Telomere length is reduced in 9- to 16-year-old girls exposed to gestational diabetes in utero
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Telomere length is reduced in 9- to 16-year-old girls exposed to gestational diabetes in utero. / Hjort, Line; Vryer, Regan; Grunnet, Louise G; Burgner, David; Olsen, Sjurdur F; Saffery, Richard; Vaag, Allan.
In: Diabetologia, Vol. 61, No. 4, 2018, p. 870-880.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Telomere length is reduced in 9- to 16-year-old girls exposed to gestational diabetes in utero
AU - Hjort, Line
AU - Vryer, Regan
AU - Grunnet, Louise G
AU - Burgner, David
AU - Olsen, Sjurdur F
AU - Saffery, Richard
AU - Vaag, Allan
PY - 2018
Y1 - 2018
N2 - AIMS/HYPOTHESIS: Shortened telomere length is a marker of cell damage and is associated with oxidative stress, chronic inflammation and metabolic disease. We hypothesised that the offspring of women with gestational diabetes mellitus (GDM) with increased risk of cardiovascular and metabolic diseases might exhibit shorter telomere length.METHODS: We investigated telomere length in 439 GDM and 469 control group offspring, aged between 9 and 16 years, recruited from the Danish National Birth Cohort. Relative telomere length was measured in peripheral blood DNA (n = 908) using a quantitative PCR approach. Multivariate regression analysis was used to investigate the association between mothers' GDM status and telomere length in the offspring.RESULTS: Female offspring had longer telomeres than males. Offspring of mothers with GDM had significantly shorter telomere length than control offspring, but this difference was observed only in girls. There was a negative association between telomere length and GDM exposure among the female offspring (14% shorter telomeres, p = 0.003) following adjustment for the age of the offspring. Telomere length in female offspring was negatively associated with fasting insulin levels and HOMA-IR (p = 0.03). Maternal age, smoking, gestational age, birthweight and the offspring's anthropometric characteristics were not associated with telomere length (p ≥ 0.1).CONCLUSIONS/INTERPRETATION: The 9- to 16-year-old girls of mothers with GDM had shorter telomeres than those from the control population. Further studies are needed to understand the extent to which shortened telomere length predicts and/or contributes to the increased risk of disease later in life among the offspring of women with GDM.
AB - AIMS/HYPOTHESIS: Shortened telomere length is a marker of cell damage and is associated with oxidative stress, chronic inflammation and metabolic disease. We hypothesised that the offspring of women with gestational diabetes mellitus (GDM) with increased risk of cardiovascular and metabolic diseases might exhibit shorter telomere length.METHODS: We investigated telomere length in 439 GDM and 469 control group offspring, aged between 9 and 16 years, recruited from the Danish National Birth Cohort. Relative telomere length was measured in peripheral blood DNA (n = 908) using a quantitative PCR approach. Multivariate regression analysis was used to investigate the association between mothers' GDM status and telomere length in the offspring.RESULTS: Female offspring had longer telomeres than males. Offspring of mothers with GDM had significantly shorter telomere length than control offspring, but this difference was observed only in girls. There was a negative association between telomere length and GDM exposure among the female offspring (14% shorter telomeres, p = 0.003) following adjustment for the age of the offspring. Telomere length in female offspring was negatively associated with fasting insulin levels and HOMA-IR (p = 0.03). Maternal age, smoking, gestational age, birthweight and the offspring's anthropometric characteristics were not associated with telomere length (p ≥ 0.1).CONCLUSIONS/INTERPRETATION: The 9- to 16-year-old girls of mothers with GDM had shorter telomeres than those from the control population. Further studies are needed to understand the extent to which shortened telomere length predicts and/or contributes to the increased risk of disease later in life among the offspring of women with GDM.
KW - Adolescent
KW - Adult
KW - Anthropometry
KW - Birth Weight
KW - Blood Glucose/metabolism
KW - Child
KW - Cohort Studies
KW - Denmark
KW - Diabetes, Gestational/physiopathology
KW - Female
KW - Gestational Age
KW - Humans
KW - Insulin/blood
KW - K562 Cells
KW - Male
KW - Multivariate Analysis
KW - Polymerase Chain Reaction
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Sex Factors
KW - Telomere Shortening
U2 - 10.1007/s00125-018-4549-7
DO - 10.1007/s00125-018-4549-7
M3 - Journal article
C2 - 29362826
VL - 61
SP - 870
EP - 880
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 4
ER -
ID: 210924572