The impact of loading, unloading, ageing and injury on the human tendon
Research output: Contribution to journal › Review › Research › peer-review
A tendon transfers force from the contracting muscle to the skeletal system to produce movement and is therefore a crucial component of the entire muscle-tendon complex and its function. However, tendon research has for some time focused on mechanical properties without any major appreciation of potential cellular and molecular changes. At the same time, methodological developments have permitted determination of the mechanical properties of human tendons in vivo, which was previously not possible. Here we review the current understanding of how tendons respond to loading, unloading, ageing and injury from cellular, molecular and mechanical points of view. A mechanistic understanding of tendon tissue adaptation will be vital for development of adequate guidelines in physical training and rehabilitation, as well as for optimal injury treatment. (Figure presented.).
Original language | English |
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Journal | Journal of Physiology |
Volume | 597 |
Issue number | 5 |
Pages (from-to) | 1283-1298 |
ISSN | 0022-3751 |
DOIs | |
Publication status | Published - Mar 2019 |
- collagen, extracellular matrix, tendon fibroblasts, tendon structure, viscoelastic properties
Research areas
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395417/pdf/TJP-597-1283.pdf
Final published version
ID: 240634125