Transposable elements in cancer as a by-product of stress-induced evolvability

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Transposable elements in cancer as a by-product of stress-induced evolvability. / Mourier, Tobias; Nielsen, Lars P.; Hansen, Anders Johannes; Willerslev, Eske.

In: Frontiers in Genetics, Vol. 5, 156, 2014.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mourier, T, Nielsen, LP, Hansen, AJ & Willerslev, E 2014, 'Transposable elements in cancer as a by-product of stress-induced evolvability', Frontiers in Genetics, vol. 5, 156. https://doi.org/10.3389/fgene.2014.00156

APA

Mourier, T., Nielsen, L. P., Hansen, A. J., & Willerslev, E. (2014). Transposable elements in cancer as a by-product of stress-induced evolvability. Frontiers in Genetics, 5, [156]. https://doi.org/10.3389/fgene.2014.00156

Vancouver

Mourier T, Nielsen LP, Hansen AJ, Willerslev E. Transposable elements in cancer as a by-product of stress-induced evolvability. Frontiers in Genetics. 2014;5. 156. https://doi.org/10.3389/fgene.2014.00156

Author

Mourier, Tobias ; Nielsen, Lars P. ; Hansen, Anders Johannes ; Willerslev, Eske. / Transposable elements in cancer as a by-product of stress-induced evolvability. In: Frontiers in Genetics. 2014 ; Vol. 5.

Bibtex

@article{d4f93e78eb664a238903319ee2de66b0,
title = "Transposable elements in cancer as a by-product of stress-induced evolvability",
abstract = "Transposable elements (TEs) are ubiquitous in eukaryotic genomes. Barbara McClintock's famous notion of TEs acting as controlling elements modifying the genetic response of an organism upon exposure to stressful environments has since been solidly supported in a series of model organisms. This requires the TE activity response to possess an element of specificity and be targeted toward certain parts of the genome. We propose that a similar TE response is present in human cells, and that this stress response may drive the onset of human cancers. As such, TE-driven cancers may be viewed as an evolutionary by-product of organisms' abilities to genetically adapt to environmental stress.",
author = "Tobias Mourier and Nielsen, {Lars P.} and Hansen, {Anders Johannes} and Eske Willerslev",
year = "2014",
doi = "10.3389/fgene.2014.00156",
language = "English",
volume = "5",
journal = "Frontiers in Genetics",
issn = "1664-8021",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Transposable elements in cancer as a by-product of stress-induced evolvability

AU - Mourier, Tobias

AU - Nielsen, Lars P.

AU - Hansen, Anders Johannes

AU - Willerslev, Eske

PY - 2014

Y1 - 2014

N2 - Transposable elements (TEs) are ubiquitous in eukaryotic genomes. Barbara McClintock's famous notion of TEs acting as controlling elements modifying the genetic response of an organism upon exposure to stressful environments has since been solidly supported in a series of model organisms. This requires the TE activity response to possess an element of specificity and be targeted toward certain parts of the genome. We propose that a similar TE response is present in human cells, and that this stress response may drive the onset of human cancers. As such, TE-driven cancers may be viewed as an evolutionary by-product of organisms' abilities to genetically adapt to environmental stress.

AB - Transposable elements (TEs) are ubiquitous in eukaryotic genomes. Barbara McClintock's famous notion of TEs acting as controlling elements modifying the genetic response of an organism upon exposure to stressful environments has since been solidly supported in a series of model organisms. This requires the TE activity response to possess an element of specificity and be targeted toward certain parts of the genome. We propose that a similar TE response is present in human cells, and that this stress response may drive the onset of human cancers. As such, TE-driven cancers may be viewed as an evolutionary by-product of organisms' abilities to genetically adapt to environmental stress.

U2 - 10.3389/fgene.2014.00156

DO - 10.3389/fgene.2014.00156

M3 - Journal article

C2 - 24910642

VL - 5

JO - Frontiers in Genetics

JF - Frontiers in Genetics

SN - 1664-8021

M1 - 156

ER -

ID: 124559053