Treatment-resistant depression and labor market affiliation in the Danish welfare society: a register-based study
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Treatment-resistant depression and labor market affiliation in the Danish welfare society : a register-based study. / Gronemann, Frederikke Hordam; Lund, Thomas; Lindholdt, Louise; Madsen, Kathrine Bang; Jørgensen, Martin Balslev; Nordentoft, Merete; Osler, Merete.
In: Social Psychiatry and Psychiatric Epidemiology, Vol. 57, 2022, p. 1189–1199.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Treatment-resistant depression and labor market affiliation in the Danish welfare society
T2 - a register-based study
AU - Gronemann, Frederikke Hordam
AU - Lund, Thomas
AU - Lindholdt, Louise
AU - Madsen, Kathrine Bang
AU - Jørgensen, Martin Balslev
AU - Nordentoft, Merete
AU - Osler, Merete
PY - 2022
Y1 - 2022
N2 - Purpose We explored if patients with treatment-resistant depression (TRD) go through different states of labor market affiliation during their course of illness before they return to work or obtain early retirement as compared to patients without TRD. Methods All adults between 18 and 58 years with a first-time hospital contact due to depression in Danish patients' registers from 2000 to 2014 were followed in a nationwide labor market database. At time of TRD (index week), TRD patients were matched with patients without TRD in a 1:2 ratio. Sequence analysis and logistic regression were applied to explore the association of TRD and labor market affiliation and measures of transitions between labor market states 52 weeks before and after the index week. Results At the index week, 14.1% of patients with TRD were in employment, whereas the proportion was 26.4% among non-TRD patients. Over time, the proportion of patients in employment increased slightly to 25.5% for TRD and 33.7% for non-TRD patients. The proportion of TRD patients with sickness absence at index was 47.0%, while the proportion was 26.2% for non-TRD patients. The adjusted odds of a below mean volatility of labor market transitions, characterized by more episodes in passive social transfer payments and disability pension, were higher among patients with TRD compared with non-TRD patients (OR 1.63, 95% CI [1.56-1.69]). Similarly, the adjusted odds of a below mean integration into employment were 1.63 higher among TRD patients compared with non-TRD patients (95% CI [1.56-1.70]). Conclusion Patients with TRD have higher levels of sickness absence and lower levels of reintegration into the labor market after meeting the criteria for TRD compared with patients without TRD.
AB - Purpose We explored if patients with treatment-resistant depression (TRD) go through different states of labor market affiliation during their course of illness before they return to work or obtain early retirement as compared to patients without TRD. Methods All adults between 18 and 58 years with a first-time hospital contact due to depression in Danish patients' registers from 2000 to 2014 were followed in a nationwide labor market database. At time of TRD (index week), TRD patients were matched with patients without TRD in a 1:2 ratio. Sequence analysis and logistic regression were applied to explore the association of TRD and labor market affiliation and measures of transitions between labor market states 52 weeks before and after the index week. Results At the index week, 14.1% of patients with TRD were in employment, whereas the proportion was 26.4% among non-TRD patients. Over time, the proportion of patients in employment increased slightly to 25.5% for TRD and 33.7% for non-TRD patients. The proportion of TRD patients with sickness absence at index was 47.0%, while the proportion was 26.2% for non-TRD patients. The adjusted odds of a below mean volatility of labor market transitions, characterized by more episodes in passive social transfer payments and disability pension, were higher among patients with TRD compared with non-TRD patients (OR 1.63, 95% CI [1.56-1.69]). Similarly, the adjusted odds of a below mean integration into employment were 1.63 higher among TRD patients compared with non-TRD patients (95% CI [1.56-1.70]). Conclusion Patients with TRD have higher levels of sickness absence and lower levels of reintegration into the labor market after meeting the criteria for TRD compared with patients without TRD.
KW - Treatment-resistant depression
KW - Antidepressants
KW - Labor market affiliation
KW - Register-based study
KW - DISABILITY PENSION
KW - SICKNESS ABSENCE
KW - FOLLOW-UP
U2 - 10.1007/s00127-022-02243-9
DO - 10.1007/s00127-022-02243-9
M3 - Journal article
C2 - 35133445
VL - 57
SP - 1189
EP - 1199
JO - Social Psychiatry and Psychiatric Epidemiology
JF - Social Psychiatry and Psychiatric Epidemiology
SN - 0933-7954
ER -
ID: 297360116