Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity

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Structure of the house dust mite allergen Der f 2 : implications for function and molecular basis of IgE cross-reactivity. / Johannessen, Birthe R; Skov, Lars; Kastrup, Jette S; Kristensen, Ole; Bolwig, Caroline; Larsen, Jørgen; Spangfort, Michael; Lund, Kaare; Gajhede, Michael.

In: F E B S Letters, Vol. 579, No. 5, 2005, p. 1208-12.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Johannessen, BR, Skov, L, Kastrup, JS, Kristensen, O, Bolwig, C, Larsen, J, Spangfort, M, Lund, K & Gajhede, M 2005, 'Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity', F E B S Letters, vol. 579, no. 5, pp. 1208-12. https://doi.org/10.1016/j.febslet.2004.11.115

APA

Johannessen, B. R., Skov, L., Kastrup, J. S., Kristensen, O., Bolwig, C., Larsen, J., ... Gajhede, M. (2005). Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity. F E B S Letters, 579(5), 1208-12. https://doi.org/10.1016/j.febslet.2004.11.115

Vancouver

Johannessen BR, Skov L, Kastrup JS, Kristensen O, Bolwig C, Larsen J et al. Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity. F E B S Letters. 2005;579(5):1208-12. https://doi.org/10.1016/j.febslet.2004.11.115

Author

Johannessen, Birthe R ; Skov, Lars ; Kastrup, Jette S ; Kristensen, Ole ; Bolwig, Caroline ; Larsen, Jørgen ; Spangfort, Michael ; Lund, Kaare ; Gajhede, Michael. / Structure of the house dust mite allergen Der f 2 : implications for function and molecular basis of IgE cross-reactivity. In: F E B S Letters. 2005 ; Vol. 579, No. 5. pp. 1208-12.

Bibtex

@article{544cc5e6b187404fb96e020027511cd0,
title = "Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity",
abstract = "The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.",
keywords = "Allergens, Animals, Antigens, Dermatophagoides, Arthropod Proteins, Cross Reactions, Crystallography, X-Ray, Epitopes, Hydrophobic and Hydrophilic Interactions, Immunoglobulin E, Lipid Metabolism, Models, Molecular, Protein Structure, Tertiary, Pyroglyphidae",
author = "Johannessen, {Birthe R} and Lars Skov and Kastrup, {Jette S} and Ole Kristensen and Caroline Bolwig and J{\o}rgen Larsen and Michael Spangfort and Kaare Lund and Michael Gajhede",
year = "2005",
doi = "10.1016/j.febslet.2004.11.115",
language = "English",
volume = "579",
pages = "1208--12",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Structure of the house dust mite allergen Der f 2

T2 - implications for function and molecular basis of IgE cross-reactivity

AU - Johannessen, Birthe R

AU - Skov, Lars

AU - Kastrup, Jette S

AU - Kristensen, Ole

AU - Bolwig, Caroline

AU - Larsen, Jørgen

AU - Spangfort, Michael

AU - Lund, Kaare

AU - Gajhede, Michael

PY - 2005

Y1 - 2005

N2 - The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.

AB - The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.

KW - Allergens

KW - Animals

KW - Antigens, Dermatophagoides

KW - Arthropod Proteins

KW - Cross Reactions

KW - Crystallography, X-Ray

KW - Epitopes

KW - Hydrophobic and Hydrophilic Interactions

KW - Immunoglobulin E

KW - Lipid Metabolism

KW - Models, Molecular

KW - Protein Structure, Tertiary

KW - Pyroglyphidae

U2 - 10.1016/j.febslet.2004.11.115

DO - 10.1016/j.febslet.2004.11.115

M3 - Journal article

C2 - 15710415

VL - 579

SP - 1208

EP - 1212

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 5

ER -

ID: 40318547