Vitamin E and acute graft-versus-host disease after myeloablative allogeneic hematopoietic cell transplantation
Research output: Contribution to journal › Journal article › Research › peer-review
Objectives Vitamin E has antioxidant and immunomodulatory effects that might influence the development of acute graft-versus-host disease (GvHD). We investigated the association between plasma vitamin E levels and acute GvHD.
Methods We studied 115 adults who underwent myeloablative allogeneic hematopoietic cell transplantation between July 2015 and August 2018. Vitamin E was measured by high-performance liquid chromatography in stored plasma samples obtained pre-transplantation at day -23 (+/- 15 days) and post-transplantation at day +28 (+/- 3 days).
Results Pre-transplantation vitamin E levels were inversely associated with grade II-IV acute GvHD (hazard ratio 0.68 per 10 mu mol/L increase, 95% confidence interval [CI]: 0.47-0.98). The association remained after adjustment for known prognostic factors for acute GvHD. Patients with levels below the median had a cumulative incidence of grade II-IV acute GvHD of 46% (CI: 33-59%) versus 21% (CI: 10-32%) in patients with levels above the median. No clear association with non-relapse mortality, relapse, or chronic GvHD was found. Post-transplantation vitamin E levels (measured in 72 [63%] patients) were correlated with pre-transplantation levels (rho = .31) but were not associated with subsequent grade II-IV acute GvHD.
Conclusions High pre-transplantation vitamin E levels were associated with less acute GvHD.
Original language | English |
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Journal | European Journal of Haematology |
Volume | 106 |
Issue number | 3 |
Pages (from-to) | 417-424 |
ISSN | 0902-4441 |
DOIs | |
Publication status | Published - 2021 |
- acute graft‐, versus‐, host disease, allogeneic hematopoietic cell transplantation, vitamin E, T-HELPER-1 CYTOKINE PRODUCTION, HIGH-DOSE CHEMOTHERAPY, ALPHA-TOCOPHEROL, ANTIOXIDANT STATUS, PLASMA, SUPPLEMENTATION, ADHESION, RECIPIENTS, MUCOSITIS
Research areas
ID: 269916055