Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbations
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Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbations. / Ingebrigtsen, Truls S.; Marott, Jacob L.; Lange, Peter.
In: European Clinical Respiratory Journal, Vol. 7, No. 1, 1765543, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Witnessed sleep apneas together with elevated plasma glucose are predictors of COPD exacerbations
AU - Ingebrigtsen, Truls S.
AU - Marott, Jacob L.
AU - Lange, Peter
PY - 2020
Y1 - 2020
N2 - ObjectiveSleep apnea and elevated plasma glucose associates with inflammation which associates with the risk of COPD exacerbations. We investigated the risk of exacerbations in individuals with COPD, witnessed sleep apneas, and elevated plasma glucose.MethodsFrom the Copenhagen City Heart Study cohort, we identified 564 individuals with COPD (forced expiratory volume in 1 sec divided by forced vital capacity, FEV1/FVCResultsWe identified 74 (13%) individuals with sleep apnea without elevated plasma glucose, 70 (12%) had elevated plasma glucose (above 6.9 mM (>125 mg/dL)) without sleep apnea and 11 individuals had the presence of both conditions. In univariable analysis, witnessed apneas together with elevated plasma glucose had a high risk of exacerbations, hazard ratio (HR) = 5.81 (2.34-14.4, p = 0.0001) compared to those without sleep apnea and without elevated plasma glucose. Multivariable analysis, adjusting for several risk factors of exacerbations, showed a similar result, HR = 3.45 (1.13-10.5, p = 0.03). Both presence of sleep apnea without elevated plasma glucose and the presence of elevated plasma glucose without sleep apnea showed no associations with the risk of exacerbations.ConclusionsWitnessed sleep apneas in COPD are associated with increased risk of exacerbations, but only among those with elevated plasma glucose.
AB - ObjectiveSleep apnea and elevated plasma glucose associates with inflammation which associates with the risk of COPD exacerbations. We investigated the risk of exacerbations in individuals with COPD, witnessed sleep apneas, and elevated plasma glucose.MethodsFrom the Copenhagen City Heart Study cohort, we identified 564 individuals with COPD (forced expiratory volume in 1 sec divided by forced vital capacity, FEV1/FVCResultsWe identified 74 (13%) individuals with sleep apnea without elevated plasma glucose, 70 (12%) had elevated plasma glucose (above 6.9 mM (>125 mg/dL)) without sleep apnea and 11 individuals had the presence of both conditions. In univariable analysis, witnessed apneas together with elevated plasma glucose had a high risk of exacerbations, hazard ratio (HR) = 5.81 (2.34-14.4, p = 0.0001) compared to those without sleep apnea and without elevated plasma glucose. Multivariable analysis, adjusting for several risk factors of exacerbations, showed a similar result, HR = 3.45 (1.13-10.5, p = 0.03). Both presence of sleep apnea without elevated plasma glucose and the presence of elevated plasma glucose without sleep apnea showed no associations with the risk of exacerbations.ConclusionsWitnessed sleep apneas in COPD are associated with increased risk of exacerbations, but only among those with elevated plasma glucose.
KW - Sleep apnea
KW - glucose
KW - COPD
KW - severe exacerbations
KW - OBSTRUCTIVE PULMONARY-DISEASE
KW - METABOLIC SYNDROME
KW - HYPERGLYCEMIA
KW - INFLAMMATION
KW - OUTCOMES
KW - HEALTH
KW - DYSFUNCTION
KW - PREVALENCE
KW - BIOMARKERS
KW - OVERWEIGHT
U2 - 10.1080/20018525.2020.1765543
DO - 10.1080/20018525.2020.1765543
M3 - Journal article
C2 - 33224452
VL - 7
JO - European Clinical Respiratory Journal
JF - European Clinical Respiratory Journal
SN - 2001-8525
IS - 1
M1 - 1765543
ER -
ID: 252549970