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Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors. / Larsen, Morten; Hansen, Cecilie Hurup; Rasmussen, Tobias B.; Styrishave, Bjarne; Olsen, Lars; Jørgensen, Flemming Steen.
In:
Chemical Communications, Vol. 53, No. 3118, 3118, 28.02.2017.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Larsen, M, Hansen, CH, Rasmussen, TB
, Styrishave, B, Olsen, L
& Jørgensen, FS 2017, '
Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors',
Chemical Communications, vol. 53, no. 3118, 3118.
https://doi.org/10.1039/C6CC08680BAPA
Larsen, M., Hansen, C. H., Rasmussen, T. B.
, Styrishave, B., Olsen, L.
, & Jørgensen, F. S. (2017).
Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors.
Chemical Communications,
53(3118), [3118].
https://doi.org/10.1039/C6CC08680BVancouver
Larsen M, Hansen CH, Rasmussen TB
, Styrishave B, Olsen L
, Jørgensen FS.
Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors.
Chemical Communications. 2017 Feb 28;53(3118). 3118.
https://doi.org/10.1039/C6CC08680BAuthor
Larsen, Morten ; Hansen, Cecilie Hurup ; Rasmussen, Tobias B. ; Styrishave, Bjarne ; Olsen, Lars ; Jørgensen, Flemming Steen. / Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors. In: Chemical Communications. 2017 ; Vol. 53, No. 3118.
Bibtex
@article{ad5f931a62fe444692aab7b74aaa24da,
title = "Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors",
abstract = "Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.",
author = "Morten Larsen and Hansen, {Cecilie Hurup} and Rasmussen, {Tobias B.} and Bjarne Styrishave and Lars Olsen and J{\o}rgensen, {Flemming Steen}",
year = "2017",
month = feb,
day = "28",
doi = "10.1039/C6CC08680B",
language = "English",
volume = "53",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "3118",
}
RIS
TY - JOUR
T1 - Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors
AU - Larsen, Morten
AU - Hansen, Cecilie Hurup
AU - Rasmussen, Tobias B.
AU - Styrishave, Bjarne
AU - Olsen, Lars
AU - Jørgensen, Flemming Steen
PY - 2017/2/28
Y1 - 2017/2/28
N2 - Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.
AB - Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.
U2 - 10.1039/C6CC08680B
DO - 10.1039/C6CC08680B
M3 - Journal article
VL - 53
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 3118
M1 - 3118
ER -
