The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. / Fajas, Lluis; Egler, Viviane; Reiter, Raphael; Hansen, Jacob; Kristiansen, Karsten; Debril, Marie-Bernard; Miard, Stéphanie; Auwerx, Johan.

In: Developmental Cell, Vol. 3, No. 6, 2002, p. 903-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fajas, L, Egler, V, Reiter, R, Hansen, J, Kristiansen, K, Debril, M-B, Miard, S & Auwerx, J 2002, 'The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation', Developmental Cell, vol. 3, no. 6, pp. 903-10.

APA

Fajas, L., Egler, V., Reiter, R., Hansen, J., Kristiansen, K., Debril, M-B., Miard, S., & Auwerx, J. (2002). The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Developmental Cell, 3(6), 903-10.

Vancouver

Fajas L, Egler V, Reiter R, Hansen J, Kristiansen K, Debril M-B et al. The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Developmental Cell. 2002;3(6):903-10.

Author

Fajas, Lluis ; Egler, Viviane ; Reiter, Raphael ; Hansen, Jacob ; Kristiansen, Karsten ; Debril, Marie-Bernard ; Miard, Stéphanie ; Auwerx, Johan. / The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. In: Developmental Cell. 2002 ; Vol. 3, No. 6. pp. 903-10.

Bibtex

@article{346283d05c1e11df928f000ea68e967b,
title = "The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation",
abstract = "The retinoblastoma protein (RB) has previously been shown to facilitate adipocyte differentiation by inducing cell cycle arrest and enhancing the transactivation by the adipogenic CCAAT/enhancer binding proteins (C/EBP). We show here that the peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor pivotal for adipogenesis, promotes adipocyte differentiation more efficiently in the absence of RB. PPARgamma and RB were shown to coimmunoprecipitate, and this PPARgamma-RB complex also contains the histone deacetylase HDAC3, thereby attenuating PPARgamma's capacity to drive gene expression and adipocyte differentiation. Dissociation of the PPARgamma-RB-HDAC3 complex by RB phosphorylation or by inhibition of HDAC activity stimulates adipocyte differentiation. These observations underscore an important function of both RB and HDAC3 in fine-tuning PPARgamma activity and adipocyte differentiation.",
author = "Lluis Fajas and Viviane Egler and Raphael Reiter and Jacob Hansen and Karsten Kristiansen and Marie-Bernard Debril and St{\'e}phanie Miard and Johan Auwerx",
note = "Keywords: 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Gene Expression Regulation, Enzymologic; Genes, Reporter; Histone Deacetylases; Lipoprotein Lipase; Macromolecular Substances; Mice; Phosphorylation; Protein Binding; Protein Structure, Tertiary; RNA, Messenger; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Retinoblastoma Protein; Signal Transduction; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors",
year = "2002",
language = "English",
volume = "3",
pages = "903--10",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation

AU - Fajas, Lluis

AU - Egler, Viviane

AU - Reiter, Raphael

AU - Hansen, Jacob

AU - Kristiansen, Karsten

AU - Debril, Marie-Bernard

AU - Miard, Stéphanie

AU - Auwerx, Johan

N1 - Keywords: 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Gene Expression Regulation, Enzymologic; Genes, Reporter; Histone Deacetylases; Lipoprotein Lipase; Macromolecular Substances; Mice; Phosphorylation; Protein Binding; Protein Structure, Tertiary; RNA, Messenger; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Retinoblastoma Protein; Signal Transduction; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors

PY - 2002

Y1 - 2002

N2 - The retinoblastoma protein (RB) has previously been shown to facilitate adipocyte differentiation by inducing cell cycle arrest and enhancing the transactivation by the adipogenic CCAAT/enhancer binding proteins (C/EBP). We show here that the peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor pivotal for adipogenesis, promotes adipocyte differentiation more efficiently in the absence of RB. PPARgamma and RB were shown to coimmunoprecipitate, and this PPARgamma-RB complex also contains the histone deacetylase HDAC3, thereby attenuating PPARgamma's capacity to drive gene expression and adipocyte differentiation. Dissociation of the PPARgamma-RB-HDAC3 complex by RB phosphorylation or by inhibition of HDAC activity stimulates adipocyte differentiation. These observations underscore an important function of both RB and HDAC3 in fine-tuning PPARgamma activity and adipocyte differentiation.

AB - The retinoblastoma protein (RB) has previously been shown to facilitate adipocyte differentiation by inducing cell cycle arrest and enhancing the transactivation by the adipogenic CCAAT/enhancer binding proteins (C/EBP). We show here that the peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor pivotal for adipogenesis, promotes adipocyte differentiation more efficiently in the absence of RB. PPARgamma and RB were shown to coimmunoprecipitate, and this PPARgamma-RB complex also contains the histone deacetylase HDAC3, thereby attenuating PPARgamma's capacity to drive gene expression and adipocyte differentiation. Dissociation of the PPARgamma-RB-HDAC3 complex by RB phosphorylation or by inhibition of HDAC activity stimulates adipocyte differentiation. These observations underscore an important function of both RB and HDAC3 in fine-tuning PPARgamma activity and adipocyte differentiation.

M3 - Journal article

C2 - 12479814

VL - 3

SP - 903

EP - 910

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 6

ER -

ID: 19664081