The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe?

Research output: Contribution to journal › Review › Research › peer-review

Standard

The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis : friend or foe? / Andersen, Jesper Bøje; Hassel, B A.

In: Cytokine & Growth Factor Reviews, Vol. 17, No. 6, 12.2006, p. 411-21.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Andersen, JB & Hassel, BA 2006, 'The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe?', Cytokine & Growth Factor Reviews, vol. 17, no. 6, pp. 411-21. https://doi.org/10.1016/j.cytogfr.2006.10.001

APA

Andersen, J. B., & Hassel, B. A. (2006). The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe? Cytokine & Growth Factor Reviews, 17(6), 411-21. https://doi.org/10.1016/j.cytogfr.2006.10.001

Vancouver

Andersen JB, Hassel BA. The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe? Cytokine & Growth Factor Reviews. 2006 Dec;17(6):411-21. https://doi.org/10.1016/j.cytogfr.2006.10.001

Author

Andersen, Jesper Bøje ; Hassel, B A. / The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis : friend or foe?. In: Cytokine & Growth Factor Reviews. 2006 ; Vol. 17, No. 6. pp. 411-21.

Bibtex

@article{798f49b7a2f84c36a75b9b6c14b75f13,
title = "The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe?",
abstract = "The interferon-stimulated gene, 15 kDa (ISG15) is an interferon regulated gene that is induced as a primary response to diverse microbial and cell stress stimuli, and encodes the founding member of the ubiquitin-like protein family. ISG15 post-translationally modifies proteins via a pathway parallel to, and partially overlapping with, that of ubiquitin. In addition, ISG15 is released from cells to mediate extracellular cytokine-like activities. Although the biological activities of ISG15 have yet to be fully elucidated, it is clear that ISG15 has the capacity to modulate diverse cellular and physiologic functions. Consistent with this view, alterations in the ISG15 pathway have been identified in human tumors and in tumor cell lines. Here we review evidence of a role for ISG15 as an endogenous tumor suppressor that, when dysregulated in malignant cells, can be subverted to promote oncogenesis.",
keywords = "Amino Acid Sequence, Antineoplastic Agents, Cytokines, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Humans, Interferons, Models, Biological, Molecular Sequence Data, Neoplasms, Protein Processing, Post-Translational, Ubiquitin, Ubiquitins",
author = "Andersen, {Jesper B{\o}je} and Hassel, {B A}",
year = "2006",
month = dec,
doi = "10.1016/j.cytogfr.2006.10.001",
language = "English",
volume = "17",
pages = "411--21",
journal = "Cytokine & Growth Factor Reviews",
issn = "1359-6101",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis

T2 - friend or foe?

AU - Andersen, Jesper Bøje

AU - Hassel, B A

PY - 2006/12

Y1 - 2006/12

N2 - The interferon-stimulated gene, 15 kDa (ISG15) is an interferon regulated gene that is induced as a primary response to diverse microbial and cell stress stimuli, and encodes the founding member of the ubiquitin-like protein family. ISG15 post-translationally modifies proteins via a pathway parallel to, and partially overlapping with, that of ubiquitin. In addition, ISG15 is released from cells to mediate extracellular cytokine-like activities. Although the biological activities of ISG15 have yet to be fully elucidated, it is clear that ISG15 has the capacity to modulate diverse cellular and physiologic functions. Consistent with this view, alterations in the ISG15 pathway have been identified in human tumors and in tumor cell lines. Here we review evidence of a role for ISG15 as an endogenous tumor suppressor that, when dysregulated in malignant cells, can be subverted to promote oncogenesis.

AB - The interferon-stimulated gene, 15 kDa (ISG15) is an interferon regulated gene that is induced as a primary response to diverse microbial and cell stress stimuli, and encodes the founding member of the ubiquitin-like protein family. ISG15 post-translationally modifies proteins via a pathway parallel to, and partially overlapping with, that of ubiquitin. In addition, ISG15 is released from cells to mediate extracellular cytokine-like activities. Although the biological activities of ISG15 have yet to be fully elucidated, it is clear that ISG15 has the capacity to modulate diverse cellular and physiologic functions. Consistent with this view, alterations in the ISG15 pathway have been identified in human tumors and in tumor cell lines. Here we review evidence of a role for ISG15 as an endogenous tumor suppressor that, when dysregulated in malignant cells, can be subverted to promote oncogenesis.

KW - Amino Acid Sequence

KW - Antineoplastic Agents

KW - Cytokines

KW - Gene Expression Regulation, Neoplastic

KW - Genes, Tumor Suppressor

KW - Humans

KW - Interferons

KW - Models, Biological

KW - Molecular Sequence Data

KW - Neoplasms

KW - Protein Processing, Post-Translational

KW - Ubiquitin

KW - Ubiquitins

U2 - 10.1016/j.cytogfr.2006.10.001

DO - 10.1016/j.cytogfr.2006.10.001

M3 - Review

C2 - 17097911

VL - 17

SP - 411

EP - 421

JO - Cytokine & Growth Factor Reviews

JF - Cytokine & Growth Factor Reviews

SN - 1359-6101

IS - 6

ER -

ID: 97140370