The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles. / García-Díaz, María; Birch, Ditlev; Wan, Feng; Nielsen, Hanne Mørck.

In: Advanced Drug Delivery Reviews, Vol. 124, 01.2018, p. 107-124.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

García-Díaz, M, Birch, D, Wan, F & Nielsen, HM 2018, 'The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles', Advanced Drug Delivery Reviews, vol. 124, pp. 107-124. https://doi.org/10.1016/j.addr.2017.11.002

APA

García-Díaz, M., Birch, D., Wan, F., & Nielsen, H. M. (2018). The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles. Advanced Drug Delivery Reviews, 124, 107-124. https://doi.org/10.1016/j.addr.2017.11.002

Vancouver

García-Díaz M, Birch D, Wan F, Nielsen HM. The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles. Advanced Drug Delivery Reviews. 2018 Jan;124:107-124. https://doi.org/10.1016/j.addr.2017.11.002

Author

García-Díaz, María ; Birch, Ditlev ; Wan, Feng ; Nielsen, Hanne Mørck. / The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles. In: Advanced Drug Delivery Reviews. 2018 ; Vol. 124. pp. 107-124.

Bibtex

@article{100d792065bd41d19c4735c22cb3763b,

title = "The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles",

abstract = "Mucosal administration of drugs and drug delivery systems has gained increasing interest. However, nanoparticles intended to protect and deliver drugs to epithelial surfaces require transport through the surface-lining mucus. Translation from bench to bedside is particularly challenging for mucosal administration since a variety of parameters will influence the specific barrier properties of the mucus including the luminal fluids, the microbiota, the mucus composition and clearance rate, and the condition of the underlying epithelia. Besides, after administration, nanoparticles interact with the mucosal components, forming a biomolecular corona that modulates their behavior and fate after mucosal administration. These interactions are greatly influenced by the nanoparticle properties and therefore different designs and surface-engineering strategies have been proposed. Overall, it is essential to evaluate these biomolecule-nanoparticle interactions by complementary techniques using complex and relevant mucus barrier matrices.",

keywords = "Journal Article",

author = "Mar{\'i}a Garc{\'i}a-D{\'i}az and Ditlev Birch and Feng Wan and Nielsen, {Hanne M{\o}rck}",

note = "Copyright {\textcopyright} 2017. Published by Elsevier B.V.",

year = "2018",

month = jan,

doi = "10.1016/j.addr.2017.11.002",

language = "English",

volume = "124",

pages = "107--124",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles

AU - García-Díaz, María

AU - Birch, Ditlev

AU - Wan, Feng

AU - Nielsen, Hanne Mørck

PY - 2018/1

Y1 - 2018/1

N2 - Mucosal administration of drugs and drug delivery systems has gained increasing interest. However, nanoparticles intended to protect and deliver drugs to epithelial surfaces require transport through the surface-lining mucus. Translation from bench to bedside is particularly challenging for mucosal administration since a variety of parameters will influence the specific barrier properties of the mucus including the luminal fluids, the microbiota, the mucus composition and clearance rate, and the condition of the underlying epithelia. Besides, after administration, nanoparticles interact with the mucosal components, forming a biomolecular corona that modulates their behavior and fate after mucosal administration. These interactions are greatly influenced by the nanoparticle properties and therefore different designs and surface-engineering strategies have been proposed. Overall, it is essential to evaluate these biomolecule-nanoparticle interactions by complementary techniques using complex and relevant mucus barrier matrices.

AB - Mucosal administration of drugs and drug delivery systems has gained increasing interest. However, nanoparticles intended to protect and deliver drugs to epithelial surfaces require transport through the surface-lining mucus. Translation from bench to bedside is particularly challenging for mucosal administration since a variety of parameters will influence the specific barrier properties of the mucus including the luminal fluids, the microbiota, the mucus composition and clearance rate, and the condition of the underlying epithelia. Besides, after administration, nanoparticles interact with the mucosal components, forming a biomolecular corona that modulates their behavior and fate after mucosal administration. These interactions are greatly influenced by the nanoparticle properties and therefore different designs and surface-engineering strategies have been proposed. Overall, it is essential to evaluate these biomolecule-nanoparticle interactions by complementary techniques using complex and relevant mucus barrier matrices.

KW - Journal Article

U2 - 10.1016/j.addr.2017.11.002

DO - 10.1016/j.addr.2017.11.002

M3 - Journal article

C2 - 29117511

VL - 124

SP - 107

EP - 124

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

ER -

ID: 185718063