The Danish Fetal Medicine Database

The Danish Fetal Medicine Database: establishment, organisation and quality assessment of the first trimester screening programme for trisomy 21 in Denmark 2008-2012

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The Danish Fetal Medicine Database : establishment, organisation and quality assessment of the first trimester screening programme for trisomy 21 in Denmark 2008-2012. / Ekelund, Charlotte K; Petersen, Olav B; Jørgensen, Finn S; Kjaergaard, Susanne; Larsen, Torben; Olesen, Annette W; Skibsted, Lillian; Skovbo, Peter; Sommer, Steffen; Sperling, Lene; Stavnstrup, Benedicte; Størup, Birgitte; Zingenberg, Helle; Uldbjerg, Niels; Miltoft, Caroline B; Noergaard, Lasse; Wulff, Camilla B; Tabor, Ann; The Danish Fetal Medicine Research Group.

In: Acta Obstetrica et Gynecologica, Vol. 94, No. 6, 06.2015, p. 577–583.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ekelund, CK, Petersen, OB, Jørgensen, FS, Kjaergaard, S, Larsen, T, Olesen, AW, Skibsted, L, Skovbo, P, Sommer, S, Sperling, L, Stavnstrup, B, Størup, B, Zingenberg, H, Uldbjerg, N, Miltoft, CB, Noergaard, L, Wulff, CB, Tabor, A & The Danish Fetal Medicine Research Group 2015, 'The Danish Fetal Medicine Database: establishment, organisation and quality assessment of the first trimester screening programme for trisomy 21 in Denmark 2008-2012', Acta Obstetrica et Gynecologica, vol. 94, no. 6, pp. 577–583. https://doi.org/10.1111/aogs.12581

APA

Ekelund, C. K., Petersen, O. B., Jørgensen, F. S., Kjaergaard, S., Larsen, T., Olesen, A. W., Skibsted, L., Skovbo, P., Sommer, S., Sperling, L., Stavnstrup, B., Størup, B., Zingenberg, H., Uldbjerg, N., Miltoft, C. B., Noergaard, L., Wulff, C. B., Tabor, A., & The Danish Fetal Medicine Research Group (2015). The Danish Fetal Medicine Database: establishment, organisation and quality assessment of the first trimester screening programme for trisomy 21 in Denmark 2008-2012. Acta Obstetrica et Gynecologica, 94(6), 577–583. https://doi.org/10.1111/aogs.12581

Vancouver

Ekelund CK, Petersen OB, Jørgensen FS, Kjaergaard S, Larsen T, Olesen AW et al. The Danish Fetal Medicine Database: establishment, organisation and quality assessment of the first trimester screening programme for trisomy 21 in Denmark 2008-2012. Acta Obstetrica et Gynecologica. 2015 Jun;94(6):577–583. https://doi.org/10.1111/aogs.12581

Author

Ekelund, Charlotte K ; Petersen, Olav B ; Jørgensen, Finn S ; Kjaergaard, Susanne ; Larsen, Torben ; Olesen, Annette W ; Skibsted, Lillian ; Skovbo, Peter ; Sommer, Steffen ; Sperling, Lene ; Stavnstrup, Benedicte ; Størup, Birgitte ; Zingenberg, Helle ; Uldbjerg, Niels ; Miltoft, Caroline B ; Noergaard, Lasse ; Wulff, Camilla B ; Tabor, Ann ; The Danish Fetal Medicine Research Group. / The Danish Fetal Medicine Database : establishment, organisation and quality assessment of the first trimester screening programme for trisomy 21 in Denmark 2008-2012. In: Acta Obstetrica et Gynecologica. 2015 ; Vol. 94, No. 6. pp. 577–583.

Bibtex

@article{dd21cb2f658348c79875ea300feacee4,

title = "The Danish Fetal Medicine Database: establishment, organisation and quality assessment of the first trimester screening programme for trisomy 21 in Denmark 2008-2012",

abstract = "OBJECTIVE: To describe the establishment and organization of the Danish Fetal Medicine Database and to report national results of first-trimester combined screening for trisomy 21 in the 5-year period 2008-2012.DESIGN: National register study using prospectively collected first-trimester screening data from the Danish Fetal Medicine Database.POPULATION: Pregnant women in Denmark undergoing first-trimester screening for trisomy 21.METHODS: Data on maternal characteristics, biochemical and ultrasonic markers are continuously sent electronically from local fetal medicine databases (Astraia Gmbh software) to a central national database. Data are linked to outcome data from the National Birth Register, the National Patient Register and the National Cytogenetic Register via the mother's unique personal registration number. First-trimester screening data from 2008 to 2012 were retrieved.MAIN OUTCOME MEASURES: Screening performance was assessed for the years 2008-2012 by calculating detection rates and screen-positive rates.RESULTS: A total of 268 342 first-trimester risk assessments for trisomy 21 were performed in singleton pregnancies. Participation rate in first-trimester screening was >90%. The national screen-positive rate increased from 3.6% in 2008 to 4.7% in 2012. The national detection rate of trisomy 21 was reported to be between 82 and 90% in the 5-year period.CONCLUSION: A national fetal medicine database has been successfully established in Denmark. Results from the database have shown that at a national level first-trimester screening performance for trisomy 21 is high with a low screen-positive rate and a high detection rate.",

author = "Ekelund, {Charlotte K} and Petersen, {Olav B} and J{\o}rgensen, {Finn S} and Susanne Kjaergaard and Torben Larsen and Olesen, {Annette W} and Lillian Skibsted and Peter Skovbo and Steffen Sommer and Lene Sperling and Benedicte Stavnstrup and Birgitte St{\o}rup and Helle Zingenberg and Niels Uldbjerg and Miltoft, {Caroline B} and Lasse Noergaard and Wulff, {Camilla B} and Ann Tabor and {The Danish Fetal Medicine Research Group}",

note = "{\textcopyright} 2015 Nordic Federation of Societies of Obstetrics and Gynecology.",

year = "2015",

month = jun,

doi = "10.1111/aogs.12581",

language = "English",

volume = "94",

pages = "577–583",

journal = "Acta Obstetricia et Gynecologica Scandinavica",

issn = "0001-6349",

publisher = "JohnWiley & Sons Ltd",

number = "6",

}

RIS

TY - JOUR

T1 - The Danish Fetal Medicine Database

T2 - establishment, organisation and quality assessment of the first trimester screening programme for trisomy 21 in Denmark 2008-2012

AU - Ekelund, Charlotte K

AU - Petersen, Olav B

AU - Jørgensen, Finn S

AU - Kjaergaard, Susanne

AU - Larsen, Torben

AU - Olesen, Annette W

AU - Skibsted, Lillian

AU - Skovbo, Peter

AU - Sommer, Steffen

AU - Sperling, Lene

AU - Stavnstrup, Benedicte

AU - Størup, Birgitte

AU - Zingenberg, Helle

AU - Uldbjerg, Niels

AU - Miltoft, Caroline B

AU - Noergaard, Lasse

AU - Wulff, Camilla B

AU - Tabor, Ann

AU - The Danish Fetal Medicine Research Group

PY - 2015/6

Y1 - 2015/6

N2 - OBJECTIVE: To describe the establishment and organization of the Danish Fetal Medicine Database and to report national results of first-trimester combined screening for trisomy 21 in the 5-year period 2008-2012.DESIGN: National register study using prospectively collected first-trimester screening data from the Danish Fetal Medicine Database.POPULATION: Pregnant women in Denmark undergoing first-trimester screening for trisomy 21.METHODS: Data on maternal characteristics, biochemical and ultrasonic markers are continuously sent electronically from local fetal medicine databases (Astraia Gmbh software) to a central national database. Data are linked to outcome data from the National Birth Register, the National Patient Register and the National Cytogenetic Register via the mother's unique personal registration number. First-trimester screening data from 2008 to 2012 were retrieved.MAIN OUTCOME MEASURES: Screening performance was assessed for the years 2008-2012 by calculating detection rates and screen-positive rates.RESULTS: A total of 268 342 first-trimester risk assessments for trisomy 21 were performed in singleton pregnancies. Participation rate in first-trimester screening was >90%. The national screen-positive rate increased from 3.6% in 2008 to 4.7% in 2012. The national detection rate of trisomy 21 was reported to be between 82 and 90% in the 5-year period.CONCLUSION: A national fetal medicine database has been successfully established in Denmark. Results from the database have shown that at a national level first-trimester screening performance for trisomy 21 is high with a low screen-positive rate and a high detection rate.

AB - OBJECTIVE: To describe the establishment and organization of the Danish Fetal Medicine Database and to report national results of first-trimester combined screening for trisomy 21 in the 5-year period 2008-2012.DESIGN: National register study using prospectively collected first-trimester screening data from the Danish Fetal Medicine Database.POPULATION: Pregnant women in Denmark undergoing first-trimester screening for trisomy 21.METHODS: Data on maternal characteristics, biochemical and ultrasonic markers are continuously sent electronically from local fetal medicine databases (Astraia Gmbh software) to a central national database. Data are linked to outcome data from the National Birth Register, the National Patient Register and the National Cytogenetic Register via the mother's unique personal registration number. First-trimester screening data from 2008 to 2012 were retrieved.MAIN OUTCOME MEASURES: Screening performance was assessed for the years 2008-2012 by calculating detection rates and screen-positive rates.RESULTS: A total of 268 342 first-trimester risk assessments for trisomy 21 were performed in singleton pregnancies. Participation rate in first-trimester screening was >90%. The national screen-positive rate increased from 3.6% in 2008 to 4.7% in 2012. The national detection rate of trisomy 21 was reported to be between 82 and 90% in the 5-year period.CONCLUSION: A national fetal medicine database has been successfully established in Denmark. Results from the database have shown that at a national level first-trimester screening performance for trisomy 21 is high with a low screen-positive rate and a high detection rate.

U2 - 10.1111/aogs.12581

DO - 10.1111/aogs.12581

M3 - Journal article

C2 - 25597330

VL - 94

SP - 577

EP - 583

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 6

ER -

ID: 137159573