filip Krag, 1 Apr 2010, In: Current Diabetes Reports. 10, 2, p. 124-32 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus
Aaboe, K., Knop, Filip Krag, Vilsbøll, T., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S. & Krarup, T. M., 1 Apr 2010, In: Diabetes, Obesity and Metabolism. 12, 4, p. 323-33 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?
Asmar, M., Bache, M., Knop, Filip Krag, Madsbad, Sten & Holst, Jens Juul, 1 May 2010, In: The Journal of clinical endocrinology and metabolism. 95, 5, p. 2367-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comment on: Villareal et al. (2009) TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes;59:479-485
Knop, Filip Krag, 1 Jun 2010, In: Diabetes. 59, 6, p. e4; author reply e5-6Research output: Contribution to journal › Letter › Research › peer-review
- Published
Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?
Knop, Filip Krag, 1 Jul 2010, In: American Journal of Physiology: Endocrinology and Metabolism. 299, 1, p. E10-3Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incretin hormones and beta cell function in chronic pancreatitis
Knop, Filip Krag, 1 Jul 2010, In: Danish Medical Bulletin (Online). 57, 7, p. B4163Research output: Contribution to journal › Review › Research › peer-review
- Published
Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects
Hansen, K. B., Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 1 Jul 2010, In: The Journal of clinical endocrinology and metabolism. 95, 7, p. 3309-17 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action
Hare, K. J., Vilsbøll, Tina, Asmar, M., Deacon, Carolyn F., Knop, Filip Krag & Holst, Jens Juul, 1 Jul 2010, In: Diabetes. 59, 7, p. 1765-70 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes
Christensen, M., Knop, Filip Krag, Vilsbøll, Tina, Aaboe, K., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 9 Aug 2010, In: Regulatory Peptides. 163, 1-3, p. 96-101 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of pancreatic enzyme supplementation on postprandial responses of glucagon-like Peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency
Knop, Filip Krag, Vilsbøll, Tina, Lund, A., Krarup, T., Holst, Jens Juul & Hornum, Mads, 6 Sep 2010, In: Journal of the Pancreas. 11, 5, p. 489-91 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis
Knop, Filip Krag, Vilsbøll, Tina, Larsen, S., Madsbad, Sten, Holst, Jens Juul & Krarup, T. M., 24 Sep 2010, In: Regulatory Peptides. 164, 2-3, p. 144-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes
Solem, Espen Victor Jimenez, Rasmussen, M. H., Christensen, M. & Knop, Filip Krag, 1 Dec 2010, In: Current Opinion in Molecular Therapeutics. 12, 6, p. 790-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans
Hansen, K. B., Rosenkilde, Mette, Knop, Filip Krag, Wellner, N., Diep, T. A., Rehfeld, Jens Frederik, Andersen, U. B., Holst, Jens Juul & Hansen, Harald S., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1409-17Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Emerging GLP-1 receptor agonists
Lund, A., Knop, Filip Krag & Vilsbøll, Tina, 2011, In: Expert Opinion on Emerging Drugs. 16, 4, p. 607-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
First case associating chronic pancreatitis and Ehlers-Danlos syndrome
Hansen, K. B. & Knop, Filip Krag, 2011, In: Pancreas. 40, 1Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gastric emptying of orally administered glucose solutions and incretin hormone responses are unaffected by laparoscopic adjustable gastric banding
Usinger, Lotte, Hansen, K. B., Kristiansen, V. B., Larsen, S., Holst, Jens Juul & Knop, Filip Krag, 2011, In: Obesity Surgery. 21, 5, p. 625-32 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans
Christensen, M., Vedtofte, L., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2011, In: Diabetes. 60, 12, p. 3103-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 40100368
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L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
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