Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors

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Five new non-steroidal inhibitors for cytochrome P450 17A1 (CYP17A1) were identified by structure-based optimisation from a recently identified selective CYP17A1 inhibitor. The compounds are nanomolar inhibitors of steroidogenesis measured in recombinant CYP17A1 and in H295R cells.
Original languageEnglish
Article number3118
JournalChemical Communications
Issue number3118
Number of pages4
Publication statusPublished - 28 Feb 2017

ID: 174130515