Stem villous arteries from the placentas of heavy smokers: functional and mechanical properties.

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Stem villous arteries from the placentas of heavy smokers: functional and mechanical properties. / Clausen, Helle Vibeke; Jorgensen, J C; Ottesen, B.

In: American Journal of Obstetrics and Gynecology, Vol. 180, No. 2 Pt 1, 1999, p. 476-482.

Research output: Contribution to journal › Journal article › Research

Harvard

Clausen, HV, Jorgensen, JC & Ottesen, B 1999, 'Stem villous arteries from the placentas of heavy smokers: functional and mechanical properties.', American Journal of Obstetrics and Gynecology, vol. 180, no. 2 Pt 1, pp. 476-482. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9988822&query_hl=183>

APA

Clausen, H. V., Jorgensen, J. C., & Ottesen, B. (1999). Stem villous arteries from the placentas of heavy smokers: functional and mechanical properties. American Journal of Obstetrics and Gynecology, 180(2 Pt 1), 476-482. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9988822&query_hl=183

Vancouver

Clausen HV, Jorgensen JC, Ottesen B. Stem villous arteries from the placentas of heavy smokers: functional and mechanical properties. American Journal of Obstetrics and Gynecology. 1999;180(2 Pt 1):476-482.

Author

Clausen, Helle Vibeke ; Jorgensen, J C ; Ottesen, B. / Stem villous arteries from the placentas of heavy smokers: functional and mechanical properties. In: American Journal of Obstetrics and Gynecology. 1999 ; Vol. 180, No. 2 Pt 1. pp. 476-482.

Bibtex

@article{6e8b3a5171c548bab78877018d249522,

title = "Stem villous arteries from the placentas of heavy smokers: functional and mechanical properties.",

abstract = "OBJECTIVE: The aim of the study was to compare the mechanical and functional properties of isolated small stem villous arteries from the placentas of women who smoked heavily (>/=15 cigarettes/d) during pregnancy with those from the placentas of nonsmokers. STUDY DESIGN: Isolated stem villous arteries were mounted in small-vessel myographs. Circumference-tension relationships were established with 124 mmol/L potassium chloride. Concentration-response curves were obtained for endothelin 1, prostaglandin F2alpha, vasoactive intestinal peptide, corticotropin-releasing hormone, sodium nitroprusside, and cadmium chloride. The effect of nitric oxide was examined with N omega-nitro-l -arginine. RESULTS: Stem villous arteries from the heavy smoking group developed a significantly lower tension than did those from nonsmokers at 6 of 9 steps of the circumference-tension experiment (P <.05). Endothelin 1 evoked a significantly greater maximum vasoconstrictive response in stem villous arteries from heavy smokers than in those from nonsmokers (P <.05). CONCLUSION: Stem villous arteries of heavy smokers have altered mechanical properties and a greater vasoconstrictive response to endothelin 1 than do those from nonsmokers. These changes may compromise fetal placental blood flow and thereby contribute to the lower birth weights seen among infants born to heavy smokers.",

author = "Clausen, {Helle Vibeke} and Jorgensen, {J C} and B Ottesen",

year = "1999",

language = "English",

volume = "180",

pages = "476--482",

journal = "American Journal of Obstetrics & Gynecology",

issn = "0002-9378",

publisher = "Mosby Inc.",

number = "2 Pt 1",

}

RIS

TY - JOUR

T1 - Stem villous arteries from the placentas of heavy smokers: functional and mechanical properties.

AU - Clausen, Helle Vibeke

AU - Jorgensen, J C

AU - Ottesen, B

PY - 1999

Y1 - 1999

N2 - OBJECTIVE: The aim of the study was to compare the mechanical and functional properties of isolated small stem villous arteries from the placentas of women who smoked heavily (>/=15 cigarettes/d) during pregnancy with those from the placentas of nonsmokers. STUDY DESIGN: Isolated stem villous arteries were mounted in small-vessel myographs. Circumference-tension relationships were established with 124 mmol/L potassium chloride. Concentration-response curves were obtained for endothelin 1, prostaglandin F2alpha, vasoactive intestinal peptide, corticotropin-releasing hormone, sodium nitroprusside, and cadmium chloride. The effect of nitric oxide was examined with N omega-nitro-l -arginine. RESULTS: Stem villous arteries from the heavy smoking group developed a significantly lower tension than did those from nonsmokers at 6 of 9 steps of the circumference-tension experiment (P <.05). Endothelin 1 evoked a significantly greater maximum vasoconstrictive response in stem villous arteries from heavy smokers than in those from nonsmokers (P <.05). CONCLUSION: Stem villous arteries of heavy smokers have altered mechanical properties and a greater vasoconstrictive response to endothelin 1 than do those from nonsmokers. These changes may compromise fetal placental blood flow and thereby contribute to the lower birth weights seen among infants born to heavy smokers.

AB - OBJECTIVE: The aim of the study was to compare the mechanical and functional properties of isolated small stem villous arteries from the placentas of women who smoked heavily (>/=15 cigarettes/d) during pregnancy with those from the placentas of nonsmokers. STUDY DESIGN: Isolated stem villous arteries were mounted in small-vessel myographs. Circumference-tension relationships were established with 124 mmol/L potassium chloride. Concentration-response curves were obtained for endothelin 1, prostaglandin F2alpha, vasoactive intestinal peptide, corticotropin-releasing hormone, sodium nitroprusside, and cadmium chloride. The effect of nitric oxide was examined with N omega-nitro-l -arginine. RESULTS: Stem villous arteries from the heavy smoking group developed a significantly lower tension than did those from nonsmokers at 6 of 9 steps of the circumference-tension experiment (P <.05). Endothelin 1 evoked a significantly greater maximum vasoconstrictive response in stem villous arteries from heavy smokers than in those from nonsmokers (P <.05). CONCLUSION: Stem villous arteries of heavy smokers have altered mechanical properties and a greater vasoconstrictive response to endothelin 1 than do those from nonsmokers. These changes may compromise fetal placental blood flow and thereby contribute to the lower birth weights seen among infants born to heavy smokers.

M3 - Journal article

VL - 180

SP - 476

EP - 482

JO - American Journal of Obstetrics & Gynecology

JF - American Journal of Obstetrics & Gynecology

SN - 0002-9378

IS - 2 Pt 1

ER -

ID: 40147131