Acetylation regulates WRN catalytic activities and affects base excision DNA repair
Research output: Contribution to journal › Journal article › Research › peer-review
The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.
| Original language | English |
|---|---|
| Journal | P L o S One |
| Volume | 3 |
| Issue number | 4 |
| Pages (from-to) | e1918 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - Jan 2008 |
- Aging, Catalysis, Cell Line, DNA, DNA Damage, DNA Repair, Exodeoxyribonucleases, Exonucleases, Hela Cells, Histone Acetyltransferases, Humans, Protein Processing, Post-Translational, Protein Structure, Tertiary, RecQ Helicases, Recombinant Proteins, Transcription, Genetic
Research areas
ID: 32949176