Multiligament injuries (MLI) of the knee are rare and only ca. 150 MLI reconstructions are performed per year in Denmark. This review summarises the current guidelines for work-up and treatment. Surgical treatment of MLI is centralised to five highly specialised orthopaedic departments, while all hospitals are responsible for the initial treatment and diagnostics. Injury patterns can be complex and demand thorough analysis in collaboration with a department with highly specialised function in MLI. Although a nationwide interdisciplinary approach has been implemented, patients usually do not fully return to their pre-injury activity level and have a higher risk of developing osteoarthritis.