Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa. / Hansen, Mette Reimert; Jakobsen, Tim Holm; Bang, Claus Gunnar; Cohrt, Anders Emil; Hansen, Casper Lykke; Clausen, Janie Regitse Waël; Le Quement, Sebastian Thordal; Tolker-Nielsen, Tim; Givskov, Michael; Nielsen, Thomas.

In: Bioorganic & Medicinal Chemistry, Vol. 23, No. 7, 2015, p. 1638-1650.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, MR, Jakobsen, TH, Bang, CG, Cohrt, AE, Hansen, CL, Clausen, JRW, Le Quement, ST, Tolker-Nielsen, T, Givskov, M & Nielsen, T 2015, 'Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa', Bioorganic & Medicinal Chemistry, vol. 23, no. 7, pp. 1638-1650. https://doi.org/10.1016/j.bmc.2015.01.038

APA

Hansen, M. R., Jakobsen, T. H., Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, T., Givskov, M., & Nielsen, T. (2015). Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa. Bioorganic & Medicinal Chemistry, 23(7), 1638-1650. https://doi.org/10.1016/j.bmc.2015.01.038

Vancouver

Hansen MR, Jakobsen TH, Bang CG, Cohrt AE, Hansen CL, Clausen JRW et al. Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa. Bioorganic & Medicinal Chemistry. 2015;23(7):1638-1650. https://doi.org/10.1016/j.bmc.2015.01.038

Author

Hansen, Mette Reimert ; Jakobsen, Tim Holm ; Bang, Claus Gunnar ; Cohrt, Anders Emil ; Hansen, Casper Lykke ; Clausen, Janie Regitse Waël ; Le Quement, Sebastian Thordal ; Tolker-Nielsen, Tim ; Givskov, Michael ; Nielsen, Thomas. / Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa. In: Bioorganic & Medicinal Chemistry. 2015 ; Vol. 23, No. 7. pp. 1638-1650.

Bibtex

@article{e58a804ab77f4814923428aaef251960,

title = "Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa",

abstract = "In an attempt to devise new antimicrobial treatments for biofilm infections, the bacterial cell-cell communication system termed quorum sensing has emerged as an attractive target. It has proven possible to intercept the communication system by synthetic non-native ligands and thereby lower the pathogenesis and antibiotic tolerance of a bacterial biofilm. To identify the structural elements important for antagonistic or agonistic activity against the Pseudomonas aeruginosa LasR protein, we report the synthesis and screening of new triazole-containing mimics of natural N-acyl homoserine lactones. A series of azide- and alkyne-containing homoserine lactone building blocks was used to prepare an expanded set of 123 homoserine lactone analogues through a combination of solution- and solid-phase synthesis methods. The resulting compounds were subjected to cell-based quorum sensing screening assays, thereby revealing several bioactive compounds, including 13 compounds with antagonistic activity and 9 compounds with agonistic activity.",

author = "Hansen, {Mette Reimert} and Jakobsen, {Tim Holm} and Bang, {Claus Gunnar} and Cohrt, {Anders Emil} and Hansen, {Casper Lykke} and Clausen, {Janie Regitse Wa{\"e}l} and {Le Quement}, {Sebastian Thordal} and Tim Tolker-Nielsen and Michael Givskov and Thomas Nielsen",

year = "2015",

doi = "10.1016/j.bmc.2015.01.038",

language = "English",

volume = "23",

pages = "1638--1650",

journal = "Bioorganic & Medicinal Chemistry",

issn = "0968-0896",

publisher = "Pergamon Press",

number = "7",

}

RIS

TY - JOUR

T1 - Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

AU - Hansen, Mette Reimert

AU - Jakobsen, Tim Holm

AU - Bang, Claus Gunnar

AU - Cohrt, Anders Emil

AU - Hansen, Casper Lykke

AU - Clausen, Janie Regitse Waël

AU - Le Quement, Sebastian Thordal

AU - Tolker-Nielsen, Tim

AU - Givskov, Michael

AU - Nielsen, Thomas

PY - 2015

Y1 - 2015

N2 - In an attempt to devise new antimicrobial treatments for biofilm infections, the bacterial cell-cell communication system termed quorum sensing has emerged as an attractive target. It has proven possible to intercept the communication system by synthetic non-native ligands and thereby lower the pathogenesis and antibiotic tolerance of a bacterial biofilm. To identify the structural elements important for antagonistic or agonistic activity against the Pseudomonas aeruginosa LasR protein, we report the synthesis and screening of new triazole-containing mimics of natural N-acyl homoserine lactones. A series of azide- and alkyne-containing homoserine lactone building blocks was used to prepare an expanded set of 123 homoserine lactone analogues through a combination of solution- and solid-phase synthesis methods. The resulting compounds were subjected to cell-based quorum sensing screening assays, thereby revealing several bioactive compounds, including 13 compounds with antagonistic activity and 9 compounds with agonistic activity.

AB - In an attempt to devise new antimicrobial treatments for biofilm infections, the bacterial cell-cell communication system termed quorum sensing has emerged as an attractive target. It has proven possible to intercept the communication system by synthetic non-native ligands and thereby lower the pathogenesis and antibiotic tolerance of a bacterial biofilm. To identify the structural elements important for antagonistic or agonistic activity against the Pseudomonas aeruginosa LasR protein, we report the synthesis and screening of new triazole-containing mimics of natural N-acyl homoserine lactones. A series of azide- and alkyne-containing homoserine lactone building blocks was used to prepare an expanded set of 123 homoserine lactone analogues through a combination of solution- and solid-phase synthesis methods. The resulting compounds were subjected to cell-based quorum sensing screening assays, thereby revealing several bioactive compounds, including 13 compounds with antagonistic activity and 9 compounds with agonistic activity.

U2 - 10.1016/j.bmc.2015.01.038

DO - 10.1016/j.bmc.2015.01.038

M3 - Journal article

C2 - 25716005

VL - 23

SP - 1638

EP - 1650

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 7

ER -

ID: 135482604