Structural basis of cell-cell adhesion by NCAM
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Structural basis of cell-cell adhesion by NCAM. / Kasper, C; Rasmussen, H; Kastrup, Jette Sandholm Jensen; Ikemizu, S; Jones, E Y; Berezin, V; Bock, E; Larsen, I K.
In: Nature Structural and Molecular Biology, Vol. 7, No. 5, 2000, p. 389-393.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Structural basis of cell-cell adhesion by NCAM
AU - Kasper, C
AU - Rasmussen, H
AU - Kastrup, Jette Sandholm Jensen
AU - Ikemizu, S
AU - Jones, E Y
AU - Berezin, V
AU - Bock, E
AU - Larsen, I K
PY - 2000
Y1 - 2000
N2 - The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.
AB - The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.
KW - Amino Acid Sequence
KW - Animals
KW - Binding Sites
KW - Calcium
KW - Cell Adhesion
KW - Crystallography, X-Ray
KW - Dimerization
KW - Heparin
KW - Hydrogen Bonding
KW - Immunoglobulins
KW - Models, Molecular
KW - Molecular Sequence Data
KW - Neural Cell Adhesion Molecules
KW - Protein Binding
KW - Protein Structure, Secondary
KW - Protein Structure, Tertiary
KW - Rats
KW - Sequence Alignment
KW - Structure-Activity Relationship
U2 - 10.1038/75165
DO - 10.1038/75165
M3 - Journal article
C2 - 10802736
VL - 7
SP - 389
EP - 393
JO - Nature Structural and Molecular Biology
JF - Nature Structural and Molecular Biology
SN - 1545-9993
IS - 5
ER -
ID: 177814