Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes
Research output: Contribution to journal › Journal article › Research › peer-review
Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.
| Original language | English |
|---|---|
| Journal | European Journal of Endocrinology |
| Volume | 163 |
| Issue number | 1 |
| Pages (from-to) | 81-7 |
| Number of pages | 7 |
| ISSN | 0804-4643 |
| DOIs | |
| Publication status | Published - 1 Jul 2010 |
- Adult, Body Mass Index, Case-Control Studies, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Genotype, Haplotypes, Humans, Male, Middle Aged, Nuclear Proteins, Obesity, Waist Circumference
Research areas
ID: 33502175