Translational control through ribosome heterogeneity and functional specialization

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Translational control through ribosome heterogeneity and functional specialization. / Gay, David M.; Lund, Anders H.; Jansson, Martin D.

In: Trends in Biochemical Sciences, Vol. 47, No. 1, 2022, p. 66-81.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Gay, DM, Lund, AH & Jansson, MD 2022, 'Translational control through ribosome heterogeneity and functional specialization', Trends in Biochemical Sciences, vol. 47, no. 1, pp. 66-81. https://doi.org/10.1016/j.tibs.2021.07.001

APA

Gay, D. M., Lund, A. H., & Jansson, M. D. (2022). Translational control through ribosome heterogeneity and functional specialization. Trends in Biochemical Sciences, 47(1), 66-81. https://doi.org/10.1016/j.tibs.2021.07.001

Vancouver

Gay DM, Lund AH, Jansson MD. Translational control through ribosome heterogeneity and functional specialization. Trends in Biochemical Sciences. 2022;47(1):66-81. https://doi.org/10.1016/j.tibs.2021.07.001

Author

Gay, David M. ; Lund, Anders H. ; Jansson, Martin D. / Translational control through ribosome heterogeneity and functional specialization. In: Trends in Biochemical Sciences. 2022 ; Vol. 47, No. 1. pp. 66-81.

Bibtex

@article{cd6a61af6e3643579a28045bb1436f05,
title = "Translational control through ribosome heterogeneity and functional specialization",
abstract = "Over the past decade, it has become increasingly apparent that ribosomes are significantly more heterogeneous than originally thought, with variation emanating from both the rRNA and protein content of ribosomes.This heterogeneity can potentially confer functional ribosome specialization, contributing to translational control, thereby identifying the ribosome as a key regulatory player in translation.Studies have uncovered interindividual and intertissue variant rRNA alleles and there has also been a recent focus on identifying functional roles for the previously enigmatic eukaryotic rRNA expansion segments.Technological advances have permitted accurate, quantitative analysis of rRNA modifications across several organisms, with functionality ascribed to certain rRNA modifications.Other work has centered on identifying specialization arising due to changes in ribosome protein composition.",
author = "Gay, {David M.} and Lund, {Anders H.} and Jansson, {Martin D.}",
year = "2022",
doi = "10.1016/j.tibs.2021.07.001",
language = "English",
volume = "47",
pages = "66--81",
journal = "Trends in Biochemical Sciences",
issn = "0968-0004",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Translational control through ribosome heterogeneity and functional specialization

AU - Gay, David M.

AU - Lund, Anders H.

AU - Jansson, Martin D.

PY - 2022

Y1 - 2022

N2 - Over the past decade, it has become increasingly apparent that ribosomes are significantly more heterogeneous than originally thought, with variation emanating from both the rRNA and protein content of ribosomes.This heterogeneity can potentially confer functional ribosome specialization, contributing to translational control, thereby identifying the ribosome as a key regulatory player in translation.Studies have uncovered interindividual and intertissue variant rRNA alleles and there has also been a recent focus on identifying functional roles for the previously enigmatic eukaryotic rRNA expansion segments.Technological advances have permitted accurate, quantitative analysis of rRNA modifications across several organisms, with functionality ascribed to certain rRNA modifications.Other work has centered on identifying specialization arising due to changes in ribosome protein composition.

AB - Over the past decade, it has become increasingly apparent that ribosomes are significantly more heterogeneous than originally thought, with variation emanating from both the rRNA and protein content of ribosomes.This heterogeneity can potentially confer functional ribosome specialization, contributing to translational control, thereby identifying the ribosome as a key regulatory player in translation.Studies have uncovered interindividual and intertissue variant rRNA alleles and there has also been a recent focus on identifying functional roles for the previously enigmatic eukaryotic rRNA expansion segments.Technological advances have permitted accurate, quantitative analysis of rRNA modifications across several organisms, with functionality ascribed to certain rRNA modifications.Other work has centered on identifying specialization arising due to changes in ribosome protein composition.

U2 - 10.1016/j.tibs.2021.07.001

DO - 10.1016/j.tibs.2021.07.001

M3 - Review

C2 - 34312084

VL - 47

SP - 66

EP - 81

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 1

ER -

ID: 274968128