Beneficial role of antioxidants on clinical outcomes and erythrocyte antioxidant parameters in rheumatoid arthritis patients

Research output: Contribution to journalJournal articleResearchpeer-review

  • Jalili, Mahsa
  • Sousan Kolahi
  • Seyed Rafi Aref-Hosseini
  • Mehrangiz Ebrahimi Mamegani
  • Azita Hekmatdoost

Background: This study aims to investigate the effect of antioxidants supplement on clinical outcomes and antioxidant parameters in rheumatoid arthritis (RA). Methods: The pre-post study was conducted on 40 female patients with RA in 12 weeks that taken daily one "Selenplus" capsule contained 50 μg selenium, 8 mg zinc, 400 μg vitamin A, 125 mg vitamin C, and 40 mg vitamin E. About 5 mL venous blood sample was taken from all participants and disease activity score (DAS) was determined by DAS-28 formula and high-sensitive C-reactive protein (hs-CRP). Glutathione peroxidase (GPX) and superoxide dismutase (SOD) were measured by spectrophotometric kit and catalase (CAT) was measured by Abei method. Total antioxidant capacity (TAC) was determined by spectrophotometric kit. Distribution of the variables was assessed using histogram with normal curve as well as Kolmogorov-Smirnov test and data were analyzed with paired t-test for differences between pre-post data using SPSS software version 13.5. Results: Out of 40 patients, 39 completed the study. DAS-28 score and hs-CRP have changed (P < 0.01 for both), while the number of swollen and painful joints did not reduce significantly. TAC, GPX, SOD, and CAT increased significantly (P < 0.01 for all variables). Conclusions: Our findings showed that antioxidants may improve disease activity significantly, but it did not affect the number of painful and swollen joints and increased erythrocyte antioxidant levels. Antioxidants may be useful for controlling of clinical outcomes and oxidative stress in RA.

Original languageEnglish
JournalInternational Journal of Preventive Medicine
Issue number7
Pages (from-to)835-840
Number of pages6
Publication statusPublished - 2014
Externally publishedYes

    Research areas

  • Antioxidants, Dietary supplements, Nutrition, Oxidative stress, Rheumatoid arthritis

ID: 248338849