An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. / Simovic, Spomenka; Hui, He; Song, Yunmei; Davey, Andrew K; Rades, Thomas; Prestidge, Clive A.

In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 143, No. 3, 2010, p. 367-73.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Simovic, S, Hui, H, Song, Y, Davey, AK, Rades, T & Prestidge, CA 2010, 'An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles', Journal of controlled release : official journal of the Controlled Release Society, vol. 143, no. 3, pp. 367-73. https://doi.org/10.1016/j.jconrel.2010.01.008

APA

Simovic, S., Hui, H., Song, Y., Davey, A. K., Rades, T., & Prestidge, C. A. (2010). An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. Journal of controlled release : official journal of the Controlled Release Society, 143(3), 367-73. https://doi.org/10.1016/j.jconrel.2010.01.008

Vancouver

Simovic S, Hui H, Song Y, Davey AK, Rades T, Prestidge CA. An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. Journal of controlled release : official journal of the Controlled Release Society. 2010;143(3):367-73. https://doi.org/10.1016/j.jconrel.2010.01.008

Author

Simovic, Spomenka ; Hui, He ; Song, Yunmei ; Davey, Andrew K ; Rades, Thomas ; Prestidge, Clive A. / An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. In: Journal of controlled release : official journal of the Controlled Release Society. 2010 ; Vol. 143, No. 3. pp. 367-73.

Bibtex

@article{6dd12d01a1d24b8394fccced1ccff884,

title = "An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles",

abstract = "We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p",

keywords = "Administration, Oral, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cations, Drug Carriers, Emulsions, Indomethacin, Lipids, Male, Nanoparticles, Rats, Rats, Sprague-Dawley, Silicon Dioxide",

author = "Spomenka Simovic and He Hui and Yunmei Song and Davey, {Andrew K} and Thomas Rades and Prestidge, {Clive A}",

year = "2010",

doi = "10.1016/j.jconrel.2010.01.008",

language = "English",

volume = "143",

pages = "367--73",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles

AU - Simovic, Spomenka

AU - Hui, He

AU - Song, Yunmei

AU - Davey, Andrew K

AU - Rades, Thomas

AU - Prestidge, Clive A

PY - 2010

Y1 - 2010

N2 - We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p

AB - We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p

KW - Administration, Oral

KW - Animals

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Cations

KW - Drug Carriers

KW - Emulsions

KW - Indomethacin

KW - Lipids

KW - Male

KW - Nanoparticles

KW - Rats

KW - Rats, Sprague-Dawley

KW - Silicon Dioxide

U2 - 10.1016/j.jconrel.2010.01.008

DO - 10.1016/j.jconrel.2010.01.008

M3 - Journal article

C2 - 20079390

VL - 143

SP - 367

EP - 373

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

IS - 3

ER -

ID: 40348702