The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB-IGF-1 hybrid protein

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB-IGF-1 hybrid protein. / Bazi, Zahra; Jalili, Mahsa; Hekmatdoost, Azita.

In: Medical Hypotheses, Vol. 81, No. 5, 2013, p. 961-962.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bazi, Z, Jalili, M & Hekmatdoost, A 2013, 'The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB-IGF-1 hybrid protein', Medical Hypotheses, vol. 81, no. 5, pp. 961-962. https://doi.org/10.1016/j.mehy.2013.08.035

APA

Bazi, Z., Jalili, M., & Hekmatdoost, A. (2013). The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB-IGF-1 hybrid protein. Medical Hypotheses, 81(5), 961-962. https://doi.org/10.1016/j.mehy.2013.08.035

Vancouver

Bazi Z, Jalili M, Hekmatdoost A. The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB-IGF-1 hybrid protein. Medical Hypotheses. 2013;81(5):961-962. https://doi.org/10.1016/j.mehy.2013.08.035

Author

Bazi, Zahra ; Jalili, Mahsa ; Hekmatdoost, Azita. / The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB-IGF-1 hybrid protein. In: Medical Hypotheses. 2013 ; Vol. 81, No. 5. pp. 961-962.

Bibtex

@article{02c294f5aeef4903bc64ad9ea28f45da,

title = "The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB-IGF-1 hybrid protein",

abstract = "Regarding to the high prevalence and comorbidities of chronic high blood glucose in diabetic patients and the limited efficacy and current painful treatments. It is necessary to improve new treatments that are non-invasive and long-term for controlling blood glucose. Recent studies have shown that the healthy microflora in different body organs can perform as the gene vectors for expressing different types of gene therapies in situ. We have proposed that by constructing a recombinant Escherichia coli Nissle 1917 that expresses CTB-IGF-1 hybrid gene under control of ompC glucose sensitive promoter, the intestinal glucose level can be regulated. This method in comparison with other methods is a non-invasive way to control the blood glucose orally and it can be used for all types of diabetes.",

author = "Zahra Bazi and Mahsa Jalili and Azita Hekmatdoost",

note = "(Ekstern)",

year = "2013",

doi = "10.1016/j.mehy.2013.08.035",

language = "English",

volume = "81",

pages = "961--962",

journal = "Medical Hypotheses",

issn = "0306-9877",

publisher = "Churchill Livingstone",

number = "5",

}

RIS

TY - JOUR

T1 - The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB-IGF-1 hybrid protein

AU - Bazi, Zahra

AU - Jalili, Mahsa

AU - Hekmatdoost, Azita

N1 - (Ekstern)

PY - 2013

Y1 - 2013

N2 - Regarding to the high prevalence and comorbidities of chronic high blood glucose in diabetic patients and the limited efficacy and current painful treatments. It is necessary to improve new treatments that are non-invasive and long-term for controlling blood glucose. Recent studies have shown that the healthy microflora in different body organs can perform as the gene vectors for expressing different types of gene therapies in situ. We have proposed that by constructing a recombinant Escherichia coli Nissle 1917 that expresses CTB-IGF-1 hybrid gene under control of ompC glucose sensitive promoter, the intestinal glucose level can be regulated. This method in comparison with other methods is a non-invasive way to control the blood glucose orally and it can be used for all types of diabetes.

AB - Regarding to the high prevalence and comorbidities of chronic high blood glucose in diabetic patients and the limited efficacy and current painful treatments. It is necessary to improve new treatments that are non-invasive and long-term for controlling blood glucose. Recent studies have shown that the healthy microflora in different body organs can perform as the gene vectors for expressing different types of gene therapies in situ. We have proposed that by constructing a recombinant Escherichia coli Nissle 1917 that expresses CTB-IGF-1 hybrid gene under control of ompC glucose sensitive promoter, the intestinal glucose level can be regulated. This method in comparison with other methods is a non-invasive way to control the blood glucose orally and it can be used for all types of diabetes.

UR - http://www.scopus.com/inward/record.url?scp=84886774990&partnerID=8YFLogxK

U2 - 10.1016/j.mehy.2013.08.035

DO - 10.1016/j.mehy.2013.08.035

M3 - Journal article

C2 - 24074833

AN - SCOPUS:84886774990

VL - 81

SP - 961

EP - 962

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

IS - 5

ER -

ID: 248338925