The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism

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The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. / Madsen, Claus Desler; Lykke, Anne; Rasmussen, Lene Juel.

In: Journal of Nucleic Acids, Vol. 2010, 01.01.2010.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Madsen, CD, Lykke, A & Rasmussen, LJ 2010, 'The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism', Journal of Nucleic Acids, vol. 2010. https://doi.org/10.4061/2010/701518

APA

Madsen, C. D., Lykke, A., & Rasmussen, L. J. (2010). The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. Journal of Nucleic Acids, 2010. https://doi.org/10.4061/2010/701518

Vancouver

Madsen CD, Lykke A, Rasmussen LJ. The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. Journal of Nucleic Acids. 2010 Jan 1;2010. https://doi.org/10.4061/2010/701518

Author

Madsen, Claus Desler ; Lykke, Anne ; Rasmussen, Lene Juel. / The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. In: Journal of Nucleic Acids. 2010 ; Vol. 2010.

Bibtex

@article{ff6c1f96dba3470ba57730aa53d6a133,
title = "The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism",
abstract = "Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.",
author = "Madsen, {Claus Desler} and Anne Lykke and Rasmussen, {Lene Juel}",
year = "2010",
month = jan,
day = "1",
doi = "10.4061/2010/701518",
language = "English",
volume = "2010",
journal = "Journal of Nucleic Acids",
issn = "2090-0201",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism

AU - Madsen, Claus Desler

AU - Lykke, Anne

AU - Rasmussen, Lene Juel

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.

AB - Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.

U2 - 10.4061/2010/701518

DO - 10.4061/2010/701518

M3 - Journal article

C2 - 20862377

VL - 2010

JO - Journal of Nucleic Acids

JF - Journal of Nucleic Acids

SN - 2090-0201

ER -

ID: 33489920