Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug

Research output: Contribution to journalJournal articleResearchpeer-review

8-Epitacrolimus (2), a new l-pipecolic acid macrolide lactone, was obtained by base-catalyzed epimerization of tacrolimus (FK-506, 1), an important immunosuppressive drug, and its structure determined by a single-crystal X-ray diffraction method. The compound was fully characterized by spectroscopic techniques. The epimer is of importance due to its potential biological effects as well as because of its possible formation during formulation, handling, and use of tacrolimus products.
Original languageEnglish
JournalJournal of Natural Products
Issue number4
Pages (from-to)776-779
Publication statusPublished - 18 Feb 2010

ID: 19367332