Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B : In vitro assessment and cytocompatibility studies. / Kontogiannidou, Eleni; Meikopoulos, Thomas; Virgiliou, Christina; Bouropoulos, Nikolaos; Gika, Helen; Vizirianakis, Ioannis S.; Mullertz, Anette; Fatouros, Dimitrios G.

In: Journal of Drug Delivery Science and Technology, Vol. 56, 101524, 04.2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kontogiannidou, E, Meikopoulos, T, Virgiliou, C, Bouropoulos, N, Gika, H, Vizirianakis, IS, Mullertz, A & Fatouros, DG 2020, 'Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies', Journal of Drug Delivery Science and Technology, vol. 56, 101524. https://doi.org/10.1016/j.jddst.2020.101524

APA

Kontogiannidou, E., Meikopoulos, T., Virgiliou, C., Bouropoulos, N., Gika, H., Vizirianakis, I. S., Mullertz, A., & Fatouros, D. G. (2020). Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies. Journal of Drug Delivery Science and Technology, 56, [101524]. https://doi.org/10.1016/j.jddst.2020.101524

Vancouver

Kontogiannidou E, Meikopoulos T, Virgiliou C, Bouropoulos N, Gika H, Vizirianakis IS et al. Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies. Journal of Drug Delivery Science and Technology. 2020 Apr;56. 101524. https://doi.org/10.1016/j.jddst.2020.101524

Author

Kontogiannidou, Eleni ; Meikopoulos, Thomas ; Virgiliou, Christina ; Bouropoulos, Nikolaos ; Gika, Helen ; Vizirianakis, Ioannis S. ; Mullertz, Anette ; Fatouros, Dimitrios G. / Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B : In vitro assessment and cytocompatibility studies. In: Journal of Drug Delivery Science and Technology. 2020 ; Vol. 56.

Bibtex

@article{37a4d2f9ec6e4fe994c6ab406a5d6d22,
title = "Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies",
abstract = "In the current study, a self-nanoemulsifying drug delivery system (SNEDDS) containing N-trimethyl chitosan chloride (TMC) was developed and evaluated for its potential to deliver amphotericin B (AmpB) via the gastrointestinal tract. SNEDDS comprising Captex 355, Kolliphor RH40 and Propylene Glycol were optimized and characterized for their formation spontaneity, droplet size and drug loading. Investigations on the effects of the application SNEDDS containing TMC to a model intestinal epithelium (Caco-2 monolayer) indicated the capability of the formulations to induce the transient opening of tight junctions. Caco-2 cell viability studies confirmed the safety of the SNEDDS, whereas in vitro transport studies of AmpB through Caco-2 cell monolayers showed the permeation enhancing ability of TMC. Our results suggest that chitosan derivative TMC combined with a SNEDDS may be used as permeation enhancer to facilitate oral delivery of AmpB.",
keywords = "Trimethyl chitosan, Self-emulsifying drug delivery systems, Amphotericin B, Oral drug delivery, Caco-2 cells, MUCOADHESIVE PROPERTIES, VISCERAL LEISHMANIASIS, INTESTINAL-ABSORPTION, FORMULATION, QUATERNIZATION, NANOPARTICLES, TRANSPORT, CHLORIDE, INSULIN, BIODISTRIBUTION",
author = "Eleni Kontogiannidou and Thomas Meikopoulos and Christina Virgiliou and Nikolaos Bouropoulos and Helen Gika and Vizirianakis, {Ioannis S.} and Anette Mullertz and Fatouros, {Dimitrios G.}",
year = "2020",
month = apr,
doi = "10.1016/j.jddst.2020.101524",
language = "English",
volume = "56",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B

T2 - In vitro assessment and cytocompatibility studies

AU - Kontogiannidou, Eleni

AU - Meikopoulos, Thomas

AU - Virgiliou, Christina

AU - Bouropoulos, Nikolaos

AU - Gika, Helen

AU - Vizirianakis, Ioannis S.

AU - Mullertz, Anette

AU - Fatouros, Dimitrios G.

PY - 2020/4

Y1 - 2020/4

N2 - In the current study, a self-nanoemulsifying drug delivery system (SNEDDS) containing N-trimethyl chitosan chloride (TMC) was developed and evaluated for its potential to deliver amphotericin B (AmpB) via the gastrointestinal tract. SNEDDS comprising Captex 355, Kolliphor RH40 and Propylene Glycol were optimized and characterized for their formation spontaneity, droplet size and drug loading. Investigations on the effects of the application SNEDDS containing TMC to a model intestinal epithelium (Caco-2 monolayer) indicated the capability of the formulations to induce the transient opening of tight junctions. Caco-2 cell viability studies confirmed the safety of the SNEDDS, whereas in vitro transport studies of AmpB through Caco-2 cell monolayers showed the permeation enhancing ability of TMC. Our results suggest that chitosan derivative TMC combined with a SNEDDS may be used as permeation enhancer to facilitate oral delivery of AmpB.

AB - In the current study, a self-nanoemulsifying drug delivery system (SNEDDS) containing N-trimethyl chitosan chloride (TMC) was developed and evaluated for its potential to deliver amphotericin B (AmpB) via the gastrointestinal tract. SNEDDS comprising Captex 355, Kolliphor RH40 and Propylene Glycol were optimized and characterized for their formation spontaneity, droplet size and drug loading. Investigations on the effects of the application SNEDDS containing TMC to a model intestinal epithelium (Caco-2 monolayer) indicated the capability of the formulations to induce the transient opening of tight junctions. Caco-2 cell viability studies confirmed the safety of the SNEDDS, whereas in vitro transport studies of AmpB through Caco-2 cell monolayers showed the permeation enhancing ability of TMC. Our results suggest that chitosan derivative TMC combined with a SNEDDS may be used as permeation enhancer to facilitate oral delivery of AmpB.

KW - Trimethyl chitosan

KW - Self-emulsifying drug delivery systems

KW - Amphotericin B

KW - Oral drug delivery

KW - Caco-2 cells

KW - MUCOADHESIVE PROPERTIES

KW - VISCERAL LEISHMANIASIS

KW - INTESTINAL-ABSORPTION

KW - FORMULATION

KW - QUATERNIZATION

KW - NANOPARTICLES

KW - TRANSPORT

KW - CHLORIDE

KW - INSULIN

KW - BIODISTRIBUTION

U2 - 10.1016/j.jddst.2020.101524

DO - 10.1016/j.jddst.2020.101524

M3 - Journal article

VL - 56

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

M1 - 101524

ER -

ID: 246352419