The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer. / Strandby, Rune B; Svendsen, Lars B; Ambrus, Rikard; Rostved, Andreas A; Hasselby, Jane P; Achiam, Michael P.

In: Journal of Cytology, Vol. 37, No. 1, 17.01.2020, p. 40-45.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Strandby, RB, Svendsen, LB, Ambrus, R, Rostved, AA, Hasselby, JP & Achiam, MP 2020, 'The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer', Journal of Cytology, vol. 37, no. 1, pp. 40-45. https://doi.org/10.4103/JOC.JOC_164_18

APA

Strandby, R. B., Svendsen, L. B., Ambrus, R., Rostved, A. A., Hasselby, J. P., & Achiam, M. P. (2020). The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer. Journal of Cytology, 37(1), 40-45. https://doi.org/10.4103/JOC.JOC_164_18

Vancouver

Strandby RB, Svendsen LB, Ambrus R, Rostved AA, Hasselby JP, Achiam MP. The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer. Journal of Cytology. 2020 Jan 17;37(1):40-45. https://doi.org/10.4103/JOC.JOC_164_18

Author

Strandby, Rune B ; Svendsen, Lars B ; Ambrus, Rikard ; Rostved, Andreas A ; Hasselby, Jane P ; Achiam, Michael P. / The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer. In: Journal of Cytology. 2020 ; Vol. 37, No. 1. pp. 40-45.

Bibtex

@article{3757f2bf5f524850b326ab90e3d273d8,

title = "The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer",

abstract = "Context: The utility of peritoneal washing cytology in patients with gastroesophageal junction cancer has not been thoroughly evaluated.Aims: The study aimed to determine the incidence of free peritoneal tumor cells by peritoneal washing cytology before and after neoadjuvant chemotherapy using conventional cytopathological methods and immunohistochemical staining for the analysis of peritoneal washings.Settings and Design: A prospective study conducted at a single tertiary referral hospital.Materials and Methods: Patients with gastroesophageal junction cancer and without suspicion of intra- or extraabdominal metastases before the staging laparoscopy were prospectively and consecutively enrolled. Peritoneal washing cytology was performed at staging laparoscopy (primary cytology) and after neoadjuvant chemotherapy during robot-assisted or open resection (secondary cytology). Peritoneal fluid samples were analyzed by conventional cytology and an immunohistochemical panel.Results: Overall, 81 patients met the primary inclusion criteria. During primary cytology, positive cytology without overt metastases (C1M0) was detected in three patients (3.8%) while five patients (6.3%) had overt intra-abdominal metastases but negative cytology (C0M1). None of the patients with C1M0 underwent surgery due to extra-abdominal (n = 1) or intra-abdominal metastases (n = 2), and the overall survival was 4, 7, and 14 months. During secondary cytology, no patients with free peritoneal tumor cells were identified, but seven patients were classified as C0M1 (10.9%).Conclusions: The incidence of C1M0 was 3.8% and 0% before and after neoadjuvant chemotherapy, respectively in patients with gastroesophageal junction cancer. Free peritoneal tumor cells were not identified in several patients with intra-abdominal metastases suggesting that peritoneal washing cytology with conventional cytology and immunohistochemical staining lack sensitivity.",

author = "Strandby, {Rune B} and Svendsen, {Lars B} and Rikard Ambrus and Rostved, {Andreas A} and Hasselby, {Jane P} and Achiam, {Michael P}",

note = "Copyright: {\textcopyright} 2019 Journal of Cytology.",

year = "2020",

month = jan,

day = "17",

doi = "10.4103/JOC.JOC_164_18",

language = "English",

volume = "37",

pages = "40--45",

journal = "Journal of Cytology",

issn = "0970-9371",

publisher = "Medknow Publications and Media Pvt. Ltd.",

number = "1",

}

RIS

TY - JOUR

T1 - The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer

AU - Strandby, Rune B

AU - Svendsen, Lars B

AU - Ambrus, Rikard

AU - Rostved, Andreas A

AU - Hasselby, Jane P

AU - Achiam, Michael P

PY - 2020/1/17

Y1 - 2020/1/17

N2 - Context: The utility of peritoneal washing cytology in patients with gastroesophageal junction cancer has not been thoroughly evaluated.Aims: The study aimed to determine the incidence of free peritoneal tumor cells by peritoneal washing cytology before and after neoadjuvant chemotherapy using conventional cytopathological methods and immunohistochemical staining for the analysis of peritoneal washings.Settings and Design: A prospective study conducted at a single tertiary referral hospital.Materials and Methods: Patients with gastroesophageal junction cancer and without suspicion of intra- or extraabdominal metastases before the staging laparoscopy were prospectively and consecutively enrolled. Peritoneal washing cytology was performed at staging laparoscopy (primary cytology) and after neoadjuvant chemotherapy during robot-assisted or open resection (secondary cytology). Peritoneal fluid samples were analyzed by conventional cytology and an immunohistochemical panel.Results: Overall, 81 patients met the primary inclusion criteria. During primary cytology, positive cytology without overt metastases (C1M0) was detected in three patients (3.8%) while five patients (6.3%) had overt intra-abdominal metastases but negative cytology (C0M1). None of the patients with C1M0 underwent surgery due to extra-abdominal (n = 1) or intra-abdominal metastases (n = 2), and the overall survival was 4, 7, and 14 months. During secondary cytology, no patients with free peritoneal tumor cells were identified, but seven patients were classified as C0M1 (10.9%).Conclusions: The incidence of C1M0 was 3.8% and 0% before and after neoadjuvant chemotherapy, respectively in patients with gastroesophageal junction cancer. Free peritoneal tumor cells were not identified in several patients with intra-abdominal metastases suggesting that peritoneal washing cytology with conventional cytology and immunohistochemical staining lack sensitivity.

AB - Context: The utility of peritoneal washing cytology in patients with gastroesophageal junction cancer has not been thoroughly evaluated.Aims: The study aimed to determine the incidence of free peritoneal tumor cells by peritoneal washing cytology before and after neoadjuvant chemotherapy using conventional cytopathological methods and immunohistochemical staining for the analysis of peritoneal washings.Settings and Design: A prospective study conducted at a single tertiary referral hospital.Materials and Methods: Patients with gastroesophageal junction cancer and without suspicion of intra- or extraabdominal metastases before the staging laparoscopy were prospectively and consecutively enrolled. Peritoneal washing cytology was performed at staging laparoscopy (primary cytology) and after neoadjuvant chemotherapy during robot-assisted or open resection (secondary cytology). Peritoneal fluid samples were analyzed by conventional cytology and an immunohistochemical panel.Results: Overall, 81 patients met the primary inclusion criteria. During primary cytology, positive cytology without overt metastases (C1M0) was detected in three patients (3.8%) while five patients (6.3%) had overt intra-abdominal metastases but negative cytology (C0M1). None of the patients with C1M0 underwent surgery due to extra-abdominal (n = 1) or intra-abdominal metastases (n = 2), and the overall survival was 4, 7, and 14 months. During secondary cytology, no patients with free peritoneal tumor cells were identified, but seven patients were classified as C0M1 (10.9%).Conclusions: The incidence of C1M0 was 3.8% and 0% before and after neoadjuvant chemotherapy, respectively in patients with gastroesophageal junction cancer. Free peritoneal tumor cells were not identified in several patients with intra-abdominal metastases suggesting that peritoneal washing cytology with conventional cytology and immunohistochemical staining lack sensitivity.

U2 - 10.4103/JOC.JOC_164_18

DO - 10.4103/JOC.JOC_164_18

M3 - Journal article

C2 - 31942097

VL - 37

SP - 40

EP - 45

JO - Journal of Cytology

JF - Journal of Cytology

SN - 0970-9371

IS - 1

ER -

ID: 249626611