Life course of retrospective harmonization initiatives: key elements to consider

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  • Isabel Fortier
  • Tina W. Wey
  • Julie Bergeron
  • Pinot de Moira, Angela
  • Nybo Andersen, Anne-Marie
  • Tom Bishop
  • Madeleine J. Murtagh
  • Milica Miocevic
  • Morris A. Swertz
  • Esther van Enckevort
  • Yannick Marcon
  • Michaela. Th. Mayrhofer
  • Jos Pedro Ornelas
  • Sylvain Sebert
  • Ana Cristina Santos
  • Artur Rocha
  • Rebecca C. Wilson
  • Lauren E. Griffith
  • Paul Burton

Optimizing research on the developmental origins of health and disease (DOHaD) involves implementing initiatives maximizing the use of the available cohort study data; achieving sufficient statistical power to support subgroup analysis; and using participant data presenting adequate follow-up and exposure heterogeneity. It also involves being able to undertake comparison, cross-validation, or replication across data sets. To answer these requirements, cohort study data need to be findable, accessible, interoperable, and reusable (FAIR), and more particularly, it often needs to be harmonized. Harmonization is required to achieve or improve comparability of the putatively equivalent measures collected by different studies on different individuals. Although the characteristics of the research initiatives generating and using harmonized data vary extensively, all are confronted by similar issues. Having to collate, understand, process, host, and co-analyze data from individual cohort studies is particularly challenging. The scientific success and timely management of projects can be facilitated by an ensemble of factors. The current document provides an overview of the 'life course' of research projects requiring harmonization of existing data and highlights key elements to be considered from the inception to the end of the project.

Original languageEnglish
JournalJournal of Developmental Origins of Health and Disease
Issue number2
Number of pages9
Publication statusPublished - 2023

    Research areas

  • Data harmonization, data processing, longitudinal data, cohort studies, Developmental Origins of Health and Disease (DOHAD), DEVELOPMENTAL ORIGINS, POOLED ANALYSES, HEALTH, PREGNANCY

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