The molecular and morphogenetic basis of pancreas organogenesis

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The molecular and morphogenetic basis of pancreas organogenesis

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The molecular and morphogenetic basis of pancreas organogenesis. / Larsen, Hjalte List; Grapin-Botton, Anne.

In: Seminars in Cell and Developmental Biology, Vol. 66, 12.01.2017, p. 51-68.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Larsen, HL & Grapin-Botton, A 2017, 'The molecular and morphogenetic basis of pancreas organogenesis', Seminars in Cell and Developmental Biology, vol. 66, pp. 51-68. https://doi.org/10.1016/j.semcdb.2017.01.005

APA

Larsen, H. L., & Grapin-Botton, A. (2017). The molecular and morphogenetic basis of pancreas organogenesis. Seminars in Cell and Developmental Biology, 66, 51-68. https://doi.org/10.1016/j.semcdb.2017.01.005

Vancouver

Larsen HL, Grapin-Botton A. The molecular and morphogenetic basis of pancreas organogenesis. Seminars in Cell and Developmental Biology. 2017 Jan 12;66:51-68. https://doi.org/10.1016/j.semcdb.2017.01.005

Author

Larsen, Hjalte List ; Grapin-Botton, Anne. / The molecular and morphogenetic basis of pancreas organogenesis. In: Seminars in Cell and Developmental Biology. 2017 ; Vol. 66. pp. 51-68.

Bibtex

@article{38852a29af354027990b2cf52c62b92b,

title = "The molecular and morphogenetic basis of pancreas organogenesis",

abstract = "The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via its endocrine and exocrine functions. Here we review the essential processes governing the embryonic and early postnatal development of the pancreas discussing both the mechanisms and molecules controlling progenitor specification, expansion and differentiation. We elaborate on how these processes are orchestrated in space and coordinated with morphogenesis. We draw mainly from experiments conducted in the mouse model but also from investigations in other model organisms, complementing a recent comprehensive review of human pancreas development (Jennings et al., 2015) [1]. The understanding of pancreas development in model organisms provides a framework to interpret how human mutations lead to neonatal diabetes and may contribute to other forms of diabetes and to guide the production of desired pancreatic cell types from pluripotent stem cells for therapeutic purposes.",

author = "Larsen, {Hjalte List} and Anne Grapin-Botton",

year = "2017",

month = jan,

day = "12",

doi = "10.1016/j.semcdb.2017.01.005",

language = "English",

volume = "66",

pages = "51--68",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - The molecular and morphogenetic basis of pancreas organogenesis

AU - Larsen, Hjalte List

AU - Grapin-Botton, Anne

PY - 2017/1/12

Y1 - 2017/1/12

N2 - The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via its endocrine and exocrine functions. Here we review the essential processes governing the embryonic and early postnatal development of the pancreas discussing both the mechanisms and molecules controlling progenitor specification, expansion and differentiation. We elaborate on how these processes are orchestrated in space and coordinated with morphogenesis. We draw mainly from experiments conducted in the mouse model but also from investigations in other model organisms, complementing a recent comprehensive review of human pancreas development (Jennings et al., 2015) [1]. The understanding of pancreas development in model organisms provides a framework to interpret how human mutations lead to neonatal diabetes and may contribute to other forms of diabetes and to guide the production of desired pancreatic cell types from pluripotent stem cells for therapeutic purposes.

AB - The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via its endocrine and exocrine functions. Here we review the essential processes governing the embryonic and early postnatal development of the pancreas discussing both the mechanisms and molecules controlling progenitor specification, expansion and differentiation. We elaborate on how these processes are orchestrated in space and coordinated with morphogenesis. We draw mainly from experiments conducted in the mouse model but also from investigations in other model organisms, complementing a recent comprehensive review of human pancreas development (Jennings et al., 2015) [1]. The understanding of pancreas development in model organisms provides a framework to interpret how human mutations lead to neonatal diabetes and may contribute to other forms of diabetes and to guide the production of desired pancreatic cell types from pluripotent stem cells for therapeutic purposes.

U2 - 10.1016/j.semcdb.2017.01.005

DO - 10.1016/j.semcdb.2017.01.005

M3 - Journal article

C2 - 28089869

VL - 66

SP - 51

EP - 68

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

ER -

ID: 172478442