Survival and failure types after radiation therapy of vulvar cancer
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- 1-s2.0-S2405630817300034-main
Final published version, 619 KB, PDF document
Background and purpose: Describe the survival rates and distribution of events on competing failure types in vulvar carcinoma after treatment with chemoradiation (CRT) or radiation (RT) alone.
Material and methods: We included patients with vulvar carcinoma treated with CRT or RT between 2009 and 2014. Survival was estimated using the Kaplan-Meier method. We performed a competing risk analysis and included five competing events: loco-regional failure (LRF), distant metastasis, LRF plus distant metastasis, and death without evidence of disease, with the remaining patients denoted alive without evidence of disease.
Results: 87 patients were treated. Progression free survival (PFS) and overall survival (OS) at 3 years were 40% and 57%, respectively. 41.3% of patients relapsed, most often loco-regionally. We saw significantly worse PFS and OS for patients older than 68 (p = 0.011/p = 0.010) and for patients treated with definitive RT (p = 0.004/p = 0.005). Competing risk analysis showed increased risk of LRF, and that death was most often related to vulvar cancer. Death without disease recurrence was less frequent, even in the elderly.
Conclusions: LRF was the most common event. PFS and OS were inferior for elderly patients and patients treated definitively. A better understanding of these differences may be used to define risk adapted treatment strategies.
Original language | English |
---|---|
Journal | Clinical and Translational Radiation Oncology |
Volume | 5 |
Pages (from-to) | 20-27 |
ISSN | 2405-6308 |
DOIs | |
Publication status | Published - 2017 |
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 195963155