Compaction Properties of Particulate Proteins in Binary Powder Mixtures with Common Excipients

Research output: Contribution to journalJournal articleResearchpeer-review


  • Fulltext

    Final published version, 1.28 MB, PDF document

The increasing interest in protein- and peptide-based oral pharmaceuticals has culminated in the first protein-based products for oral delivery becoming commercially available. This study investigates the compaction properties of proteins in binary mixtures with common excipients up to 30% (w/w) of particulate protein. Two model proteins, lysozyme and bovine serum albumin, were compacted with either microcrystalline cellulose, spray-dried lactose monohydrate, or calcium hydrogen phosphate dihydrate at two different compaction pressures. Compared to the compacted pure materials, a significant increase in the tensile strength of the compacts was observed for the binary blends containing lysozyme together with the brittle excipients. This could be attributed to the increased bonding forces between the particles in the blend compared to the pure materials. The use of bovine serum albumin with a larger particle size resulted in a decrease in tensile strength for all the compacts. The change in the tensile strength with an increasing protein content was non-linear for both proteins. This work highlights the importance of considering the particulate properties of protein powders and that protein-based compacts can be designed with similar principles as small-molecules in terms of their mechanical tablet properties.

Original languageEnglish
Article number19
Issue number1
Number of pages11
Publication statusPublished - 2024

Bibliographical note

Funding Information:
This research was funded by Innovation Fund Denmark, project High-Quality Dry Products with Superior Functionality and Stability—Q-Dry, grant number 5150-0024B.

Publisher Copyright:
© 2023 by the authors.

    Research areas

  • compaction, pharmaceutical, powder properties, protein, tableting

ID: 382398988