A new Pb-II coordination complex [PbL(OAc)], which was readily synthesized from a mixture of Pb(OAc)(2)center dot 3H(2)O and 1-(pyridin-2-yl)benzylidene-4-phenyl-thiosemicarbazide (HL) is reported. The crystal structure analysis of [PbL(OAc)] showed that the Pb-II cation is N,N',S-chelated by the tridentate pincer-type ligand L and by the oxygen atoms of the acetate anion. In addition, the metal centre forms Pb center dot center dot center dot O and Pb center dot center dot center dot S tetrel bonds with an adjacent complex molecule, yielding a 1D zigzag polymeric chain, which is reinforced by N-H center dot center dot center dot O hydrogen bonds and pi center dot center dot center dot pi interactions. These chains are interlinked by C-H center dot center dot center dot py non-covalent interactions, realized between one of the acetate hydrogen atoms and the pyridine rings. According to the Hirshfeld surface analysis, the crystal packing is mainly characterized by intermolecular H center dot center dot center dot H, H center dot center dot center dot C and H center dot center dot center dot O contacts, followed by H center dot center dot center dot N, H center dot center dot center dot S, C center dot center dot center dot C, C center dot center dot center dot N, Pb center dot center dot center dot H, Pb center dot center dot center dot O and Pb center dot center dot center dot S contacts. The FTIR and H-1 NMR spectra of [PbL(OAc)] testify to the deprotonation of the parent ligand HL, while the acetate ligand exhibits an anisobidentate coordination mode as established by means of single-crystal X-ray diffraction and FTIR spectroscopy. Lastly, theoretical calculations at the PBEO-D3/def2-TZVP level of theory have been used to analyze and characterize the Pb center dot center dot center dot O and Pb center dot center dot center dot S tetrel bonds observed in the crystal of [PbL(OAc)], using a combination of QTAIM (Quantum Theory of Atoms in Molecules) and NCIPlot (Non-Covalent Interaction Plot) computational tools.