Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians

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Standard

Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. / Rasmussen, Søren K; Urhammer, Søren A; Berglund, Lars Erik; Jensen, Jan N; Hansen, Lars; Echwald, Søren Morgenthaler; Borch-Johnsen, Knut; Horikawa, Yukio; Mashima, Hirosato; Lithell, Hans; Cox, Nancy J; Hansen, Torben; Bell, Graeme I; Pedersen, Oluf.

In: Diabetes, Vol. 51, No. 12, 2002, p. 3561-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rasmussen, SK, Urhammer, SA, Berglund, LE, Jensen, JN, Hansen, L, Echwald, SM, Borch-Johnsen, K, Horikawa, Y, Mashima, H, Lithell, H, Cox, NJ, Hansen, T, Bell, GI & Pedersen, O 2002, 'Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians', Diabetes, vol. 51, no. 12, pp. 3561-7.

APA

Rasmussen, S. K., Urhammer, S. A., Berglund, L. E., Jensen, J. N., Hansen, L., Echwald, S. M., Borch-Johnsen, K., Horikawa, Y., Mashima, H., Lithell, H., Cox, N. J., Hansen, T., Bell, G. I., & Pedersen, O. (2002). Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. Diabetes, 51(12), 3561-7.

Vancouver

Rasmussen SK, Urhammer SA, Berglund LE, Jensen JN, Hansen L, Echwald SM et al. Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. Diabetes. 2002;51(12):3561-7.

Author

Rasmussen, Søren K ; Urhammer, Søren A ; Berglund, Lars Erik ; Jensen, Jan N ; Hansen, Lars ; Echwald, Søren Morgenthaler ; Borch-Johnsen, Knut ; Horikawa, Yukio ; Mashima, Hirosato ; Lithell, Hans ; Cox, Nancy J ; Hansen, Torben ; Bell, Graeme I ; Pedersen, Oluf. / Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. In: Diabetes. 2002 ; Vol. 51, No. 12. pp. 3561-7.

Bibtex

@article{243160f2b3844d93a1ee90b9684d6f8d,
title = "Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians",
abstract = "Variations in the calpain-10 gene (CAPN10) have been identified among Mexican-Americans, and an at-risk haplotype combination (112/121) defined by three polymorphisms, UCSNP-43, -19, and -63, confers increased risk of type 2 diabetes. Here we examine the three polymorphisms in 1,594 Scandinavian subjects, including 409 type 2 diabetic patients, 200 glucose-tolerant control subjects, 322 young healthy subjects, 206 glucose-tolerant offspring of diabetic patients, and 457 glucose-tolerant 70-year-old men. The frequency of the 112/121 combination was not significantly different in 409 type 2 diabetic subjects compared with 200 glucose-tolerant control subjects (0.06 vs. 0.05; odds ratio 1.32 [95% CI 0.58-3.30]). In glucose-tolerant subjects, neither the single-nucleotide polymorphisms individually nor the 112/121 combination were associated with alterations in plasma glucose, serum insulin, or serum C-peptide levels at fasting or during an oral glucose tolerance test, estimates of insulin sensitivity, or glucose-induced insulin secretion. In conclusion, the frequency of the 112/121 at-risk haplotype of CAPN10 is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and type 2 diabetes, insulin resistance, or impaired insulin secretion.",
keywords = "Adult, Aged, Aged, 80 and over, Calpain, Chromosomes, Human, Pair 2, Cohort Studies, Control Groups, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Glucose, Haplotypes, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Phenotype, Polymorphism, Genetic, Scandinavia",
author = "Rasmussen, {S{\o}ren K} and Urhammer, {S{\o}ren A} and Berglund, {Lars Erik} and Jensen, {Jan N} and Lars Hansen and Echwald, {S{\o}ren Morgenthaler} and Knut Borch-Johnsen and Yukio Horikawa and Hirosato Mashima and Hans Lithell and Cox, {Nancy J} and Torben Hansen and Bell, {Graeme I} and Oluf Pedersen",
year = "2002",
language = "English",
volume = "51",
pages = "3561--7",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "12",

}

RIS

TY - JOUR

T1 - Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians

AU - Rasmussen, Søren K

AU - Urhammer, Søren A

AU - Berglund, Lars Erik

AU - Jensen, Jan N

AU - Hansen, Lars

AU - Echwald, Søren Morgenthaler

AU - Borch-Johnsen, Knut

AU - Horikawa, Yukio

AU - Mashima, Hirosato

AU - Lithell, Hans

AU - Cox, Nancy J

AU - Hansen, Torben

AU - Bell, Graeme I

AU - Pedersen, Oluf

PY - 2002

Y1 - 2002

N2 - Variations in the calpain-10 gene (CAPN10) have been identified among Mexican-Americans, and an at-risk haplotype combination (112/121) defined by three polymorphisms, UCSNP-43, -19, and -63, confers increased risk of type 2 diabetes. Here we examine the three polymorphisms in 1,594 Scandinavian subjects, including 409 type 2 diabetic patients, 200 glucose-tolerant control subjects, 322 young healthy subjects, 206 glucose-tolerant offspring of diabetic patients, and 457 glucose-tolerant 70-year-old men. The frequency of the 112/121 combination was not significantly different in 409 type 2 diabetic subjects compared with 200 glucose-tolerant control subjects (0.06 vs. 0.05; odds ratio 1.32 [95% CI 0.58-3.30]). In glucose-tolerant subjects, neither the single-nucleotide polymorphisms individually nor the 112/121 combination were associated with alterations in plasma glucose, serum insulin, or serum C-peptide levels at fasting or during an oral glucose tolerance test, estimates of insulin sensitivity, or glucose-induced insulin secretion. In conclusion, the frequency of the 112/121 at-risk haplotype of CAPN10 is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and type 2 diabetes, insulin resistance, or impaired insulin secretion.

AB - Variations in the calpain-10 gene (CAPN10) have been identified among Mexican-Americans, and an at-risk haplotype combination (112/121) defined by three polymorphisms, UCSNP-43, -19, and -63, confers increased risk of type 2 diabetes. Here we examine the three polymorphisms in 1,594 Scandinavian subjects, including 409 type 2 diabetic patients, 200 glucose-tolerant control subjects, 322 young healthy subjects, 206 glucose-tolerant offspring of diabetic patients, and 457 glucose-tolerant 70-year-old men. The frequency of the 112/121 combination was not significantly different in 409 type 2 diabetic subjects compared with 200 glucose-tolerant control subjects (0.06 vs. 0.05; odds ratio 1.32 [95% CI 0.58-3.30]). In glucose-tolerant subjects, neither the single-nucleotide polymorphisms individually nor the 112/121 combination were associated with alterations in plasma glucose, serum insulin, or serum C-peptide levels at fasting or during an oral glucose tolerance test, estimates of insulin sensitivity, or glucose-induced insulin secretion. In conclusion, the frequency of the 112/121 at-risk haplotype of CAPN10 is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and type 2 diabetes, insulin resistance, or impaired insulin secretion.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Calpain

KW - Chromosomes, Human, Pair 2

KW - Cohort Studies

KW - Control Groups

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Glucose

KW - Haplotypes

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Polymorphism, Genetic

KW - Scandinavia

M3 - Journal article

C2 - 12453914

VL - 51

SP - 3561

EP - 3567

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 12

ER -

ID: 38457830