Jens Bukh

Jens Bukh

Professor

Member of:


    1. Published

      Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77

      Li, Y., Ramirez Almeida, Santseharay, Mikkelsen, L. & Bukh, Jens, Jan 2015, In: Journal of Virology. 89, 1, p. 811-23 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Published

      Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against specific antagomir

      Li, Y., Pham, Long, Uzcategui, N. & Bukh, Jens, Jun 2016, In: Journal of General Virology. 97, p. 1381-1394

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR

      Li, Y., Gottwein, J., Scheel, Troels Kasper Høyer, Jensen, T. B. & Bukh, Jens, 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 4991-4996

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model

      Liang, T. J., Law, J. L. M., Pietschmann, T., Ray, S. C., Bukh, Jens, Bull, R., Chung, R. T., Tyrrell, D. L., Houghton, M. & Rice, C. M., 2023, In: Clinical Infectious Diseases. 77, p. S257-S261

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine

      Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, Ulrik, Bukh, Jens, Gottwein, Judith Margarete & Wolff, M. W., 2020, In: Scientific Reports. 10, 13 p., 16261.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C

      Madsen, L. W., Christensen, P. B., Fahnøe, Ulrik, Pedersen, M. S., Bukh, Jens & Øvrehus, A., 2021, In: Liver International. 41, 11, p. 2601-2610

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Hepatitis C virus alters the morphology and function of peroxisomes

      Martin de Fourchambault, E., Callens, N., Saliou, J. M., Fourcot, M., Delos, O., Barois, N., Thorel, Q., Ramirez Almeida, Santseharay, Bukh, Jens, Cocquerel, L., Bertrand-Michel, J., Marot, G., Sebti, Y., Dubuisson, J. & Rouillé, Y., 2023, In: Frontiers in Microbiology. 14, 1254728.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death.

      Mateu, G., Donis, R. O., Wakita, T., Bukh, Jens & Grakoui, A., 2008, In: Virology. 376, 2, p. 397-407 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6

      Mathiesen, C. K., Jensen, T. B., Prentø, Jannick, Krarup, H., Nicosia, A., Law, M., Bukh, Jens & Gottwein, Judith Margarete, Jun 2014, In: Virology. 458-459, p. 190-208 19 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

      Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

      Mejer, N., Galli, Andrea, Ramirez Almeida, Santseharay, Fahnøe, Ulrik, Benfield, Thomas & Bukh, Jens, 2020, In: Virology. 540, p. 132-140 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Ribavirin-induced mutagenesis across the complete open reading frame of hepatitis C virus genotypes 1a and 3a

      Mejer, N., Fahnøe, Ulrik, Galli, Andrea, Ramirez Almeida, Santseharay, Benfield, Thomas & Bukh, Jens, 2018, In: Journal of General Virology. 99, 8, p. 1066-1077 12 p., 001095.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity

      Mejer, N., Fahnøe, Ulrik, Galli, Andrea, Ramirez Almeida, Santseharay, Weiland, O., Benfield, Thomas & Bukh, Jens, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 12

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

      Meuleman, P., Bukh, Jens, Verhoye, L., Farhoudi, A., Vanwolleghem, T., Wang, R. Y., Desombere, I., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2011, In: Hepatology. 53, 3, p. 755-62

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus

      Meunier, J., Russell, R. S., Goossens, V., Priem, S., Walther, H., Depla, E., Union, A., Faulk, K. N., Bukh, Jens, Emerson, S. U. & Purcell, R. E., 2008, In: Journal of Virology. 82, 2, p. 966-73 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

      Meunier, J., Bukh, Jens, Diaz, G., Tovo, P., Casadei, A. M., Quinti, I., Iorio, R., Emerson, S., Purcell, R. H. & Farci, P., 2011, In: Journal of Infectious Diseases. 204, 11, p. 1741-5 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

      Meunier, J., Gottwein, J. M., Houghton, M., Russell, R. S., Emerson, S. U., Bukh, Jens & Purcell, R. H., 2011, In: Journal of Infectious Diseases. 204, 8, p. 1186-90 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain

      Mikkelsen, M., Holst, Peter Johannes, Bukh, Jens, Thomsen, Allan Randrup & Christensen, Jan Pravsgaard, 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2355-64 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Current status of a hepatitis C vaccine: encouraging results but significant challenges ahead

      Mikkelsen, M. & Bukh, Jens, 2007, In: Current Infectious Disease Reports. 9, 2, p. 94-101 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease

      Mullari, M., Fossat, Nicolas Julien, Skotte, Niels Henning, Asenjo-Martinez, A., Humphreys, D. T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels Kasper Høyer & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 20 p., 4348.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Sars-cov-2 production in a scalable high cell density bioreactor

      Offersgaard, Anna Falden, Hernandez, C. R. D., Pihl, A. F., Costa, Rui, Venkatesan, N. P., Lin, X., Pham, Long, Feng, S., Fahnøe, Ulrik, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2021, In: Vaccines. 9, 7, 706.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Toward a vaccine against hepatitis C virus

      Offersgaard, Anna Falden, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Science. 380, 6640, p. 37-38 2 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published
    24. Published

      High‐Titer Hepatitis C Virus Production in a Scalable Single‐Use High Cell Density Bioreactor

      Offersgaard, Anna Falden, Duarte Hernandez, C. R., Finne Pihl, A., Prabhakar Venkatesan, N., Krarup, H., Lin, X., Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2022, In: Vaccines. 10, 2, 249.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Establishment of high-titer HCV and SARS-CoV-2 production in a scalable packed-bed bioreactor for inactivated vaccines inducing neutralizing antibodies in animals

      Offersgaard, A. F., Hernandez, C. R. D., Finne Pihl, A., Feng, S., Marichal-Gallardo, P., Venkatesan, N. P., Lin, X., Fernandez-Antunez, C., Pena Alzua, G., Costa, R., Hartmann, K. T., Pham, L., Zhou, Y., Gammeltoft, K. A., Fahnøe, U., Scheel, T. K. H., Schneider, U. V., Jensen, H. E., Christensen, J. P., Ramirez Almeida, S. & 4 others, Reichl, U., Genzel, Y., Bukh, Jens & Gottwein, Judith Margarete, 6 Jul 2022.

      Research output: Contribution to conferencePosterCommunication

    ID: 12437