T-cell response in human leishmaniasis

Research output: Contribution to journal › Journal article › Research › peer-review

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T-cell response in human leishmaniasis. / Kharazmi, A; Kemp, K; Ismail, A; Gasim, S; Gaafar, A; Kurtzhals, J A; El Hassan, A M; Theander, T G; Kemp, M.

In: Immunology Letters, Vol. 65, No. 1-2, 1999, p. 105-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kharazmi, A, Kemp, K, Ismail, A, Gasim, S, Gaafar, A, Kurtzhals, JA, El Hassan, AM, Theander, TG & Kemp, M 1999, 'T-cell response in human leishmaniasis', Immunology Letters, vol. 65, no. 1-2, pp. 105-8.

APA

Kharazmi, A., Kemp, K., Ismail, A., Gasim, S., Gaafar, A., Kurtzhals, J. A., El Hassan, A. M., Theander, T. G., & Kemp, M. (1999). T-cell response in human leishmaniasis. Immunology Letters, 65(1-2), 105-8.

Vancouver

Kharazmi A, Kemp K, Ismail A, Gasim S, Gaafar A, Kurtzhals JA et al. T-cell response in human leishmaniasis. Immunology Letters. 1999;65(1-2):105-8.

Author

Kharazmi, A ; Kemp, K ; Ismail, A ; Gasim, S ; Gaafar, A ; Kurtzhals, J A ; El Hassan, A M ; Theander, T G ; Kemp, M. / T-cell response in human leishmaniasis. In: Immunology Letters. 1999 ; Vol. 65, No. 1-2. pp. 105-8.

Bibtex

@article{2da1c720a0d811dd86a6000ea68e967b,
title = "T-cell response in human leishmaniasis",
abstract = "In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.",
author = "A Kharazmi and K Kemp and A Ismail and S Gasim and A Gaafar and Kurtzhals, {J A} and {El Hassan}, {A M} and Theander, {T G} and M Kemp",
note = "Keywords: Antigens, Protozoan; Cytokines; Humans; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; T-Lymphocytes",
year = "1999",
language = "English",
volume = "65",
pages = "105--8",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - T-cell response in human leishmaniasis

AU - Kharazmi, A

AU - Kemp, K

AU - Ismail, A

AU - Gasim, S

AU - Gaafar, A

AU - Kurtzhals, J A

AU - El Hassan, A M

AU - Theander, T G

AU - Kemp, M

N1 - Keywords: Antigens, Protozoan; Cytokines; Humans; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; T-Lymphocytes

PY - 1999

Y1 - 1999

N2 - In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.

AB - In the present communication we provide evidence for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis. Our data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients. Lymphocytes from individuals recovered from cutaneous leishmaniasis (CL) responded by IFN-gamma production following stimulation with Leishmania antigens whereas cells from patients recovered from visceral leishmaniasis (VL) showed a mixed pattern of IFN-gamma and IL-4 responses. The cells producing these cytokines were predominantly CD4+. Furthermore, IL-10 plays an important role in the development of post kala azar dermal leishmaniasis (PKDL) from VL. The balance between the parasitic-specific T-cell response plays an important regulatory role in determining the outcome of Leishmania infections in humans.

M3 - Journal article

C2 - 10065635

VL - 65

SP - 105

EP - 108

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

IS - 1-2

ER -

ID: 6765968