An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles

Research output: Contribution to journalJournal articleResearchpeer-review

  • Spomenka Simovic
  • He Hui
  • Yunmei Song
  • Andrew K Davey
  • Rades, Thomas
  • Clive A Prestidge
We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p
Original languageEnglish
JournalJournal of controlled release : official journal of the Controlled Release Society
Issue number3
Pages (from-to)367-73
Number of pages7
Publication statusPublished - 2010

    Research areas

  • Administration, Oral, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cations, Drug Carriers, Emulsions, Indomethacin, Lipids, Male, Nanoparticles, Rats, Rats, Sprague-Dawley, Silicon Dioxide

ID: 40348702