Xanthomonas citri pv. citri pathotypes: LPS structure and function as microbe-associated molecular patterns
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Xanthomonas citri pv. citri pathotypes : LPS structure and function as microbe-associated molecular patterns. / Di Lorenzo, Flaviana; Silipo, Alba; Gersby, Lotte Bettina Andersen; Palmigiano, Angelo; Lanzetta, Rosa; Garozzo, Domenico; Boyer, Claudine; Pruvost, Olivier; Newman, Mari-Anne; Molinaro, Antonio.
In: ChemBioChem, Vol. 18, No. 8, 2017, p. 772-781.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Xanthomonas citri pv. citri pathotypes
T2 - LPS structure and function as microbe-associated molecular patterns
AU - Di Lorenzo, Flaviana
AU - Silipo, Alba
AU - Gersby, Lotte Bettina Andersen
AU - Palmigiano, Angelo
AU - Lanzetta, Rosa
AU - Garozzo, Domenico
AU - Boyer, Claudine
AU - Pruvost, Olivier
AU - Newman, Mari-Anne
AU - Molinaro, Antonio
N1 - © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2017
Y1 - 2017
N2 - Xanthomonas citri pv. citri is the pathogen responsible for Asiatic citrus canker, one of the most serious citrus diseases worldwide. The lipopolysaccharide (LPS) molecule has been demonstrated to be involved in X. citri pv. citri virulence. Despite enormous progress in investigations of the molecular mechanisms for bacterial pathogenicity, determination of the detailed LPS structure-activity relationship is limited, as the current knowledge is mainly based on structural determination of one X. citri pv. citri strain. As X. citri pv. citri strains are distinguished into three main pathogenicity groups, we characterized the full structure of the LPS from two pathotypes that differ in their host-range specificity. This revealed an intriguing difference in LPS O-chain structure. We also tested the LPSs and isolated lipid A moieties for their ability to act as microbe-associated molecular patterns in Arabidopsis thaliana. Both LPS/lipid As induced ROS accumulation, but no difference was observed between the two pathotypes.
AB - Xanthomonas citri pv. citri is the pathogen responsible for Asiatic citrus canker, one of the most serious citrus diseases worldwide. The lipopolysaccharide (LPS) molecule has been demonstrated to be involved in X. citri pv. citri virulence. Despite enormous progress in investigations of the molecular mechanisms for bacterial pathogenicity, determination of the detailed LPS structure-activity relationship is limited, as the current knowledge is mainly based on structural determination of one X. citri pv. citri strain. As X. citri pv. citri strains are distinguished into three main pathogenicity groups, we characterized the full structure of the LPS from two pathotypes that differ in their host-range specificity. This revealed an intriguing difference in LPS O-chain structure. We also tested the LPSs and isolated lipid A moieties for their ability to act as microbe-associated molecular patterns in Arabidopsis thaliana. Both LPS/lipid As induced ROS accumulation, but no difference was observed between the two pathotypes.
KW - Journal Article
U2 - 10.1002/cbic.201600671
DO - 10.1002/cbic.201600671
M3 - Journal article
C2 - 28186388
VL - 18
SP - 772
EP - 781
JO - ChemBioChem
JF - ChemBioChem
SN - 1439-4227
IS - 8
ER -
ID: 180762973