The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia. / Kalliokoski, Otto Henrik; Abelson, Klas; Koch, Janne; Boschian, Anna; Thormose, Sarah F; Fauerby, Natasha; Rasmussen, Rune Skovgaard; Johansen, Flemming Fryd; Hau, Jann.

In: In Vivo, Vol. 24, No. 5, 09.2010, p. 641-646.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kalliokoski, OH, Abelson, K, Koch, J, Boschian, A, Thormose, SF, Fauerby, N, Rasmussen, RS, Johansen, FF & Hau, J 2010, 'The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia', In Vivo, vol. 24, no. 5, pp. 641-646.

APA

Kalliokoski, O. H., Abelson, K., Koch, J., Boschian, A., Thormose, S. F., Fauerby, N., Rasmussen, R. S., Johansen, F. F., & Hau, J. (2010). The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia. In Vivo, 24(5), 641-646.

Vancouver

Kalliokoski OH, Abelson K, Koch J, Boschian A, Thormose SF, Fauerby N et al. The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia. In Vivo. 2010 Sep;24(5):641-646.

Author

Kalliokoski, Otto Henrik ; Abelson, Klas ; Koch, Janne ; Boschian, Anna ; Thormose, Sarah F ; Fauerby, Natasha ; Rasmussen, Rune Skovgaard ; Johansen, Flemming Fryd ; Hau, Jann. / The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia. In: In Vivo. 2010 ; Vol. 24, No. 5. pp. 641-646.

Bibtex

@article{9a9f9150c85245468f50f5a95a579d24,
title = "The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia",
abstract = "The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.",
author = "Kalliokoski, {Otto Henrik} and Klas Abelson and Janne Koch and Anna Boschian and Thormose, {Sarah F} and Natasha Fauerby and Rasmussen, {Rune Skovgaard} and Johansen, {Flemming Fryd} and Jann Hau",
year = "2010",
month = sep,
language = "English",
volume = "24",
pages = "641--646",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - The effect of voluntarily ingested buprenorphine on rats subjected to surgically induced global cerebral ischaemia

AU - Kalliokoski, Otto Henrik

AU - Abelson, Klas

AU - Koch, Janne

AU - Boschian, Anna

AU - Thormose, Sarah F

AU - Fauerby, Natasha

AU - Rasmussen, Rune Skovgaard

AU - Johansen, Flemming Fryd

AU - Hau, Jann

PY - 2010/9

Y1 - 2010/9

N2 - The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.

AB - The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.

M3 - Journal article

VL - 24

SP - 641

EP - 646

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 5

ER -

ID: 33811736