The newcomer in the integrin family: Integrin α9 in biology and cancer.

Research output: Contribution to journal › Review › Research › peer-review

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The newcomer in the integrin family: Integrin α9 in biology and cancer. / Høye, Anette Melissa; Couchman, John Robert; Wewer, Ulla M.; Yoneda, Atsuko; Fukami, Kiyoko.

In: Advances in Biological Regulation, Vol. 52, No. 2, 05.2012, p. 326-339.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Høye, AM, Couchman, JR, Wewer, UM, Yoneda, A & Fukami, K 2012, 'The newcomer in the integrin family: Integrin α9 in biology and cancer.', Advances in Biological Regulation, vol. 52, no. 2, pp. 326-339. https://doi.org/10.1016/j.jbior.2012.03.004

APA

Høye, A. M., Couchman, J. R., Wewer, U. M., Yoneda, A., & Fukami, K. (2012). The newcomer in the integrin family: Integrin α9 in biology and cancer. Advances in Biological Regulation, 52(2), 326-339. https://doi.org/10.1016/j.jbior.2012.03.004

Vancouver

Høye AM, Couchman JR, Wewer UM, Yoneda A, Fukami K. The newcomer in the integrin family: Integrin α9 in biology and cancer. Advances in Biological Regulation. 2012 May;52(2):326-339. https://doi.org/10.1016/j.jbior.2012.03.004

Author

Høye, Anette Melissa ; Couchman, John Robert ; Wewer, Ulla M. ; Yoneda, Atsuko ; Fukami, Kiyoko. / The newcomer in the integrin family: Integrin α9 in biology and cancer. In: Advances in Biological Regulation. 2012 ; Vol. 52, No. 2. pp. 326-339.

Bibtex

@article{a8e6ca6e6ba84a1c8267c4271a02cb10,
title = "The newcomer in the integrin family: Integrin α9 in biology and cancer.",
abstract = "Integrins are heterodimeric transmembrane receptors regulating cell-cell and cell-extracellular matrix interactions. Of the 24 integrin heterodimers identified in humans, a9{\ss}1 integrin is one of the least studied. a9, together with a4, comprise a more recent evolutionary sub-family of integrins that is only found in vertebrates. Since a9 was thought to have similar functions as a4, due to many shared ligands, it was a rather overlooked integrin until recently, when its importance for survival after birth was highlighted upon investigation of the a9 knockout mouse. a9{\ss}1 is expressed on a wide variety of cell types, interacts with many ligands for example fibronectin, tenascin-C and ADAM12, and has been shown to have important functions in processes such as cell adhesion and migration, lung development, lymphatic and venous valve development, and in wound healing. This has sparked an interest to investigate a9{\ss}1-mediated signaling and its regulation. This review gives an overview of the recent progress in a9{\ss}1-mediated biological and pathological processes, and discusses its potential as a target for cancer diagnosis and therapy.",
author = "H{\o}ye, {Anette Melissa} and Couchman, {John Robert} and Wewer, {Ulla M.} and Atsuko Yoneda and Kiyoko Fukami",
year = "2012",
month = may,
doi = "10.1016/j.jbior.2012.03.004",
language = "English",
volume = "52",
pages = "326--339",
journal = "Advances in Biological Regulation",
issn = "2212-4926",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - The newcomer in the integrin family: Integrin α9 in biology and cancer.

AU - Høye, Anette Melissa

AU - Couchman, John Robert

AU - Wewer, Ulla M.

AU - Yoneda, Atsuko

AU - Fukami, Kiyoko

PY - 2012/5

Y1 - 2012/5

N2 - Integrins are heterodimeric transmembrane receptors regulating cell-cell and cell-extracellular matrix interactions. Of the 24 integrin heterodimers identified in humans, a9ß1 integrin is one of the least studied. a9, together with a4, comprise a more recent evolutionary sub-family of integrins that is only found in vertebrates. Since a9 was thought to have similar functions as a4, due to many shared ligands, it was a rather overlooked integrin until recently, when its importance for survival after birth was highlighted upon investigation of the a9 knockout mouse. a9ß1 is expressed on a wide variety of cell types, interacts with many ligands for example fibronectin, tenascin-C and ADAM12, and has been shown to have important functions in processes such as cell adhesion and migration, lung development, lymphatic and venous valve development, and in wound healing. This has sparked an interest to investigate a9ß1-mediated signaling and its regulation. This review gives an overview of the recent progress in a9ß1-mediated biological and pathological processes, and discusses its potential as a target for cancer diagnosis and therapy.

AB - Integrins are heterodimeric transmembrane receptors regulating cell-cell and cell-extracellular matrix interactions. Of the 24 integrin heterodimers identified in humans, a9ß1 integrin is one of the least studied. a9, together with a4, comprise a more recent evolutionary sub-family of integrins that is only found in vertebrates. Since a9 was thought to have similar functions as a4, due to many shared ligands, it was a rather overlooked integrin until recently, when its importance for survival after birth was highlighted upon investigation of the a9 knockout mouse. a9ß1 is expressed on a wide variety of cell types, interacts with many ligands for example fibronectin, tenascin-C and ADAM12, and has been shown to have important functions in processes such as cell adhesion and migration, lung development, lymphatic and venous valve development, and in wound healing. This has sparked an interest to investigate a9ß1-mediated signaling and its regulation. This review gives an overview of the recent progress in a9ß1-mediated biological and pathological processes, and discusses its potential as a target for cancer diagnosis and therapy.

U2 - 10.1016/j.jbior.2012.03.004

DO - 10.1016/j.jbior.2012.03.004

M3 - Review

VL - 52

SP - 326

EP - 339

JO - Advances in Biological Regulation

JF - Advances in Biological Regulation

SN - 2212-4926

IS - 2

ER -

ID: 40249046