Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis

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Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis. / Egeberg, A; Andersen, Y M F; Halling-Overgaard, A-S; Alignahi, F; Thyssen, J P; Burge, R; Mallbris, L.

In: Journal of the European Academy of Dermatology and Venereology : JEADV, Vol. 34, No. 1, 2020, p. 39-46.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Egeberg, A, Andersen, YMF, Halling-Overgaard, A-S, Alignahi, F, Thyssen, JP, Burge, R & Mallbris, L 2020, 'Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis', Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 34, no. 1, pp. 39-46. https://doi.org/10.1111/jdv.15920

APA

Egeberg, A., Andersen, Y. M. F., Halling-Overgaard, A-S., Alignahi, F., Thyssen, J. P., Burge, R., & Mallbris, L. (2020). Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis. Journal of the European Academy of Dermatology and Venereology : JEADV, 34(1), 39-46. https://doi.org/10.1111/jdv.15920

Vancouver

Egeberg A, Andersen YMF, Halling-Overgaard A-S, Alignahi F, Thyssen JP, Burge R et al. Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis. Journal of the European Academy of Dermatology and Venereology : JEADV. 2020;34(1):39-46. https://doi.org/10.1111/jdv.15920

Author

Egeberg, A ; Andersen, Y M F ; Halling-Overgaard, A-S ; Alignahi, F ; Thyssen, J P ; Burge, R ; Mallbris, L. / Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis. In: Journal of the European Academy of Dermatology and Venereology : JEADV. 2020 ; Vol. 34, No. 1. pp. 39-46.

Bibtex

@article{33dd25cfe7ad4ddc97015bdd704a84d6,
title = "Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis",
abstract = "Several novel biologics are available or in development for moderate-to-severe plaque psoriasis. These drugs may differ in time until Psoriasis Area and Severity Index (PASI) response is obtained. In this systematic review, we examined the time to onset of action for interleukin (IL)-17 and IL-23 agents in the treatment of psoriasis. The primary objective was the weighted mean time needed for 25{\%} and 50{\%} of patients with psoriasis to achieve PASI90. The medical databases PubMed, Web of Science and EMBASE were searched using the following terms: psoriasis AND (ixekizumab OR secukinumab OR brodalumab OR risankizumab OR guselkumab OR tildrakizumab). A total of 27 studies were included for data extraction and qualitative synthesis, and 26 of these were quantitatively analysed. The shortest time to 25{\%} and 50{\%} of patients to achieved PASI90 were seen with brodalumab 210 mg every 2 weeks (Q2W; 3.5 weeks and 6.2 weeks, respectively) followed by ixekizumab 80 mg Q2W (4.1 and 7.4 weeks, respectively) and ixekizumab 80 mg Q4W (4.6 and 8.1 weeks, respectively) dosages. In conclusion, clinical trials yielded shorter time to onset of action in studies assessing approved dosing ranges of IL-17 inhibitors compared with studies assessing IL-23 inhibitors.",
author = "A Egeberg and Andersen, {Y M F} and A-S Halling-Overgaard and F Alignahi and Thyssen, {J P} and R Burge and L Mallbris",
note = "{\circledC} 2019 European Academy of Dermatology and Venereology.",
year = "2020",
doi = "10.1111/jdv.15920",
language = "English",
volume = "34",
pages = "39--46",
journal = "Journal of the European Academy of Dermatology and Venereology",
issn = "0926-9959",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis

AU - Egeberg, A

AU - Andersen, Y M F

AU - Halling-Overgaard, A-S

AU - Alignahi, F

AU - Thyssen, J P

AU - Burge, R

AU - Mallbris, L

N1 - © 2019 European Academy of Dermatology and Venereology.

PY - 2020

Y1 - 2020

N2 - Several novel biologics are available or in development for moderate-to-severe plaque psoriasis. These drugs may differ in time until Psoriasis Area and Severity Index (PASI) response is obtained. In this systematic review, we examined the time to onset of action for interleukin (IL)-17 and IL-23 agents in the treatment of psoriasis. The primary objective was the weighted mean time needed for 25% and 50% of patients with psoriasis to achieve PASI90. The medical databases PubMed, Web of Science and EMBASE were searched using the following terms: psoriasis AND (ixekizumab OR secukinumab OR brodalumab OR risankizumab OR guselkumab OR tildrakizumab). A total of 27 studies were included for data extraction and qualitative synthesis, and 26 of these were quantitatively analysed. The shortest time to 25% and 50% of patients to achieved PASI90 were seen with brodalumab 210 mg every 2 weeks (Q2W; 3.5 weeks and 6.2 weeks, respectively) followed by ixekizumab 80 mg Q2W (4.1 and 7.4 weeks, respectively) and ixekizumab 80 mg Q4W (4.6 and 8.1 weeks, respectively) dosages. In conclusion, clinical trials yielded shorter time to onset of action in studies assessing approved dosing ranges of IL-17 inhibitors compared with studies assessing IL-23 inhibitors.

AB - Several novel biologics are available or in development for moderate-to-severe plaque psoriasis. These drugs may differ in time until Psoriasis Area and Severity Index (PASI) response is obtained. In this systematic review, we examined the time to onset of action for interleukin (IL)-17 and IL-23 agents in the treatment of psoriasis. The primary objective was the weighted mean time needed for 25% and 50% of patients with psoriasis to achieve PASI90. The medical databases PubMed, Web of Science and EMBASE were searched using the following terms: psoriasis AND (ixekizumab OR secukinumab OR brodalumab OR risankizumab OR guselkumab OR tildrakizumab). A total of 27 studies were included for data extraction and qualitative synthesis, and 26 of these were quantitatively analysed. The shortest time to 25% and 50% of patients to achieved PASI90 were seen with brodalumab 210 mg every 2 weeks (Q2W; 3.5 weeks and 6.2 weeks, respectively) followed by ixekizumab 80 mg Q2W (4.1 and 7.4 weeks, respectively) and ixekizumab 80 mg Q4W (4.6 and 8.1 weeks, respectively) dosages. In conclusion, clinical trials yielded shorter time to onset of action in studies assessing approved dosing ranges of IL-17 inhibitors compared with studies assessing IL-23 inhibitors.

U2 - 10.1111/jdv.15920

DO - 10.1111/jdv.15920

M3 - Review

C2 - 31465593

VL - 34

SP - 39

EP - 46

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

SN - 0926-9959

IS - 1

ER -

ID: 250552619