Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity
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Structure of the house dust mite allergen Der f 2 : implications for function and molecular basis of IgE cross-reactivity. / Johannessen, Birthe R; Skov, Lars; Kastrup, Jette S; Kristensen, Ole; Bolwig, Caroline; Larsen, Jørgen; Spangfort, Michael; Lund, Kaare; Gajhede, Michael.
In: F E B S Letters, Vol. 579, No. 5, 2005, p. 1208-12.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Structure of the house dust mite allergen Der f 2
T2 - implications for function and molecular basis of IgE cross-reactivity
AU - Johannessen, Birthe R
AU - Skov, Lars
AU - Kastrup, Jette S
AU - Kristensen, Ole
AU - Bolwig, Caroline
AU - Larsen, Jørgen
AU - Spangfort, Michael
AU - Lund, Kaare
AU - Gajhede, Michael
PY - 2005
Y1 - 2005
N2 - The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.
AB - The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.
KW - Allergens
KW - Animals
KW - Antigens, Dermatophagoides
KW - Arthropod Proteins
KW - Cross Reactions
KW - Crystallography, X-Ray
KW - Epitopes
KW - Hydrophobic and Hydrophilic Interactions
KW - Immunoglobulin E
KW - Lipid Metabolism
KW - Models, Molecular
KW - Protein Structure, Tertiary
KW - Pyroglyphidae
U2 - 10.1016/j.febslet.2004.11.115
DO - 10.1016/j.febslet.2004.11.115
M3 - Journal article
C2 - 15710415
VL - 579
SP - 1208
EP - 1212
JO - F E B S Letters
JF - F E B S Letters
SN - 0014-5793
IS - 5
ER -
ID: 40318547