Acetylation regulates WRN catalytic activities and affects base excision DNA repair

Research output: Contribution to journalJournal articleResearchpeer-review

Meltem Muftuoglu, Rika Kusumoto, Elzbieta Speina, Gad Beck, Wen-Hsing Cheng, Vilhelm A Bohr

The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.
Original languageEnglish
JournalP L o S One
Volume3
Issue number4
Pages (from-to)e1918
ISSN1932-6203
DOIs
Publication statusPublished - Jan 2008

    Research areas

  • Aging, Catalysis, Cell Line, DNA, DNA Damage, DNA Repair, Exodeoxyribonucleases, Exonucleases, Hela Cells, Histone Acetyltransferases, Humans, Protein Processing, Post-Translational, Protein Structure, Tertiary, RecQ Helicases, Recombinant Proteins, Transcription, Genetic

ID: 32949176