Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage

Research output: Contribution to journal › Journal article › Research › peer-review

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Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage. / Skovgaard, T; Rasmussen, Lene Juel; Munch-Petersen, Birgitte.

In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 29, No. 4-6, 2010, p. 347-51.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Skovgaard, T, Rasmussen, LJ & Munch-Petersen, B 2010, 'Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage', Nucleosides, Nucleotides and Nucleic Acids, vol. 29, no. 4-6, pp. 347-51. https://doi.org/10.1080/15257771003741091

APA

Skovgaard, T., Rasmussen, L. J., & Munch-Petersen, B. (2010). Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage. Nucleosides, Nucleotides and Nucleic Acids, 29(4-6), 347-51. https://doi.org/10.1080/15257771003741091

Vancouver

Skovgaard T, Rasmussen LJ, Munch-Petersen B. Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage. Nucleosides, Nucleotides and Nucleic Acids. 2010;29(4-6):347-51. https://doi.org/10.1080/15257771003741091

Author

Skovgaard, T ; Rasmussen, Lene Juel ; Munch-Petersen, Birgitte. / Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage. In: Nucleosides, Nucleotides and Nucleic Acids. 2010 ; Vol. 29, No. 4-6. pp. 347-51.

Bibtex

@article{125cab90b4ce11df825b000ea68e967b,
title = "Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage",
abstract = "Balanced deoxynucleotide pools are known to be important for correct DNA repair, and deficiency for some of the central enzymes in deoxynucleotide metabolism can cause imbalanced pools, which in turn can lead to mutagenesis and cell death. Here we show that cells deficient for the thymidine salvage enzyme thymidine kinase 1 (TK1) are more resistant to UV-induced DNA damage than TK1 positive cells although they have thymidine triphosphate (dTTP) levels of only half the size of control cells. Our results suggest that higher thymidine levels in the TK- cells caused by defect thymidine salvage to dTTP protects against UV irradiation.",
author = "T Skovgaard and Rasmussen, {Lene Juel} and Birgitte Munch-Petersen",
year = "2010",
doi = "10.1080/15257771003741091",
language = "English",
volume = "29",
pages = "347--51",
journal = "Nucleosides, Nucleotides and Nucleic Acids",
issn = "1525-7770",
publisher = "Taylor & Francis",
number = "4-6",

}

RIS

TY - JOUR

T1 - Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage

AU - Skovgaard, T

AU - Rasmussen, Lene Juel

AU - Munch-Petersen, Birgitte

PY - 2010

Y1 - 2010

N2 - Balanced deoxynucleotide pools are known to be important for correct DNA repair, and deficiency for some of the central enzymes in deoxynucleotide metabolism can cause imbalanced pools, which in turn can lead to mutagenesis and cell death. Here we show that cells deficient for the thymidine salvage enzyme thymidine kinase 1 (TK1) are more resistant to UV-induced DNA damage than TK1 positive cells although they have thymidine triphosphate (dTTP) levels of only half the size of control cells. Our results suggest that higher thymidine levels in the TK- cells caused by defect thymidine salvage to dTTP protects against UV irradiation.

AB - Balanced deoxynucleotide pools are known to be important for correct DNA repair, and deficiency for some of the central enzymes in deoxynucleotide metabolism can cause imbalanced pools, which in turn can lead to mutagenesis and cell death. Here we show that cells deficient for the thymidine salvage enzyme thymidine kinase 1 (TK1) are more resistant to UV-induced DNA damage than TK1 positive cells although they have thymidine triphosphate (dTTP) levels of only half the size of control cells. Our results suggest that higher thymidine levels in the TK- cells caused by defect thymidine salvage to dTTP protects against UV irradiation.

U2 - 10.1080/15257771003741091

DO - 10.1080/15257771003741091

M3 - Journal article

C2 - 20544518

VL - 29

SP - 347

EP - 351

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

SN - 1525-7770

IS - 4-6

ER -

ID: 21692675